A5101557861- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Advanced Fluorescence Microscopy Techniques
- Luminescence Properties of Advanced Materials
- Electrowetting and Microfluidic Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Cells and Metastasis
- Perovskite Materials and Applications
- Carbon and Quantum Dots Applications
- Nanocluster Synthesis and Applications
- Molecular Sensors and Ion Detection
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- Supramolecular Chemistry and Complexes
- Force Microscopy Techniques and Applications
- Electrochemical sensors and biosensors
- Lipid Membrane Structure and Behavior
- 3D Surveying and Cultural Heritage
- Innovative Microfluidic and Catalytic Techniques Innovation
- Photoacoustic and Ultrasonic Imaging
- Animal Diversity and Health Studies
- Photonic Crystals and Applications
- Nonlinear Optical Materials Studies
Hangzhou Normal University
2025
Open University of China
2024
The Open University
2024
Jacksonville College
2024
Mayo Clinic in Florida
2024
University of Washington
2017-2023
Seattle University
2018-2022
Purdue University West Lafayette
2020
Jilin University
2014-2017
State Key Laboratory on Integrated Optoelectronics
2014-2017
There has been great progress in the development of fluorescence biosensors based on quantum dots (QDs) for detection lead ions. However, most methods are detecting ions aqueous solution rather than human serum due to influence protein autofluorescence excited by visible light. Thus, we developed a novel resonance energy transfer (FRET) biosensor choosing upconversion NaYF4:Yb3+/Tm3+ nanoparticles as donor and CdTe QDs acceptor ion detection. It is first near infrared (NIR)-excited...
A dynamic cross-linked supramolecular network of poly(glycidyl methacrylate)s derivative chains was constructed on mesoporous silica nanoparticles via disulfide bond and ion–dipole interactions between cucurbit[7]urils protonated diamines in the polymer chains. This kind multifunctional organic–inorganic hybrid material with pH- glutathione- (GSH-) stimuli responsiveness can be applied to anticancer drug delivery controlled release. Good release performance toward doxorubicin hydrochloride...
Lead halide perovskites are widely used for optoelectronic devices because they possess a high charge carrier mobility, photoconversion efficiency, low energy cost, etc. However, lead toxicity and instability of these prevent their wide-scale industrial applications. Herein, we successfully fabricated the lead-free Ce3+ doped Cs3MnBr5 metal nanocrystals (MHNCs), which displays broad UV response an efficient blue photoluminescence at 398 423 nm. The introduction ions results in broadband to...
Drawing architectural plan is a crucial step in the preservation of ancient Chinese building. This process often time-consuming and typically carried out by skilled human. paper presents method for automatically extracting line art building structures, which significantly enhances efficiency creating plans. We first introduce dataset images featuring Huizhou-style buildings. Each image then segmented into various components to identify main structure. The SUPIR model can optionally be...
The design and fabrication of a self-digitization dielectrophoretic (SD-DEP) chip with simple components for single-cell manipulation downstream nucleic acid analysis is presented. device employed the traditional DEP insulator to create local electric field that tailored approximately size single cells, enabling highly efficient capture. multistep procedures cell manipulation, compartmentalization, lysis, were performed in integrated microdevice, consuming minimal reagents, minimizing...
Sensitive and accurate quantification of HIV RNA could be achieved using digital NASBA in an SD-chip.
The ability to sort and dispense droplets accurately is essential droplet-based single-cell analysis. Here, we describe a fluorescence-activated single-droplet dispenser (FASD) that analogous conventional cell sorter, but sorts containing single cells within an oil emulsion. FASD system uses cytometric detection electrohydrodynamic actuation-based manipulation, allowing droplet isolation dispensing with high efficiency accuracy. compatible multiwell plates can be integrated existing...
Efficient targeting is a major challenge in practical photodynamic therapy (PDT). Though the "enhanced permeability and retention" (EPR) effect widely used tumor method, magnetic strategy more promising considering issue of high efficiency reducing concentration-dependent toxicity. Herein, highly effective Fe3O4@Ce6/C6@silane NPs are reported as class precisely controlled photosensitizers (PS) for PDT. On basis amphiphilic silane encapsulation, PS chlorin e6 (Ce6) Coumarin 6 (C6) well Fe3O4...
Abstract Mesoporous silica nanoparticles (MSNs) have been functionalized with supramolecular switches, composed of cleavable disulfide bond‐containing alkylammonium stalks encircled by water‐soluble sulfonatocalix[4,6]arenes, to result in smart mechanized MSNs. Cargo can be encased tightly the nanopores these MSNs their closed state, but are released efficiently either response L‐glutathione (GSH), cleaving bonds stalks, or pH variation, turning on calixarene‐based switches. The higher...
Abstract. This paper presents a framework of introducing GIS technology to record and analyse cultural heritages in continuous spatial scales. The research team is developing systematic approach support heritage conservation practice on historical buildings, courtyards, towns, archaeological sites ad landscapes. These studies are conducted not only from the property or site scales, but also investigated their contexts setting as well regional From these continues authenticity integrity can...
Herein, we report a facile route to synthesize silane coated upconversion nanoparticles (UCNPs@silane) with an ultrathin layer (the thickness: 1-2 nm), which not only provides good biocompatibility, but also affords hydrophobic interspace load organic molecules realize multifunctions. Besides the function of imaging UCNPs, cancer therapy and oxygen level detection can be realized by addition chemotherapy drug, PTX, sensitive molecules, Platinum (II) octaethylporphine (PtOEP). In...
Abstract Impaired glucose metabolism in diabetes causes severe acute and long‐term complications, making real‐time detection of blood indispensable for diabetic patients. Existing continuous monitoring systems are unsuitable clinical glycemic management due to poor stability. Polymer dot (Pdot) transducers implantable optical nanosensors that exhibit excellent brightness, sensitivity, selectivity, biocompatibility. Here, it is shown hydrogen peroxide—a product oxidation Pdot sensors—degrades...
Deep in vivo imaging of vasculature requires small, bright, and photostable fluorophores suitable for multiphoton microscopy (MPM). Although semiconducting polymer dots (pdots) are an emerging class highly fluorescent contrast agents with favorable advantages the next generation imaging, their use deep MPM has never before been demonstrated. Herein, we characterize properties three pdot variants perform cortical rodent microvasculature. We find brightness exceeds conventional fluorophores,...
The undesirable immune response poses a life-threatening challenge to human health. It not only deteriorates the therapeutic performance of biologic drugs but also contributes various diseases such as allergies and autoimmune diseases. Inspired by role chromatin in maintenance natural tolerance, here we report DNA-protein polymeric nanocomplex that can mimic tolerogenic function induce an tolerance its protein cargos. We first proved chromatin-mimetic nanomedicine loaded with keyhole limpet...
Abstract The design and fabrication of a self‐digitization dielectrophoretic (SD‐DEP) chip with simple components for single‐cell manipulation downstream nucleic acid analysis is presented. device employed the traditional DEP insulator to create local electric field that tailored approximately size single cells, enabling highly efficient capture. multistep procedures cell manipulation, compartmentalization, lysis, were performed in integrated microdevice, consuming minimal reagents,...