A5034104369- Antibiotic Resistance in Bacteria
- Infections and bacterial resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial Community Ecology and Physiology
- Endodontics and Root Canal Treatments
- Genomics and Phylogenetic Studies
- Bacterial biofilms and quorum sensing
- Computational Drug Discovery Methods
- Oral microbiology and periodontitis research
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Bacterial Identification and Susceptibility Testing
- Ginger and Zingiberaceae research
- Animal Genetics and Reproduction
- Plant Pathogenic Bacteria Studies
- Antibiotic Use and Resistance
- Phenothiazines and Benzothiazines Synthesis and Activities
- Vibrio bacteria research studies
- Dental Radiography and Imaging
- Reproductive biology and impacts on aquatic species
- melanin and skin pigmentation
- Infective Endocarditis Diagnosis and Management
- Aquaculture disease management and microbiota
- vaccines and immunoinformatics approaches
- Piperaceae Chemical and Biological Studies
Siksha O Anusandhan University
2021-2024
Central Tuber Crops Research Institute
2024
Czech Agrifood Research Center
2024
The river Ganges in India has faced considerable issues due to water quality degradation caused by various anthropogenic activities. This study employs metagenomic analysis comprehensively characterize bacterial communities, explore functional genomics, and investigate the prevalence of virulence factors antibiotic resistant genes (ARGs) within sediment environment Ganges. Taxonomic profiling revealed that proteobacteria were most dominating phyla found all samples, whereas abundance...
The global rise in antibiotic resistance, fueled by indiscriminate usage medicine, aquaculture, agriculture, and the food industry, presents a significant public health challenge. Urban wastewater sewage treatment plants have become key sources of resistance proliferation. present study focuses on river Ganges India, which is heavily impacted human activities serves as potential hotspot for spread resistance. We conducted metagenomic analysis sediment samples from six distinct locations...
Morganella morganii is a Gram-negative opportunistic Enterobacteriaceae pathogen inherently resistant to colistin. This species causes various clinical and community-acquired infections. study investigated the virulence factors, resistance mechanisms, functional pathways, comparative genomic analysis of M. strain UM869 with 79 publicly available genomes. The multidrug harbored 65 genes associated 30 including efflux pump, hemolysin, urease, adherence, toxin, endotoxin. Additionally, this...
The emergence of Multidrug resistance (MDR) in human pathogens has defected the existing antibiotics and compelled us to understand more about basic science behind alternate anti-infective drug discovery. Soon, proteome analysis identified AcrB efflux pump protein as a promising target using plant-driven phytocompounds used traditional medicine systems with lesser side effects. Thus, present study aims explore novel, less toxic, natural inhibitors Klebsiella pneumoniae from 69 Zingiber...
The rapid emergence of MDR Klebsiella pneumoniae demands alternative therapy. 6-Gingerol is a natural phytocompound that has synergistic and bactericidal effects against MDR-KP isolates. It exhibited promising EPI activity to stop colistin efflux.
Genes conferring antibiotic resistance phenotype, particularly to last resort antibiotics, pose a significant concern globally. Wastewater treatment plant (WWTP) effluent substantially contributes in receiving rivers, threatening human health. Globally, colistin- and carbapenem-resistant Klebsiella pneumoniae infections cause high morbidity mortality. We investigated colistin-resistant carbapenemase-producing K. (Co-CRKP) isolates Kathajodi river WWTP effluent, their genes, pathogenic...
For the first time, we describe whole genome of a yellow-pigmented, capsule-producing, pathogenic, and colistin-resistant Chryseobacterium gallinarum strain MGC42 isolated from patient with urinary tract infection in India. VITEK 2 automated system initially identified this isolate as C. indologenes . However, 16S rRNA gene sequencing revealed that shared 99.67% sequence identity –type DSM 27622. The draft was 4,455,926 bp long 37.08% Guanine-Cytosine (GC) content devoid any plasmid....
Thermal springs have been the most resourceful ecological niches to understand intricacies of microbial community structure building. In present study, was investigated in five ecologically different hot springs. The highest number OTUs observed at low temperatures (42 °C) whereas an increasing unclassified bacteria with a temperature rise. statistical correlation predicted that temperature, total dissolved solids and ions were primary environmental factors controlling composition diversity....
Primary apical periodontitis occurs due to various insults the dental pulp including microbial infections, physical and iatrogenic trauma, whereas inadequate elimination of intraradicular infection during root canal treatment may lead secondary periodontitis. We explored complex intra-radicular communities their functional potential through genome reconstruction. applied shotgun metagenomic sequencing, binning profiling identify significant contributors at acute chronic periodontal lesions....
The present study revealed the emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) and associated driving factors in an urban river system surrounding Cuttack city, Odisha. high contamination factor degree indicate poor water quality. CRKP isolates showed 100% resistance against piperacillin, amoxicillin-clavulanic acid, piperacillin-tazobactam, ceftriaxone, ceftazidime, meropenem, imipenem but less to colistin (12.85%). Among isolates, carbapenemase genes blaNDM, blaOXA-48-like,...
Growing multi-drug resistance (MDR) among ESKAPE pathogens is a huge challenge. Increased to last-resort antibiotics, like colistin, has further aggravated this. Efflux identified as major route of colistin resistance. So, finding an FDA-approved efflux inhibitor for potential application adjuvant was the primary objective this study.
Background: In the dynamic progression of root canal infections, resultant change in environmental conditions directs adaptation microbiome terms richness, evenness, and diversity. Objective: The goal this study is to contrast interradicular bacterial community structures teeth acute chronic stages investigate potential microorganisms associated with persistent apical periapical infections. Methods: Interradicular samples were collected from 10 periodontitis group group. High-throughput...