A5049227517- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Hypothalamic control of reproductive hormones
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Estrogen and related hormone effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Point processes and geometric inequalities
- Nerve injury and regeneration
- Ovarian function and disorders
- Sports injuries and prevention
- Fatty Acid Research and Health
- Neuroscience of respiration and sleep
Centre for Health Technology and Services Research
2016-2025
Universidade do Porto
2016-2025
Hospital de São João
1988-1994
Thyroid hormone deficiency has long been considered to affect profoundly such cognitive functions as learning and memory, which are known depend on the structural integrity of hippocampal formation. Since we previously found that number granule cells dentate gyrus is reduced in hypothyroid animals, decided extend our observations pyramidal hippocampus order gain further insight into effects hypothyroidism upon other neuronal links trisynaptic circuitry, inasmuch CA1 neurons be particularly...
Abstract The circadian rhythms displayed by numerous biological functions are known to be sex specific and affected aging. It has not been settled yet whether the sex‐ age‐related characteristics of derive from changes in anatomy suprachiasmatic nucleus. To shed light on these issues, we applied unbiased stereological techniques estimate volume nucleus as well total number its cells mean their somata nuclei progressively older groups male female Wistar rats (aged 1, 6, 12, 18, 24, 30...
There is evidence that chronic ethanol treatment (CET) disrupts the biological rhythms of various brain functions and behaviors. Because suprachiasmatic nucleus (SCN) widely recognized as dominant pacemaker circadian system, we have examined effects CET withdrawal on main morphological features chemoarchitecture this hypothalamic nucleus. Groups rats ethanol-treated for 6 12 months were compared with withdrawn (ethanol-treated then switched to a normal diet an additional months) groups...
Abstract The effects of hypothyroidism upon the structure central nervous system adult rats are poorly understood in spite evidence that mature brain is vulnerable to this condition. Existing developmental studies show morphological changes induced by thyroid hormone deficiency related alterations neurogenesis. We studied granular layer dentate gyrus under different experimental conditions hypothyroidism, because rodents neurogenesis granule cells continues during adulthood. following groups...
Exposure of rats to sustained stress has been associated with behavioural impairments, the degree impairment being greater increasing age subject. Although deficits have frequently attributed stress-induced neuronal loss in hippocampus, validity that view may be disputed since it is based on data collected using conventional morphometric methods which are subject bias. The question whether per se does indeed induce hippocampal cell losses was therefore re-examined unbiased stereological...
High-caloric diets induce several deleterious alterations in the human body, including brain. However, information on effects of these elderly brain is scarce. Therefore, we studied 2 months treatment with high-fat (HF) and high-fat-high-sugar (HFHS) aged male Wistar rats at 18 months. Anxiety levels were analyzed using open-field plus-maze tests, while learning memory processes Morris water maze test. We also neurogenesis doublecortin (DCX) neuroinflammation glial fibrillary acidic protein...
Differences in lumbar morphology and nerve root positioning between supine prone decubitus are poorly analyzed. This study aimed to perform a magnetic resonance imaging (MRI) describe morphology, root, related structures the position, while comparing with conventional MRI, patients symptoms. The second aim was define safe working zones for surgical procedures. prospective, single-center, observational study. Fifty persistent low back and/or radicular pain that unresponsive conservative...
Neurons in the ventromedial nucleus of hypothalamus (VMN) display structural and biochemical sex differences response to estrogen. Despite this fact, reports on morphology VMN are restricted its volume synaptic patterning. The aim study was characterize neuroanatomical sexual dimorphisms investigate whether endogenous changes ovarian steroid secretion influence such dimorphisms. adult male rats intact, aged-matched female killed proestrus diestrus day 1 examined by using stereological...
Abstract The effects of long‐term alcohol consumption and withdrawal upon the structure rat hippocampal formation were studied by applying morphometric methods to material processed for light electron microscopy. somatostatinergic neurons hilus zvere aha studied. Groups 6 rats treated as follows: (a) given 6, 12 18 months; (b) paired controls; (c) switched a normal diet in months after month!, intake. A progressive loss chronic was found. aggravated during from alcohol, with exception hilar...
Abstract Thyroid hormone deficiency has been reported to interfere with synaptogenesis, particularly in those regions of the brain where neurons display a late and protracted histogenesis, although extent synaptic alterations remains unknown. To provide detailed quantitative data on effects hypothyroidism upon synapses, link hippocampal circuitry was selected: contact between mossy fibers dendritic excrescences CA3 pyramidal cells (MF‐CA3 synapses). Groups six male female rats aged 30 180...
The arcuate nucleus of the hypothalamus (ARN) is involved in a variety functions known to be sexually dimorphic and altered by aging. Although effects sex age on synaptic organization neurochemistry ARN have been extensively analyzed, data regarding sex-related differences age-induced total number neurons volume adult aged male female rats are controversial. To address this issue, we quantitatively analyzed Wistar 6 24 months. optical fractionator, rotator, Principle Cavalieri were used as...