A5000802072- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Dysphagia Assessment and Management
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Cardiac tumors and thrombi
- Hearing, Cochlea, Tinnitus, Genetics
- Protease and Inhibitor Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Pediatric health and respiratory diseases
- Sulfur Compounds in Biology
- IL-33, ST2, and ILC Pathways
- Ear and Head Tumors
- Pericarditis and Cardiac Tamponade
- Vascular Malformations and Hemangiomas
- Occupational and environmental lung diseases
- Urinary and Genital Oncology Studies
- Hearing Loss and Rehabilitation
- Olfactory and Sensory Function Studies
- Respiratory Support and Mechanisms
Our Lady's Hospital
2018-2019
Royal College of Surgeons in Ireland
2011-2016
Beaumont Hospital
2011-2015
Tallaght University Hospital
2013-2014
Mater Misericordiae University Hospital
2014
Our Lady of Lourdes Hospital
2014
Molecular Medicine Ireland
2012
Cystic Fibrosis (CF) is a genetic disease characterised by deficit in epithelial Cl− secretion which the lung leads to airway dehydration and reduced Airway Surface Liquid (ASL) height. The endogenous lipoxin LXA4 member of newly identified eicosanoids playing key role ending inflammatory process. Levels are reported be decreased airways patients with CF. We have previously shown that normal human bronchial cells, produced rapid transient increase intracellular Ca2+. investigated, effect on...
In cystic fibrosis (CF), the airway surface liquid (ASL) height is reduced as a result of impaired ion transport, which favors bacterial colonization and inflammation leads to progressive lung destruction. Lipoxin (LX)A4, promotes resolution inflammation, inadequately produced in airways patients with CF. We previously demonstrated that LXA4 stimulates an ASL increase epithelial repair. Here we report molecular mechanisms involved these processes. found (1 nM) induced apical ATP release from...
Renal cell carcinoma (RCC) metastasis to the urinary bladder has been a rarely reported clinical entity, and its potential metachronous pathobiological process poses significant challenges in RCC therapy-transforming scenarios. In this case, we share experience of female patient who underwent radical nephrectomy September 2020 was on regular follow-up. March 2022, she found have right pulmonary PET-CT imaging accordingly right-sided wide local excision lung lesion by thoracoscopy June which...
In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously demonstrated that lipoxin A4 (LXA4) can modulate ASL height (ASLh) through actions on Cl(-) transport. Here, we report novel effects of epithelial Na(+) channel ENaC in this response. dynamics and ion transport were studied using live-cell confocal microscopy short-circuit current measurements CF (CuFi-1) non-CF (NuLi-1) cell cultures. Low physiological concentrations LXA4 picomolar range produced an increase...
Pleural fluid analysis yields important diagnostic information in pleural effusions combination with clinical history, examination, and radiology. For more than 30 years, the initial most pragmatic step this process is to determine whether a transudate or an exudate. Light's criteria remain robust separating transudate-exudate classification which dictates further investigations management. Recent studies have led evaluation implementation of number additional analyses that may improve...
Asthma is a chronic airway disease characterized by inflammation, bronchial hyperresponsiveness and airflow obstruction. Patients with persistent symptoms despite maximum standard treatment as per Global Initiative of guidelines are considered to have severe asthma. Omalizumab recombinant humanized monoclonal antibody licenced for use an add-on therapy in these patients.To assess the clinical benefit amongst responders omalizumab at tertiary referral centre.This was retrospective audit...
A 22-year-old woman presented with symptoms and signs consistent acute severe asthma. After significant doses of beta-agonist, she developed a lactic acidosis. Significant issues arose in this patient's history regards to purchase medications, compliance follow-up respiratory service. Beta-adrenergic receptors when stimulated have been hypothesised increase lipolysis, producing free fatty acids, which inhibit the conversion pyruvate coenzyme within Krebs cycle. Additional is generated...
Acid-sensing ion channels (ASIC) are a family of acid-activated ligand-gated cation channels. As tissue acidosis is feature inflammatory conditions, such as allergic rhinitis (AR), we investigated the expression and function these in AR.The aim study was to assess ASIC nasal mucosa control AR subjects.Immunohistochemical localization receptors functional responses lactic acid application were investigated. In vitro studies on cultured epithelial cells performed underlying mechanisms...
We have investigated the role of endogenous anti-inflammatory lipoxin LXA4 in modulating Cl− secretion and Na+ absorption, airway surface liquid height (ASLh) ciliary beat frequency (CBF) CF non-CF bronchial epithelia. (CuFi-1) (NuLi-1) epithelial cell lines were grown under an air-surface interface into well-differentiated ASLh CBF measured using confocal fluorescence microscopy ion transport patch-clamp short-circuit current techniques. (1nM) treatment for 15 minutes, increased by 47.5±0.5...
Abstract Background A history of a previous fall is one the best predictors future falls, increasing its risk 3-fold. The Health Service Executive (HSE) practice guidelines recommend that all patients aged over 65 years in contact with healthcare professionals should be asked routinely whether they have fallen past year and about fall-frequency, context characteristics. aim this audit was to increase falls recognition by medical following implementation screening questionnaire into admission...
Abstract Background The National Clinical Guidelines and Recommendations for the Care of People with Stroke recommend that if an initial screen a patient acute stroke indicates swallowing difficulties, should have specialist swallow assessment within 24 hours admission not more than 72 afterwards. aim this audit was to reassess rate in group following introduction full-time speech hospital. Methods This clinical where all patients who presented stroke, screening indicated problems were...