A5052262788- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Nanoparticle-Based Drug Delivery
- Molecular Sensors and Ion Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fish Ecology and Management Studies
- Analytical Chemistry and Chromatography
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Nanoplatforms for cancer theranostics
- Synthetic Organic Chemistry Methods
- Supramolecular Chemistry and Complexes
- Molecular Junctions and Nanostructures
- Electrochemical Analysis and Applications
- Supramolecular Self-Assembly in Materials
- Surfactants and Colloidal Systems
- Lysosomal Storage Disorders Research
- Protein Structure and Dynamics
- Connective tissue disorders research
- Photochemistry and Electron Transfer Studies
- Sphingolipid Metabolism and Signaling
Purdue University West Lafayette
2016-2025
Purdue University Institute for Cancer Research
2005-2024
State Street (United States)
2015-2022
Center for Cancer Research
2011-2022
Indiana University School of Medicine
2019
Indiana University
2019
University School
2019
Georgia Institute of Technology
2018
Centre for Multi-disciplinary Development Research
2018
University of Louisiana at Lafayette
2018
Many organisms construct structural ceramic (biomineral) composites from seemingly mundane materials; cell-mediated processes control both the nucleation and growth of mineral development composite microarchitecture. Living systems fabricate biocomposites by: (i) confining biomineralization within specific subunit compartments; (ii) producing a with defined crystal size orientation; (iii) packaging many incremental units together in moving front process to form fully densified, macroscopic...
This paper reports the creation of Au nanoparticles (AuNP) that are soluble in aqueous solution over a broad range pH and ionic strength values capable selective uptake by folate receptor positive (FR+) cancer cells. A novel poly(ethylene glycol) (PEG) construct with thioctic acid folic coupled on opposite ends polymer chain was synthesized for targeting AuNP to FR+ tumor cells via receptor-mediated endocytosis. These acid−PEG−thioctic conjugates were grafted onto 10-nm-diameter particles...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThermally and Photochemically Triggered Self-Assembly of Peptide HydrogelsJoel H. Collier, Bi−Huang Hu, Jeffrey W. Ruberti, Jerry Zhang, Pochi Shum, David Thompson, Phillip B. MessersmithView Author Information Northwestern University Biomedical Engineering Department 2145 Sheridan Road, Evanston, Illinois 60208 Purdue Chemistry, Brown Laboratory West Lafayette, Indiana 47907 Cite this: J. Am. Chem. Soc. 2001, 123, 38, 9463–9464Publication...
Abstract Arsenic trioxide (As2O3) is a frontline drug for treatment of acute promyelocytic leukemia and in clinical trials other malignancies, including multiple myeloma; however, efforts to expand utility solid tumors have been limited by toxicity. Nanoparticulate forms As2O3 encapsulated 100-nm-scale, folate-targeted liposomes developed lower systematic toxicity provide platform targeting this agent. The resultant arsenic “nanobins” are stable under physiologic conditions but undergo...
Due to their controllable size, low cytotoxicity, and unique architecture, cyclodextrin‐based polyrotaxanes pseudopolyrotaxanes have been developed encompass a broad range of diverse medical applications from erodable hydrogels drug gene delivery. This review summarizes the synthesis, characterization, dynamics, applications, potential utility cyclodextrin based for applications. Specifically, this article reviews literature appearing on topic between 1999 November 2006.
We report the high throughput analysis of reaction mixture arrays using methods and data handling routines that were originally developed for biological tissue imaging.
A self-assembled nanogel, derived from an acid-labile cholesteryl-modified pullulan (acL-CHP), was prepared by grafting vinyl ether-cholesterol substituents onto a 100 kD main chain polymer backbone. Stable nanogels are formed acL-CHP self-assemblies at neutral pH. The hydrodynamic radius of the nanogels, observed to be 26.5 ± 5.1 nm pH 7.0, increased ~135% upon acidification solution 4.0. SEC analysis nanogel 4.0 showed that grafts were nearly 80% degraded after 24 h, whereas little or no...
Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that depend on the tissue analyzed. Retinal lipofuscin is unique it contains mostly with very little proteins. However, retinal also presents biological physicochemical characteristics indistinguishable from conventional granules, including indigestibility, tendency to cause lysosome swelling results rupture or defective functions, ability trigger NLRP3 inflammation, a symptom low-level disruption...
Most pharmaceutical and gene therapy applications of targeted liposomes presently suffer from inefficient contents delivery to the cytoplasm target cells. We report a plasma-stable liposome, composed synthetic, naturally occurring diplasmenylcholine (1,2-di-O-(Z-1'-hexadecenyl)-sn-glycero-3-phosphocholine; DPPlsC), that rapidly efficiently releases its at endosomal pHs. Acid-catalyzed hydrolysis these produces glycerophosphocholine fatty aldehydes, leading greatly enhanced liposome...
The unique symmetry properties of second harmonic generation (SHG) microscopy enabled sensitive and selective imaging protein microcrystals with negligible contributions from solvated proteins or amorphous aggregates. In studies microcrystallites green fluorescent (GFP) prepared in 500 pL droplets, the SHG intensities rivaled those fluorescence, but superb selectivity for crystalline regions. GFP aggregates solution produced substantial background no detectable SHG. ratio forward-to-backward...
ABRIDGED: We study the evolution since z~1 of rest-frame B luminosity function early-type galaxies (ETGs) in ~0.7 deg^2 COSMOS field. In order to identify ALL progenitors local ETGs we construct sample high-z using two complementary criteria: (i) A morphological selection based on Zurich Estimator Structural Types, and (ii) photometric galaxy properties (U-V)-M_V color-magnitude diagram. furthermore constrain both samples so as ensure that selected are compatible with evolving into systems...
A novel siRNA delivery vector has been developed, based on the self-assembly of monosubstituted cationic β-CD derivatives with a poly(vinyl alcohol)MW27kD (PVA) main-chain polymer bearing poly(ethylene glycol)MW2000 (PEG) and acid-labile cholesterol-modified (Chol) grafts through an acid-sensitive benzylidene acetal linkage. These components were investigated for their ability to form nanoparticles using two different assembly schemes, involving either precomplexation pendant Chol-PVA-PEG...
Abstract Photodynamic therapy (PDT) is a promising cancer treatment modality that can selectively target unresectable tumors through optical activation of cytotoxic agents, thus reducing many side effects associated with systemic administration chemotherapeutic drugs. However, limited light penetration into most biological tissues have so far prevented its widespread adoption beyond dermatology and few other oncological applications in which fiber optic be threaded to the desired locations...
Some valuable determinations of dissolved oxygen in the channel were made by State Water Survey on January 23 and 24 February 6 7, 1925, which are published here for first time.
Thirty-four aspirates of pus from peritonsillar abscesses that were studied for aerobic and anaerobic bacteria showed bacterial growth. A total 107 isolates (58 49 facultative) recovered, accounting 3.1 per specimen (1.7 1.4 facultatives). Anaerobic only present in 6 (18%) patients, facultatives 2 (6%), mixed flora 26 (76%). Single recovered 4 infections, which Streptococcus pyogenes bacteria. The predominant Staphylococcus aureus (6 isolates), Bacteroides sp (21 isolates, including 15...
A polypseudorotaxane consisting of cucurbit[7]uril (CB[7])/N,N'-(3-phenylenebis(methylene)dipropargylamine (PMPA), [2]pseudorotaxane, and 2,6-O-dimethyl β-cyclodextrin (DM-β-CD)/α,ω-bisazidopropylene glycol 400 [2]pseudorotaxane was synthesized using the "click" reaction. The structure maintained in aqueous solution over a wide range pH values with DM-β-CD units contributing to increased solubilization without dethreading. pH-responsive movement CB[7] also observed.