A5051464594- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Health, Nursing, Elderly Care
- Reproductive System and Pregnancy
- Health disparities and outcomes
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Birth, Development, and Health
- Child Nutrition and Water Access
- Pregnancy and Medication Impact
- Pediatric health and respiratory diseases
- Migration, Aging, and Tourism Studies
- Neuropeptides and Animal Physiology
- Aging, Health, and Disability
- Olfactory and Sensory Function Studies
- Respiratory and Cough-Related Research
- Pancreatic and Hepatic Oncology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dermatology and Skin Diseases
- Protease and Inhibitor Mechanisms
University of Coimbra
2015-2024
ORCID
2019
Institute for Systems Engineering and Computers
2018
Hospitais da Universidade de Coimbra
2005-2016
IPO Porto
2002
Studies using cell lines should always characterize these cells to ensure that the results are not distorted by unexpected morphological or genetic changes possibly due culture time passage number. Thus, aim of this study was describe those MIA PaCa-2 and PANC-1 line phenotype genotype characteristics may play a crucial role in pancreatic cancer therapeutic assays, namely neuroendocrine chemotherapy peptide receptor radionuclide therapy. Epithelial, mesenchymal, endocrine stem marker...
Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which often infiltrated by malignant cells, to progression largely unknown. Thus, this study aimed determine if tissue linked aggressive tumor biology in cancer.Supernatants whole (explants) or stromal vascular fraction (SVF) from paired fat samples (PP) pre-peritoneal visceral (VIS) anatomic origin different donors were prepared analyzed for matrix metalloproteinases...
The aim of this Global Allergy and Asthma European Network (GA(2)LEN) consensus report is to provide recommendations for patient-reported outcomes (PROs) evaluation in clinical trials allergic diseases, which constitute a global health problem terms physical, psychological economic social impact. During the last 40 years, PROs have gained large consideration use scientific community, gain better understanding patients' subjective assessment with respect elements concerning their condition....
To cite this article: Baiardini I, Braido F, Bindslev-Jensen C, Bousquet PJ, Brzoza Z, Canonica GW, Compalati E, Fiocchi A, Fokkens W, Gerth van Wijk R, Giménez-Arnau Godse K, Grattan Grob JJ, La Grutta S, Kalogeromitros D, Kocatürk Lombardi Mota-Pinto Ridolo Saini SS, Sanchez-Borges M, Senna GE, Terreehorst Todo Bom Toubi J, Zuberbier T, Maurer M. Recommendations for assessing patient-reported outcomes and health-related quality of life in patients with urticaria: a GA2LEN taskforce...
The aim of this study is to assess functional capacity and determine the factors associated with decline in elderly adult day care centres home support County Coimbra, Portugal.Cross-sectional study. A total 115 participants both genders, aged between 65 98, were enrolled system Portugal. Functional was assessed using Barthel index Lawton index. Another questionnaire gathered social, demographic health status information.The basic activities daily living significantly age, cohabitation,...
The GA(2)LEN taskforce on Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HRQoL) published in 2009 a position paper concerning PROS HRQoL assessment clinical trials allergy. Because the specificity this topic asthma rhinitis, specific recommendations are needed. aim is to define PROs their meaning rhinitis research, explore available tools provide criteria for proper choice, identify patient-related factor which could influence assessment, analysis results spreading,...
PC3 shows higher ROS production but also the highest GSH levels and Gl‐Red activity, possibly contributing to oxidative stress resistance. This is associated with mitochondrial membrane potential, TAS lower lipid peroxidation. On other hand, we identified activity reduction as a new strategy in overcoming resistance, by inducing H 2 O cytotoxicity. Therefore these results suggest potential therapeutic approach, prostate cancer.
Cite this as: S. Vale‐Pereira, A. Todo‐Bom, L. Geraldes, C. Schmidt‐Weber, Akdis and Mota‐Pinto, Clinical & Experimental Allergy, 2011 (41) 490–496. Summary Background Asthma is a chronic inflammatory disorder in which Th2, Th1 suppressive T cells (Tregs) play role. The transcription factor FoxP3 plays role Treg differentiation while T‐bet important for GATA‐3 Th2 from naïve cells. Recent data show that age‐related deregulation of mechanism senescence affecting several diseases. It...
Objective To provide evidence of the existence membrane progesterone receptor alpha (m PR α ) on regulatory T cells (Treg) in peripheral blood during pregnancy, postulating a possible explanation for effect preterm birth. Design Cross‐sectional study. Setting Tertiary Obstetric Department University Hospital. Population Healthy pregnant women. Methods Treg from samples were studied by flow cytometry using multiple monoclonal antibody expression. Main outcome measures Evaluate number and...
Cross-sectional and longitudinal reports show that obese adults have more asthma than non-obese adults. A proposed mechanism is via effects of adipokines (leptin adiponectin) on the immune system.We wished to measure associations other atopic diseases with serum adipokine levels find whether were strong enough rule out possibility they are secondary association fatness measures asthma.The Global Asthma Allergy Network Excellence (GA(2) LEN) clinical follow-up survey a survey, embedded in...
Asthma and rhinitis have a complex etiology, depending on multiple genetic environmental risk factors. An increasing number of susceptibility genes are currently being identified, but the majority reported associations not been consistently replicated across populations different backgrounds.To evaluate whether polymorphisms IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) GSTP1 (rs1695) associated with and/or asthma in adults Portuguese ancestry.192 unrelated healthy individuals 232...
The prevalence of age-related non-communicable chronic diseases has increased worldwide, being the leading causes morbidity and death in many world regions, including Europe. Innovative models strategies focused on preventive care, early identification risk factors underlying disease onset progression, proper modification lifestyle habits behaviors, might contribute to promote quality life, healthy living active ageing. Healthy Lifestyle Quarters for Cities Citizens (HeaLIQs4cities) is an...
Challenges posed by demographic changes and population aging are key priorities for the Horizon 2020 Program of European Commission. Aligned with vision Innovation Partnership on Active Healthy Ageing (EIP AHA), development, exchange, large-scale adoption innovative good practices is a element responses required to ensure all citizens remain as active healthy possible they age. Urged need developing scalable disruptive innovation across Europe, Commission EIP AHA created Reference Sites;...