A5061518524- RNA regulation and disease
- Virus-based gene therapy research
- Microbial Metabolism and Applications
- Retinal Development and Disorders
- CRISPR and Genetic Engineering
- Neuroethics, Human Enhancement, Biomedical Innovations
- HIV-related health complications and treatments
- Viral Infectious Diseases and Gene Expression in Insects
- HIV/AIDS oral health manifestations
- Pneumocystis jirovecii pneumonia detection and treatment
- Space Science and Extraterrestrial Life
- Plant biochemistry and biosynthesis
HiFiBiO Therapeutics (France)
2025
University of Florence
2001
Aims/Purpose: Complement inhibitors slightly reduce geographic atrophy (GA) lesion growth, yet vision loss prevention remains a challenge. Iron overload worsens retinal diseases like age‐related macular degeneration (AMD), and Transferrin (Tf) supplementation mitigates iron‐induced toxicity, offering promising therapy for GA (Picard 2015). To avoid repeated intravitreal Tf injections, we developed non‐viral vectorized delivery platform via electrotransfection of the ciliary muscle, acting as...
Dysregulation of iron metabolism is observed in animal models retinitis pigmentosa (RP) and patients with age-related macular degeneration (AMD), possibly contributing to oxidative damage the retina. Transferrin (TF), an endogenous chelator, was proposed as a therapeutic candidate. Here, efficacy TF non-viral gene therapy based on electrotransfection pEYS611, plasmid encoding human TF, into ciliary muscle evaluated several rat retinal degeneration. pEYS611 administration allowed for...
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