A5010495620- Insect symbiosis and bacterial influences
- Entomopathogenic Microorganisms in Pest Control
- Genetics and Plant Breeding
- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Agricultural Economics and Practices
- Livestock Management and Performance Improvement
- Wheat and Barley Genetics and Pathology
- Crop Yield and Soil Fertility
- Animal Diversity and Health Studies
- Seed Germination and Physiology
- Insect and Pesticide Research
- Plant Genetic and Mutation Studies
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Soybean genetics and cultivation
- Immune Cell Function and Interaction
- Healthcare and Venom Research
- Milk Quality and Mastitis in Dairy Cows
- Livestock and Poultry Management
- Plant tissue culture and regeneration
- Insect behavior and control techniques
- Adenosine and Purinergic Signaling
- Psoriasis: Treatment and Pathogenesis
- Aquaculture disease management and microbiota
23andMe (United States)
2024-2025
Indian Agricultural Research Institute
1974-2023
University of Delhi
2023
National Research Centre on Plant Biotechnology
2023
Indian Institute of Vegetable Research
2023
Central Salt and Marine Chemicals Research Institute
2022
Molecular Medicine Research Institute
2020-2021
George Washington University
2015-2019
Indian Council of Agricultural Research
2018
Tilka Manjhi Bhagalpur University
2017
Symbiotic interactions between microbes and animals are common in nature. organisms particularly insects and, some cases, they may protect their hosts from pathogenic infections. Wolbachia Spiroplasma endosymbionts naturally inhabit various including Drosophila melanogaster fruit flies. Therefore, this symbiotic association is considered an excellent model to investigate whether endosymbiotic bacteria participate host immune processes against certain pathogens. Here we have investigated the...
The study investigates the significance of indigenous games in education among Nagas, an community inhabiting North-Eastern region India. Through primary and secondary sources, paper discusses how are knotted with Naga context. results findings is discussed based on literature review interaction elders society who well versed methods importance society. reflects role its implications preserving transmitting cultures across generations. It explores value teaching learning various life skills...
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<p>Supplementary Figure S6</p>
<p>Characterization of the binding and blocking activity 23ME-01473</p>
<p>Supplementary Figure S7</p>
Abstract The landscape of cancer treatment has been transformed by immune checkpoint inhibitors; however, the failure to benefit a large number patients with underlined need identify promising targets for more effective interventions. In this study, we leverage 23andMe, Inc.’s large-scale human germline genetic and health database uncover previously unknown role UL16-binding protein 6 (ULBP6), high-affinity NK group 2D (NKG2D) ligand, in its promise as an immuno-oncology therapeutic target....
<p>List of collaborators from 23andMe Research Team</p>
<p>23ME-01473 significantly inhibits the growth of a NSCLC patient-derived xenograft cancer model <i>in vivo.</i><b>A,</b> Cell surface expression ULBP6/2/5 on EpCAM<sup>+</sup> tumor cells from CTG-3470 PDX cell line implanted and grown in NOG mice as measured by flow cytometry. Data three biological replicates are shown. <b>B,</b> Representative IHC images or MICA/B (top) corresponding isotype controls (bottom) resected tumors....
<p>Supplementary Figure S3</p>
<p>Dual FcγRIIIa and NKG2D activation by 23ME-01473, an Fc effector–enhanced anti-ULBP6/2/5 antibody, induces augmented antitumor immunity. <b>A,</b> IFNγ concentration of the supernatants IL-2/IL-15–primed PBMCs cultured with plate-bound antibodies that activate (Fc-WT-anti-lysozyme antibody; X-lys-E+), (Fc-Att-anti-lysozyme antibody fused to ULBP6-02; ULBP6-lys-E−), both receptors ULBP6-lys-E+), or neither receptor X-lys-E−) for 24 hours. Data represent mean ± SD three...
<p>Supplementary Figure S1</p>
<p>mRNA and protein expression of NKG2D ligands in human cancers. <b>A,</b> Heatmap the median mRNA NKG2DLs per cancer type The Cancer Genome Atlas. types are sorted by <i>RAET1L</i> (ULBP6). <b>B,</b> <i>ULBP2</i>, <i>RAET1G</i>, (ULBP5) stromal, immune, malignant cells (<i>N</i> = 5,902) from 18 treatment-naive patients with HNSC. <b>C,</b> Representative IHC images ULBP6/2/5 HNSC LUSC tumors (top)...
<div>Abstract<p>The landscape of cancer treatment has been transformed by immune checkpoint inhibitors; however, the failure to benefit a large number patients with underlined need identify promising targets for more effective interventions. In this study, we leverage 23andMe, Inc.’s large-scale human germline genetic and health database uncover previously unknown role UL16-binding protein 6 (ULBP6), high-affinity NK group 2D (NKG2D) ligand, in its promise as an immuno-oncology...
<p><i>RAET1L</i> (ULBP6) germline genetics. Regional GWAS plots of the three <i>RAET1L</i> variants: rs1543547, rs1555696, and rs61730071, identified in credible set that are significantly associated with (<b>A</b>) alopecia areata (<b>B</b>) basal cell carcinoma. The fourth variant, rs912565, is not either phenotype. <b>C,</b> variants, but showed significant (<i>P</i> < 5 × 10<sup>−8</sup>)...
<p>Supplementary Figure S2</p>
<p>Supplementary Figure S10</p>
<p>ULBP6 may be the most potent NKG2D ligand. <b>A,</b> Equilibrium dissociation constant K<sub>D</sub> for human NKG2DLs binding to as measured by a Biacore surface plasmon resonance assay. Data represent mean ± SD of three technical replicates per condition. ULBP4 is not shown, no was detected. <b>B,</b> IFNγ concentration supernatants IL-2/IL-15–primed PBMCs cocultured with COV644 cells and 0.05 200 nmol/L recombinant sULBP6-02 or sMICA 24 hours,...
<p>Neutralization of soluble ULBP6 by an anti-ULBP6/2/5 antibody promotes NK and CD8<sup>+</sup> T cell activation PBMC-mediated tumor killing. <b>A,</b> Crystal structure 23ME-01473 Fab in complex with human ULBP6-02. The extracellular domain ULBP6-02 is colored orange, glycan moieties from N-glycosylated asparagine are shown as sticks, the coding single-nucleotide polymorphism regions green spheres. surface representation light chain purple heavy dark purple....
<p>Binding affinity of anti-ULBP6/2/5 antibodies to human Fcγ receptors</p>