Systemic sclerosis (SSc) may overlap with systemic lupus erythematous (SLE). Little is known about the epidemiology, clinical characteristics, and survival of SSc-SLE overlap. We evaluated prevalence differences in SSc compared without SLE.A cohort study was conducted including subjects who fulfilled American College Rheumatology (ACR)/European League Against Rheumatism classification criteria for and/or ACR SLE. The primary outcome time from diagnosis to all-cause mortality. Survival using...

Sodium-glucose cotransporter 2 (SGLT2) inhibitors, also known as Gliflozins, are a class of anti-diabetic medications initially developed for glycemic control in patients with type diabetes mellitus (T2DM). T2DM at significantly higher risk adverse outcomes, including heart failure, atherosclerotic cardiovascular disease, and renal diseases. Unlike traditional hypoglycemic agents, SGLT2 inhibitors have demonstrated notable benefits. Four inhibitors-Canagliflozin, Empagliflozin,...

Objective: This study aimed to assess the association between hemoglobin levels and in-hospital outcomes in patients with ST-segment elevation myocardial infarction (STEMI) at King Abdullah Medical City (KAMC). Methods: was a retrospective cohort of 1,027 consecutive STEMI patients, from July 2022 March 2023. The divided into two groups according presence anemia on admission. Anemia defined as 12 g/dL women 13 men: group 1 (255 (24.8%)) 2 without (772 (75.2%)). Multiple logistic regression...

Rationale: Remitting seronegative symmetric synovitis with pitting edema is a rare, benign disorder symmetrically affecting the peripheral joints. It begins acute-onset on dorsum of hands and feet, primarily affects elderly men has favorable response to low-dose steroids. may also be paraneoplastic symptom an underlying hidden cancer; hence, thorough clinical evaluation required. Patient concerns: A 58-year-old woman who presented polyarthritis both feet. Based laboratory findings, remitting...

Objectives: To study the prevalence of injuries among padel players in Madinah and investigate potential causes. This makes an attempt to add gaps literature regarding injury risks preventive strategies this fast-growing sport. Methods: Retrospective cross-sectional on 305 who come from Madinah, consisting 193 men 112 women aged 18–40 years. Data were collected using online Google Forms questionnaire, including descriptive statistics non-parametric tests, which chi-square test was performed,...

Background Epidemiological studies indicate that vitamin D deficiency may increase the risk of developing autoimmune and chronic diseases such as rheumatoid arthritis (RA) and, therefore, is prevalent in patients with RA. Additionally, insufficiency associated significant disease activity This study aimed to assess prevalence Saudi RA determine whether there an association between low levels activity. Methodology cross-sectional retrospective was conducted from October 2022 November on who...

Depression is the most common psychiatric disorder associated with rheumatoid arthritis (RA). However, little known about its prevalence and risk factors among Saudi patients, specifically. Therefore, this study sought to determine predictors of depression in patients RA Arabia.A cross-sectional was conducted registered at Charitable Association for Rheumatic Diseases. Inclusion criteria were that either met American College Rheumatology 1987 revised classification or 2010 criteria....

Thrombotic Thrombocytopenic Purpura (TTP) is a critical medical condition characterized by thrombocytopenia, hemolytic anemia, and organ damage due to microvascular clotting. This review delves into TTP's epidemiology, clinical presentation, treatment methods. Advances in understanding the disease's pathophysiology have allowed significant improvements management strategies. The shift from traditional therapies like therapeutic plasma exchange corticosteroids innovative, targeted treatments...

Menstrual irregularities during isotretinoin therapy, including amenorrhea, can cause a great deal of health-status uncertainty such as the possibility pregnancy. This study aimed to evaluate effects treatment on menstrual cycle. cross-sectional was conducted among females aged between 15–45 years taking for acne. Descriptive statistics were used in form frequencies and percentages represent categorical variables. Pearson’s chi-squared test performed assess relationship some variables with...

Urticarial vasculitis is an eruption of erythematous wheals that clinically resemble urticaria but histologically show changes leukocytoklastic vasculitis. In association with connective tissue disease it most commonly seen complicating Systemic lupus (SLE) and, less often, Sjogren's syndrome. Here, we report a 25-year-old woman who developed SLE in 1998. May 2013 she presented urticarial vasculitis; her skin biopsy was consistent leukocytoclastic She also bilateral uveitis. had the clinical...

Monkeypox is an evolving zoonotic disease which caused by the monkeypox virus. In recent times number of cases across globe has increased. The was previously endemic to Africa but now spreading worldwide. More than 62,000 were reported 104 countries. illness typically incubation period 7 14 days and symptoms such as fever, headache, fatigue, myalgia, generalized body aches, lymph node enlargement, skin lesions are common. similar smallpox, lymphadenopathy characteristic feature monkeypox....

A variety of viruses and bacteria can cause upper respiratory tract infections. These a patient diseases including acute bronchitis, the common cold, influenza, distress syndromes. Defining most these is difficult because presentations connected with infections commonly overlap their causes are similar. Upper characterized as self-limiting irritation oedema tract, along coughing no evidence pneumonia, in without background chronic obstructive pulmonary disease, emphysema, or bronchitis any...

Wilsons disease is a disorder that occurs when there are mutations, in the ATP7B gene. This leads to problems with copper transport and metabolism body. In this review we explore causes, effects, symptoms management of disease. We delve into factors contribute condition how it affects livers’ ability handle copper. A key diagnostic feature presence "sunset glow" hepatocytes indicating buildup The manifests affecting organs such as liver nervous system, mind, blood, kidneys eyes. Due range an...

Primary adrenal insufficiency (PAI), also referred to as Addison's disease (AD), is a rare but potentially life-threatening disorder marked by deficiency in the production of hormones cortex. Despite significant advancements diagnosis and treatment, challenges remain, particularly pediatric cases where diagnostic delays are common. Autoimmune adrenalitis leading cause AD adults, while congenital hyperplasia (CAH) due 21-hydroxylase primary children. Recent developments include dual-release...

Background: Metformin is an oral anti-diabetic drug widely recognized as the first-line therapy in treatment of Type 2 Diabetes Mellitus (T2DM) Aim: To assess impact metformin on glycemic control, insulin dosage, and side effects poorly controlled, insulin-treated type diabetes patients. Patients methods: A comprehensive literature search was conducted using electronic databases such PubMed, Embase, Cochrane Library, Web Science. The terms included "metformin," "insulin," "type diabetes,"...

An unprecedented challenge to the healthcare system worldwide has resulted from coronavirus disease 2019 (COVID-19) pandemic. As per estimates of year 2022 over 314 million cases and 5.5 deaths had been reported since pandemic began. The respiratory is primary affected by COVID-19, which a multisystem disease. It usually starts as an upper infection that spreads lungs causes interstitial pneumonia, severe failure, systemic inflammatory response, multi-organ dysfunction in most extreme...

<h3>Background</h3> Systemic sclerosis (SSc) is an immune disorder characterised by vasculopathy and fibrosis that may overlap with another disease such as systemic lupus erythematous (SLE). Little known about the epidemiology, clinical characteristics, survival of SSc-SLE (also called lupoderma). We evaluated prevalence syndrome, differences in SSc characteristics compared without SLE. <h3>Methods</h3> A cohort study was conducted including subjects who fulfilled ACR-EULAR classification...

Rationale: Adult-onset Still disease (AOSD) is a systemic autoinflammatory illness of unknown cause. Its manifestations comprise fever; arthritis or arthralgia; and skin rash with high inflammatory markers ferritin levels. Coronavirus 2019 (COVID-19) shares several clinical features laboratory AOSD: making it challenging to differentiate between the 2 conditions. Patient concerns: A 29-year-old woman presented fever, rash, polyarthritis 4 weeks before admission. Two after onset, she had an...