A5041737648- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Grief, Bereavement, and Mental Health
- Family Support in Illness
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Interprofessional Education and Collaboration
- LGBTQ Health, Identity, and Policy
- Cytokine Signaling Pathways and Interactions
- Childhood Cancer Survivors' Quality of Life
- Chemical Synthesis and Analysis
- Aging and Gerontology Research
- Intergenerational Family Dynamics and Caregiving
- Cancer survivorship and care
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Patient Dignity and Privacy
- Healthcare cost, quality, practices
- Mentoring and Academic Development
- Social Policy and Reform Studies
- Health and Well-being Studies
- Health, psychology, and well-being
- Synthesis and Biological Evaluation
Hunter College
2015-2023
City University of New York
2015-2023
Bristol-Myers Squibb (United States)
2002-2021
Bellevue Hospital Center
2017
New York State University College of Human Ecology
2016
Children's Aid Society
2016
National Business Group on Health
2016
Keck Hospital of USC
2016
University of North Carolina at Chapel Hill
2016
Cornell University
2016
Despite the advances and spread of palliative care programs, communities color remain significantly underserved. Although these disparities are widely known, there is a marked lack empirical evidence. The authors conducted systematic scoping review that synthesized literature since 2000 about racial ethnic in end-of-life care. We searched PubMed, Medline, SocIndex, CINAHL, Social Work Abstracts, PsycINFO, using search terms including or care, barriers utilization, race ethnicity African...
This study examined the end-of-life challenges, concerns, and care preferences of terminally ill elders their family caregivers, with a focus on areas congruence incongruence. Ten 10 caregivers participated in separate, semi-structured, face-to-face interviews. Data analysis included team coding thematic analysis, guided by an priori set categories based questions. Shared challenges concerns experiencing decline, managing pain discomfort, living uncertainty. There was also regarding...
High-affinity, functionally potent, urea-based antagonists of CCR1 have been discovered. Modulation PXR transactivation has revealed the selective and orally bioavailable antagonist BMS-817399 (29), which entered clinical trials for treatment rheumatoid arthritis.
As a member of the Janus (JAK) family non-receptor tyrosine kinases, TYK2 mediates signaling pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN), therefore represents an attractive potential target for treating various immuno-inflammatory diseases in which these have been shown to play role. Following up on our previous report that ligands pseudokinase domain (JH2) suppress cytokine-mediated receptor activation catalytic (JH1) domain, imidazo[1,2-
Concern over the need for effective and accessible healthcare individuals with advanced chronic illness has drawn attention to significant gaps in our knowledge of palliative medicine. To advance understanding this field, community-based participatory research (CBPR) is proposed as a tool future initiatives. This paper offers rationale how CBPR may be employed address specific care research. Several examples where approach been used previously are described, potential obstacles implementing...
Starting with our previously described20 class of CC chemokine receptor-3 (CCR3) antagonist, we improved the potency by replacing phenyl linker 1 a cyclohexyl and 4-benzylpiperidine 3-benzylpiperidine. The resulting compound, 32, is potent selective antagonist CCR3. SAR studies showed that 3-acetylphenyl urea 32 could be replaced heterocyclic ureas or heterocyclic-substituted still maintain (inhibition eotaxin-induced chemotaxis) this compounds in low-picomolar range (IC50 = 10−60 pM),...
A growing number of older adults are finding that retirement is no longer affordable and they must work well into their later years. Unfortunately, over 42 years after passage the Age Discrimination in Employment Act (ADEA) 1967, age discrimination workplace continues to present serious impediments employment life. Using a critical gerontology perspective, this paper reviews history work-related analyzes ADEA its limited effectiveness at protecting civil economic rights workers. The authors...
Dramatic changes in demography, epidemiology, and the financing delivery of health care have significantly affected lives older adults their families. The authors review current future trends aging United States implications for social work practice enhancing well-being caregivers. Health 21st century requires development application evidence-based knowledge that reflects interrelatedness aging, physical mental health, intergenerational family processes. demonstrate value research to issues...
ABSTRACT Ambiguity in the dying experience can be a major source of stress for older couples who must often balance provision care with respect autonomy, aggressive treatment quality-of-life, and individual dyadic understandings preferences. This study explores patterns relationship, support, communication married or partnered where one partner is diagnosed advanced terminal cancer. Thirty-five spousal/partner dyads participated focused, semistructured interviews about relational aspects...
Family narratives of genetic disease address multigenerational legacies illness, guide expectations about future diagnoses and anticipated losses, promote continuity coherence. Yet contemporary families with histories face the challenge integrating long-standing family illness technological advances in detection treatment identified disease. The authors recommend use narrative methods to (a) integrate multiple or competing perspectives into a comprehensive story experience, (b) accommodate...
As Americans live longer with chronic illnesses, there is a growing need for social workers the knowledge and skills to deliver quality palliative care older adults their families. Nevertheless, remains critical shortage of prepared provide end-of-life (PELC) maintain field into next generation. Formal mentorship programs represent an innovative approach enhancing practice, providing support guidance, promoting work leadership in field. This article reviews literature on as professional...
Social work practice with older adults and their families is increasingly recognized by the profession as a major field of in wide range health care community-based settings. This article reviews emerging trends issues fields aging care, drawing on gerontological research which bridges these areas. Given growing number diversity our society, dramatic changes organization delivery authors suggest skills competencies essential to enhancing well-being 21st Century.
Purpose: To explore the psychosocial needs of cancer patients and survivors across United States their implications for value-based oncology.Design: A secondary analysis findings from a cross-sectional national online survey.Sample: Respondents were sampled stratified by type geographic region to approximate cancer-affected population States. Breast, prostate, colorectal most common cancers reported. Across surveys, majority respondents female (57%), over 55 (60%), white (70%) had at least...
We encountered a dilemma in the course of studying series antagonists G-protein coupled receptor CC chemokine receptor-2 (CCR2): compounds with polar C3 side chains exhibited good ion channel selectivity but poor oral bioavailability, whereas lipophilic bioavailability preclinical species selectivity. Attempts to solve this through direct modulation physicochemical properties failed. However, installation protonation-dependent conformational switching mechanism resolved problem because it...
Although palliative care (PC) has become increasingly familiar, considerable gaps persist in access to and use of services. Community-based programs remain rare, low-income, minority communities significantly under-utilize hospice We used community-based participatory research (CBPR) methods conduct a mixed-methods community needs assessment seriously-ill older adults (n=100) providers from churches (n=41) an urban medically-underserved the U.S. explore: (I) prevalence severity...
Although social work has a long and distinctive tradition of practice-relevant research aimed at enhancing the health well-being older adults, profession been underrepresented among ranks academic researchers National Institutes Health's (NIH) scientific endeavors. In this article, inherent capacities workers to generate disseminate empirical health-related knowledge are discussed recent developments in work's geriatric infrastructure described. Emerging domains for advancing profession's...