A5009230662- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Organ Transplantation Techniques and Outcomes
- CAR-T cell therapy research
- Wireless Body Area Networks
Vall d'Hebron Institut de Recerca
2024
Banc de Sang i Teixits
2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2024
Hospital Clínic de Barcelona
2024
In advanced chronic liver disease (ACLD), deregulated hepatic necroinflammatory processes play a key role in the development of microvascular dysfunction, fibrogenesis, and increased vascular tone, resulting progression ACLD portal hypertension. Given current lack an effective treatment, we aimed to characterise effects pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist lanifibranor 2 preclinical models ACLD, as well cells from patients with ACLD.Cirrhotic rats (thioacetamide...
<title>Abstract</title> <bold>Background:</bold> Chronic liver disease is a major health concern, but sex-specific differences in its pathophysiology remain unclear. Preclinical studies have predominantly used male animals, limiting findings' relevance to both sexes. This project aimed explore sex cirrhosis and portal hypertension (PH) rats, find similarities human samples for translational relevance. <bold>Methods:</bold> Advanced chronic (ACLD) was induced female Sprague-Dawley rats using...
Adoptive cell therapy using virus‐specific T cells (VST) is a strategy for treating common opportunistic viral infections after transplantation, particularly when these do not resolve through antiviral drug therapy. The availability of third‐party healthy donors allows the immediate use allogeneic in cases where patients lack an appropriate donor. Here, we present creation donor registry human leukocyte antigen (HLA)‐typed blood donors, REDOCEL, strategic initiative to ensure compatible...