A5016620344- Alzheimer's disease research and treatments
- Retinoids in leukemia and cellular processes
- Methemoglobinemia and Tumor Lysis Syndrome
- Cholinesterase and Neurodegenerative Diseases
- Pomegranate: compositions and health benefits
- Dementia and Cognitive Impairment Research
- Computational Drug Discovery Methods
- Cynara cardunculus studies
- Cell Adhesion Molecules Research
- Retinal Development and Disorders
- Phytase and its Applications
- Neonatal Health and Biochemistry
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nerve injury and regeneration
- Silk-based biomaterials and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Hedgehog Signaling Pathway Studies
- Tryptophan and brain disorders
- Electrospun Nanofibers in Biomedical Applications
- interferon and immune responses
- Protein Structure and Dynamics
University of Aberdeen
2020-2024
University of Leeds
2018
University of St Andrews
2012-2016
Queen Mary University of London
2011
Institute of Medical Sciences
2011
Abstract The use of biomarker-led clinical trial designs has been transformative for investigating amyloid-targeting therapies Alzheimer’s disease (AD). have ensured the correct selection patients on these trials, supported target engagement and used to support claims modification efficacy. Ultimately, this recently led approval disease-modifying, AD; something that should be noted trials tau-targeting AD. There is a clear overlap purpose biomarker at each stage development between trials....
Primary cilia are solitary organelles that emanate from the plasma membrane during growth arrest in almost all mammalian cells. The canonical Hedgehog (HH) pathway requires trafficking of G protein-coupled receptor SMOOTHENED (SMO) and GLI transcription factors to primary cilium upon binding a HH ligand PATCHED1. However, it is unknown if activation small GTPase RHOA by SMO coupling heterotrimeric Gi proteins, form non-canonical signaling, localization cilium. In this study, we compared...
Abstract The tau protein (residues 297-391) forms the core of oligomers and filaments that drive neurodegeneration in Alzheimer’s disease (AD). mechanisms pathological assembly pharmacological inhibition need to be understood before novel treatments can developed. Molecular dynamics modeling, confirmed by immunochemistry, revealed self-assembly involves initial capture via residues 337-355 a conformational switch at proline 332, followed unfolding zipper-like into stable H-bonded structure...
Phospholipase C-η2 is a recently identified phospholipase C (PLC) implicated in the regulation of neuronal differentiation/maturation. PLCη2 activity triggered by intracellular calcium mobilization and likely serves to amplify Ca²⁺ signals stimulating further release from Ins(1,4,5)P₃-sensitive stores. The role neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation. expression increased two-fold 4-day differentiation period. Stable PLCη2-targetted shRNA...
Neurite growth is central to the formation and differentiation of functional neurons, recently, an essential role for phospholipase C-η2 (PLCη2) in neuritogenesis was revealed. Here we investigate function PLCη2 using Neuro2A cells, which upon stimulation with retinoic acid differentiate form neurites. We first investigated calcium-binding EF-hand domain, a domain that known be required activation. To do this, quantified neurite outgrowth stably overexpressing wild-type D256A (EF-hand) H460Q...
Methylthioninium chloride (MTC) is a standard treatment for methaemoglobinaemia. A preparation of reduced MTC has been reported to increase blood oxygen saturation (SpO2) and lower respiratory rates in patients with severe COVID-19. We have developed stable form methylthionine (hydromethylthionine-mesylate, HMTM) having benign safety profile two Phase 3 trials Alzheimer's disease. The aim this prospective study was determine the effects oral HMTM on SpO2 methaemoglobin (metHb) levels cohort...