A5100742340- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Cancer-related molecular mechanisms research
- Molecular Sensors and Ion Detection
- RNA modifications and cancer
- Electrochemical Analysis and Applications
- Asymmetric Hydrogenation and Catalysis
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Advanced Biosensing Techniques and Applications
- Computational Physics and Python Applications
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Analytical Chemistry and Sensors
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Insect symbiosis and bacterial influences
- Cancer Mechanisms and Therapy
- Biosensors and Analytical Detection
- Water Systems and Optimization
- RNA Research and Splicing
- Skin and Cellular Biology Research
Beijing University of Chinese Medicine
2023-2025
ShanghaiTech University
2023-2025
Shaanxi Normal University
2024
Mohamed bin Zayed University of Artificial Intelligence
2023
Shandong University
2021-2022
Shandong Provincial Hospital
2021
Johns Hopkins University
2018
Central South University
2017-2018
Abstract The inherent chiral structures of DNA serve as attractive scaffolds to construct hybrid catalysts for valuable enantioselective transformations. Duplex and G‐quadruplex DNA‐based catalysis has made great progress, yet novel design strategies are highly demanding atomistic analysis active centers is still challenging. i‐motif could be finely tuned by different cytosine‐cytosine base pairs, providing a new platform catalysts. Herein, we found that human telomeric containing...
MicroRNAs (miRNAs) serve as diagnostic and prognostic biomarkers for a wide variety of cancers. Via the novel conjugates gold nanoparticle-coated magnetic microbeads (AuNP-MMBs) diblock oligonucleotide (ODN)-modified AuNPs, multiplexed electrochemical assay miRNAs was performed. The hybridization to target leads conformational change hairpin-structured ODN probes, attachment ODN-modified AuNPs achieved. By examining oxidation peak currents methylene blue (MB) ferrocene (Fc) moieties residing...
Abstract MicroRNAs (miRNAs) silence genes by binding to messenger RNAs, whereas long non-coding RNAs (lncRNAs) act as competitive endogenous (ceRNAs) that can relieve miRNA silencing effects and upregulate target gene expression. The ceRNA association between lncRNAs miRNAs has been a research hotspot due its medical importance, but it is challenging verify experimentally. In this paper, we propose novel deep learning scheme, i.e. sequence pre-training-based graph neural network (SPGNN),...
Polymer waste poses a significant challenge to humanity. In recent years, extensive efforts have been directed towards upcycling or degrading commercial polymers, as well developing sustainable alternatives. However, limitations such reliance on efficient collection systems and increased production costs persist. this study, we introduce strategy address the challenges by mechanically robust polymer networks that degrade in water within 30 days. Utilizing three low-cost starting...
Polymer waste poses a significant environmental challenge with current recycling strategies often hindered by inefficient collection systems, high production costs, and limited material recyclability. While extensive efforts have been directed towards upcycling or degrading commercial polymers, as well developing sustainable alternatives, many approaches remain constrained their reliance on harsh conditions, specialized catalysts, complex processing methods. In this study, we present novel...
Polymer waste poses a significant environmental challenge with current recycling strategies often hindered by inefficient collection systems, high production costs, and limited material recyclability. While extensive efforts have been directed towards upcycling or degrading commercial polymers, as well developing sustainable alternatives, many approaches remain constrained their reliance on harsh conditions, specialized catalysts, complex processing methods. In this study, we present novel...
Identification of gene variation is great importance for attaining information related to disease susceptibility. A highly sensitive and specific surface plasmon resonance (SPR) method quantification the apoE genotype discrimination was demonstrated. The complementary sequences with recognition sites GCGC bases upon hybridization preimmobilized biotinylated probes could be cleaved by restriction enzyme HhaI, while existence single-base mismatch (GTGC) prevented cleavage reaction. In both...
Abstract The inherent chiral structures of DNA serve as attractive scaffolds to construct hybrid catalysts for valuable enantioselective transformations. Duplex and G‐quadruplex DNA‐based catalysis has made great progress, yet novel design strategies are highly demanding atomistic analysis active centers is still challenging. i‐motif could be finely tuned by different cytosine‐cytosine base pairs, providing a new platform catalysts. Herein, we found that human telomeric containing...
Deep learning has fundamentally reshaped the landscape of artificial intelligence over past decade, enabling remarkable achievements across diverse domains. At heart these developments lie multi-layered neural network architectures that excel at automatic feature extraction, leading to significant improvements in machine tasks. To demystify advances and offer accessible guidance, we present a comprehensive overview most influential deep algorithms selected through broad-based survey field....
CRISPR-Cas9 systems have been widely harnessed for diverse genome editing applications because of their ease use and high efficiency. However, the large molecular sizes strict PAM requirements commonly used restrict broad in therapeutics. Here, we report basis a novel compact type II-A Eubacterium ventriosum system (EvCas9) with 1107 residues distinct 5′-NNGDGN-3′ (where D represents A, T, or G) specificity. We determine cryo-EM structure EvCas9 complex an sgRNA target DNA, revealing...
Abstract Background : Gastric cancer (GC) is a common malignant tumour of the digestive tract. prognosis GC patients still not optimistic. Apoptosis-related genes (ARGs) plays an important role in development, invasion, metastasis and drug resistance GC. Therefore, assessing interaction between ARGs may help identify specific biomarkers. Methods Differentially expressed (DEGs) were identified by integrating gene expression profiling analyses from The Cancer Genome Atlas (TCGA) cohort Gene...