A5089728847- Protein Structure and Dynamics
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Enzyme Structure and Function
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mass Spectrometry Techniques and Applications
- NMR spectroscopy and applications
- Immune cells in cancer
- Bacillus and Francisella bacterial research
- Cancer Immunotherapy and Biomarkers
- Advanced NMR Techniques and Applications
- CAR-T cell therapy research
- Biochemical and Molecular Research
Harvard University
2023-2024
Dana-Farber Cancer Institute
2023-2024
Boston VA Research Institute
2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2021-2022
Université Grenoble Alpes
2021-2022
Institut de Biologie Structurale
2020-2022
CEA Grenoble
2021-2022
Centre National de la Recherche Scientifique
2021-2022
Jagiellonian University
2017
Blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer treatment. The antibody-based immunotherapies carry a number disadvantages such as high cost antibodies, their limited half-life, and immunogenicity. Development small-molecule inhibitors that could overcome these drawbacks is slow because incomplete structural information for this pathway. first chemical have been recently disclosed by Bristol-Myers Squibb. Here we...
Abstract Transcriptional condensates play a crucial role in gene expression and regulation, yet their assembly mechanisms remain poorly understood. Here, we report multi-layered mechanism for condensate by autoimmune regulator (Aire), an essential transcriptional that orchestrates reprogramming central T cell tolerance. Aire assemble on enhancers, stimulating local activities connecting disparate inter-chromosomal loci. This functional formation hinges upon the coordination between three...
Abstract Chaperones, as modulators of protein conformational states, are key cellular actors to prevent the accumulation fibrillar aggregates. Here, we integrated kinetic investigations with structural studies elucidate how ubiquitous co-chaperonin prefoldin inhibits diabetes associated islet amyloid polypeptide (IAPP) fibril formation. We demonstrated that both human and archaeal interfere similarly IAPP elongation secondary nucleation pathways. Using model, combined nuclear magnetic...
Tryptophan plays a critical role in proteins by contributing to stability, allostery, and catalysis. Using fluorine (
Abstract Transcriptional condensates play a crucial role in gene expression and regulation 1–4 , yet the mechanisms governing their assembly at correct location time remain poorly understood 2,5–7 . We here report multi-layered mechanism for condensate by Autoimmune regulator (Aire), an essential transcriptional (TR) that orchestrates reprogramming central T-cell tolerance 8,9 Previous studies demonstrated Aire utilizes its polymerizing domain CARD to form nuclear critical activity 10,11 Our...
Abstract Chaperones, as modulators of protein conformational states, are key cellular actors to prevent the accumulation fibrillar aggregates. Here, we integrated kinetic investigations with structural studies elucidate how ubiquitous co-chaperonin prefoldin (PFD) inhibits diabetes associated islet amyloid polypeptide (IAPP) fibril formation. We demonstrated that both human and archaeal PFD interfere similarly IAPP elongation secondary nucleation pathways. Using model, combined NMR...