A5089335322- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Neuroblastoma Research and Treatments
- SARS-CoV-2 detection and testing
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Polyomavirus and related diseases
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
University of Pennsylvania
2022-2024
Mayo Clinic in Arizona
2020
Abstract Adeno‐associated virus (AAV)‐based gene therapies are in clinical development for haemophilia and other genetic diseases. Since the recombinant AAV genome primarily remains episomal, it provides opportunity long‐term expression tissues that not proliferating reduces safety concerns compared with integrating viral vectors. However, integration events detected at a low frequency. Preclinical studies mouse models have reported hepatocellular carcinoma (HCC) after systemic...
The viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly its cell-binding spike protein gene, has undergone rapid evolution during the disease 2019 (COVID-19) pandemic. Variants including Omicron BA.1 and BA.2 now seriously threaten efficacy therapeutic monoclonal antibodies vaccines that target protein. Viral over a much longer timescale generated wide range genetically distinct sarbecoviruses in animal populations, pandemic viruses SARS-CoV-2...
Abstract The viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly its cell-binding spike protein gene, has undergone rapid evolution during the disease 2019 (COVID-19) pandemic. Variants including Omicron BA.1 and BA.2 now seriously threaten efficacy therapeutic monoclonal antibodies vaccines that target protein. Viral over a much longer timescale generated wide range genetically distinct sarbecoviruses in animal populations, pandemic viruses SARS-CoV-2...