A5066631108- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Milk Quality and Mastitis in Dairy Cows
- Ruminant Nutrition and Digestive Physiology
- Animal Behavior and Welfare Studies
- Animal Disease Management and Epidemiology
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Probiotics and Fermented Foods
- Respiratory Support and Mechanisms
- Animal health and immunology
- Vector-Borne Animal Diseases
- Pulmonary Hypertension Research and Treatments
- Brucella: diagnosis, epidemiology, treatment
- Viral gastroenteritis research and epidemiology
- Effects of Environmental Stressors on Livestock
- Infant Nutrition and Health
- Animal Genetics and Reproduction
- Cystic Fibrosis Research Advances
- Bone Tumor Diagnosis and Treatments
- Nursing Diagnosis and Documentation
- Emergency and Acute Care Studies
- Neurofibromatosis and Schwannoma Cases
St George’s University Hospitals NHS Foundation Trust
2025
Massey University
2015-2024
GlaxoSmithKline (United Kingdom)
2016-2024
University of Louisville
2017-2022
GlaxoSmithKline (Germany)
2021
AstraZeneca (Brazil)
2020
Boehringer Ingelheim (Philippines)
2020
Glaxosmithkline (Finland)
2019
GlaxoSmithKline (Netherlands)
2019
Norton Hospital
2018
Cilomilast (Ariflo), a new oral phosphodiesterase-4 selective inhibitor, improves lung function in chronic obstructive pulmonary disease (COPD). We have evaluated its antiinflammatory effects 59 patients with COPD randomized to receive cilomilast, 15 mg two times day, or placebo for 12 weeks. Induced sputum differential cell counts were obtained at baseline and five further visits. Interleukin-8 neutrophil elastase measured supernatant. Bronchial biopsies Week 10 immunostained counted...
To determine the factors associated with selection of antimicrobials by dairy veterinarians, and attitudes those veterinarians farmers to antimicrobial usage resistance.Facilitated focus groups (n=22) an anonymous online survey cattle (n=206 respondents) were used prescribing behaviour, affecting antimicrobials, use risk resistance (AMR).Amongst 22 farmers, most common primary reason for choosing was veterinary advice (87%) followed personal experience (68%). Farmers had limited knowledge or...
Bovine brucellosis, primarily caused by Brucella abortus, severely affects both animal health and human well-being. Accurate diagnosis is crucial for designing informed control prevention measures. Lacking a gold standard test makes it challenging to determine optimal cut-off values evaluate the diagnostic performance of tests. In this study, we developed novel Bayesian Latent Class Model that integrates binary continuous testing outcomes, incorporating additional fixed (parity) random...
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Abstract Background An elevation in resting venous blood lactate levels ([La-]b) conditions of myocardial hypoperfusion is associated with adverse prognosis and survival. This investigation aimed to assess changes [La-]b induced by dobutamine stress the presence absence ischaemia outcomes at 1-year. Methods 404 consecutive patients (mean age 70±10 years, 243 male) reporting chest pain underwent echocardiography were categorised as ischaemic (IS) or non-ischaemic (NI) responders. Conventional...
This study tested the hypothesis that increasing duration and/or frequency of antimicrobial treatment subclinical mastitis would result in a higher bacteriological cure rate. Glands with positive California test (CMT) from cows an elevated somatic cell count (>500,000 cells/mL) had intramammary infection were randomly assigned at cow level to no (Control; n = 80 glands), infusion 200 mg cloxacillin sodium on three occasions 48 h intervals (3 × h; 273 five 24 (5 279 or 72 glands). resampled...
Chronic obstructive pulmonary disease (COPD) is characterized by varying trajectories of decline. Information regarding the prognostic value preventing short-term clinically important deterioration (CID) in lung function, health status, or first moderate/severe exacerbation as a composite endpoint worsening needed. We evaluated post hoc link between early CID and long-term adverse outcomes.CID was defined ≥100 mL decrease forced expiratory volume 1 s (FEV1), ≥4-unit increase St George's...
Firstly, to define, in dairy cows the first 5 weeks post-calving fed a predominantly pasture-based diet, cut-points of concentrations beta-hydroxybutyrate (BHBA) blood, above which there were associations with purulent vaginal discharge (PVD), reduced pregnancy rates (PR) and decreased milk production, order better define subclinical ketosis (SCK) such cattle; secondly, determine prevalence, incidence risk factors for SCK.An observational field study was conducted 565 from 15 spring-calving...
The main aim of this study was to describe the prevalence primary subclinical ketosis (SCK) in mainly pasture-grazed dairy cows three dairy-farming regions New Zealand 7-12, and 35-40 days post-calving. A second investigate herd- cow-level factors associated with SCK.A cross-sectional longitudinal survey undertaken 1,620 from 57 herds. random sample without disease prior 30 were enrolled at one farm visit within 5 calving, blood samples collected 7 28 later (7-12 post-calving) for...
Ewe wastage is the combination of on-farm mortality and premature culling. Internationally, there limited research on actual incidence causes in commercial sheep flocks. To authors’ knowledge, this first study that reports both lifetime detailed annual a sample New Zealand This utilized data collected from 13,142 ewes four cohorts three farms (Farm A 2010-born, Farm 2011-born, B, C), during period 2011–2017, as they aged replacement hoggets to 6-year-old B) or 3-year-old C). Data collection...
Abstract AIM: To describe aspects of management dairy heifers before calving and determine risk factors for clinical mastitis postpartum in heifers, at the herd level, under pasture-based systems Waikato Taranaki regions New Zealand. METHODS: Dairy herdowners (n=578) provided information via a prospective survey about their practices rearing mastitis. A proportion (n=250) subsequently data on cases herds, including date, cow identification, age quarter affected from occurring 4 months after...
The main aim was to investigate the effectiveness of a novel internal teat sealant (ITS) formulation containing bismuth subnitrate and antiseptic chlorhexidine, in adult cows (Trial A) nulliparous heifers B), reduce incidence new intramammary infection (IMI) between treatment calving prevalence IMI within 6 days following calving.In Trial A dairy (n=326) without history clinical mastitis with maximum composite milk somatic cell count <200,000 cells/mL during current lactation were enrolled...
Aims: To examine a range of udder and teat traits in Romney ewes to describe the frequency with which different scores occur, investigate associations between lamb survival weaning ewe scores. Methods: Mixed-age, mature (n = 1,009) were enrolled from commercial sheep flock located Wellington region New Zealand January 2017. A scored all ewes, using visual assessment palpation, at pre-mating (February), pre-lambing (October), docking (November) (January 2018). During lambing period each...