A5003094782- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Medicinal Plant Extracts Effects
- Medicinal Plants and Neuroprotection
- Synthesis and Biological Evaluation
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2023
Universidade Federal do Rio de Janeiro
2017-2023
In general, Passiflora species have been reported for their folk medicinal use as sedative and anti-inflammatory. However, P. caerulea has already to treat pulmonary diseases. Severe tuberculosis, generally caused by Mycobacterium tuberculosis strains resistant multiple drugs, can lead deleterious inflammation high mortality, encouraging new approaches in drug discovery. Thus, the aim of this work was evaluate mucronata Lam., Passifloraceae, potential treatment. Specifically, related...
Abstract Leishmaniasis is an emerging tropical infectious disease caused by a protozoan parasite of the genus Leishmania . In this work, molecular hybridization between trimethoxy chalcone and sulfonamide group was used to generate series sulfonamide‐chalcones. A eight sulfonamide‐chalcone hybrids were made with good yields (up 95%). These sulfonamide‐chalcones tested against promastigotes amazonensis cytotoxicity mouse macrophages, which showed antileishmanial activity IC 50 = 1.72–3.19 µM....