A5033601658- Anesthesia and Neurotoxicity Research
- Xenotransplantation and immune response
- Immune cells in cancer
- Acute Kidney Injury Research
- Cardiac Fibrosis and Remodeling
- Conducting polymers and applications
- Cardiac Ischemia and Reperfusion
- Extracellular vesicles in disease
- Organ Transplantation Techniques and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Pancreatic function and diabetes
- Tissue Engineering and Regenerative Medicine
- Blood transfusion and management
- Cardiac electrophysiology and arrhythmias
- Nanowire Synthesis and Applications
- Natural Language Processing Techniques
- Sepsis Diagnosis and Treatment
- Reinforcement Learning in Robotics
- Animal Genetics and Reproduction
- Viral Infections and Immunology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Topic Modeling
- Cardiac Imaging and Diagnostics
- Chronic Kidney Disease and Diabetes
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Fu Wai Hospital
2025
State Key Laboratory of Cardiovascular Disease
2022-2025
Peking Union Medical College Hospital
2024-2025
Xenotransplantation offers a transformative solution to the global organ shortage crisis. However, survival of xenografts remains limited despite various proposed strategies. In this study, we present an endothelial cell protection strategy that extends graft through in situ construction biomimetic glycan-enriched nanofibers. These molecules specifically target integrin αvβ3 and form polysaccharide-structured nanofiber network on vascular surface. This protects cells without compromising...
Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common postoperative complication following cardiac surgery. Currently, there are no reliable methods for the early prediction of CSA-AKI in hospitalized patients. This study developed and evaluated diagnostic use metabolomics-based biomarkers patients with CSA-AKI. Methods Results A total 214 individuals (122 [AKI], 92 without AKI as controls) were enrolled this study. Plasma samples analyzed by liquid chromatography...
ABSTRACT Introduction Shortage of donor organs is one the greatest challenges cardiac transplantation. Xenotransplantation a potential way to solve contradiction imbalance and pigs are considered ideal sources. However, xenotransplantation still faces problem immune rejection at present. In order further understand molecular picture after xenotransplantation, develop immunosuppressive agents overcome rejection, we conducted proteomic analysis heterotopic pig‐to‐non‐human primate (NHP) animal...
Abstract Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects health of elderly population. To explore anti-aging strategies, we develop dynamic atlas covering 45 cell types human lungs, spanning from embryonic development to aging. We aim apply discoveries lung’s address aging-related issues. observe that both epithelial immune cells undergo process acquisition loss essential as they transition During aging, identify cellular...
The mechanism of cardiac reverse remodeling (CRR) mediated by the left ventricular assist device remains unclear. This study aims to identify specific cell type responsible for CRR and develop therapeutic target that promotes CRR.
Myocardial fibrosis is a pathological feature of doxorubicin-induced chronic cardiotoxicity that severely affects the prognosis oncology patients. However, specific cellular and molecular mediators driving cardiac fibrosis, relative impact different cell populations on remain unclear.This study aimed to explore mechanism myocardial find potential therapeutic targets. Single-cell RNA sequencing was used analyze transcriptome non-cardiomyocytes from normal in mouse model heart tissue.We...
Ischemia reperfusion injury (IRI), often related to surgical procedures, is one of the important causes acute kidney (AKI). To decipher dynamic process AKI caused by IRI (with prolonged ischemia phase), we performed single-cell RNA sequencing (scRNA-seq) clinically relevant murine model with different ischemic intervals. We discovered that Slc5a2hi proximal tubular cells were susceptible and highly expressed neutral amino acid transporter gene Slc6a19, which was dramatically decreased over...
The construction of a photocatalytic fuel cell based on piezoelectric-enhanced dual heterojunctions
Background: Myocardial fibrosis is a pathological feature of doxorubicin-induced chronic cardiotoxicity that severely affects the prognosis oncology patients. However, specific cellular and molecular mediators driving cardiac fibrosis, relative impact different cell populations on remain unclear.Objectives: The purpose this study to explore mechanism myocardial then find potential therapeutic targets.Methods: Single-cell RNA sequencing was used analyze transcriptome non-cardiomyocytes from...