A5091351166- Tuberculosis Research and Epidemiology
- vaccines and immunoinformatics approaches
- Pneumonia and Respiratory Infections
- Infectious Diseases and Mycology
- Advanced Proteomics Techniques and Applications
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Influenza Virus Research Studies
NIHR Southampton Biomedical Research Centre
2024
University of Southampton
2019-2024
Southampton General Hospital
2019
Hampshire Hospitals NHS Foundation Trust
2015
BACKGROUND. Tuberculosis (TB) kills more people than any other infection, and new diagnostic tests to identify active cases are required. We aimed discover verify novel markers for TB in nondepleted plasma.
BACKGROUNDNovel biomarkers to identify infectious patients transmitting Mycobacterium tuberculosis are urgently needed control the global (TB) pandemic. We hypothesized that proteins released into plasma in active pulmonary TB clinically useful distinguish cases from healthy individuals and with other respiratory infections.METHODSWe applied a highly sensitive non-depletion tandem mass spectrometry discovery approach investigate protein expression compared controls South African Peruvian...
Abstract The frequency of isolation non-tuberculous mycobacteria (NTM) species from respiratory specimens is increasing, however the clinical relevance such identifications vary by mycobacterial and geographical location. A retrospective study 853 NTM isolates samples 386 patients over seven years was performed. Clinical records radiographic information were examined. significance assessed American Thoracic Society diagnostic criteria. 25% all with met criteria for pulmonary disease...