A5053647242- COVID-19 Clinical Research Studies
- Plant Physiology and Cultivation Studies
- Garlic and Onion Studies
- Irrigation Practices and Water Management
- SARS-CoV-2 and COVID-19 Research
- Flowering Plant Growth and Cultivation
- Extracellular vesicles in disease
- Plant and animal studies
- Cardiomyopathy and Myosin Studies
- Long-Term Effects of COVID-19
- Cardiac Fibrosis and Remodeling
- Xenotransplantation and immune response
- Tissue Engineering and Regenerative Medicine
- Hospital Admissions and Outcomes
- Respiratory viral infections research
- Animal Genetics and Reproduction
- Cardiac Ischemia and Reperfusion
- Sleep and Work-Related Fatigue
- Atherosclerosis and Cardiovascular Diseases
- Phagocytosis and Immune Regulation
- Plant Reproductive Biology
- Cardiovascular Function and Risk Factors
- COVID-19 diagnosis using AI
- CRISPR and Genetic Engineering
- Immune cells in cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Kunming Medical University
2025
Fuwai Yunnan Cardiovascular Hospital
2025
Institute of Vegetables and Flowers
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
China Agricultural University
2024
Sanya University
2024
Fu Wai Hospital
2020-2022
University of Science and Technology
2020
Huanghe Science and Technology College
2020
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion remains elusive. Here, we show that classically activated M1 facilitate viral spread; however, alternatively M2 limit spread. utilize cellular softness efficiently take up SARS-CoV-2. Subsequently, invaded viruses over endo-lysosomal system escape. have a lower endosomal pH, favoring membrane fusion and allowing...
Silent hypoxia has emerged as a unique feature of coronavirus disease 2019 (COVID-19). In this study, we show that mucins are accumulated in the bronchoalveolar lavage fluid (BALF) COVID-19 patients and upregulated lungs severe respiratory syndrome 2 (SARS-CoV-2)-infected mice macaques. We find induction either interferon (IFN)-β or IFN-γ upon SARS-CoV-2 infection results activation aryl hydrocarbon receptor (AhR) signaling through an IDO-Kyn-dependent pathway, leading to transcriptional...
Exploring the cross-talk between immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy. Here, we show that ACE2-overexpressing A549 cell-derived microparticles (AO-MPs) are potential therapeutic agent against infection. Intranasally administered AO-MPs dexterously navigate anatomical biological features of lungs enter alveoli taken up by alveolar macrophages (AMs). Then, increase endosomal pH but decrease lysosomal in AMs, thus escorting bound from...
Inflammation is a key component in the development of abdominal aortic aneurysm (AAA), yet insights into roles immune cells and their interactions this process are limited.
ABSTRACT Introduction Shortage of donor organs is one the greatest challenges cardiac transplantation. Xenotransplantation a potential way to solve contradiction imbalance and pigs are considered ideal sources. However, xenotransplantation still faces problem immune rejection at present. In order further understand molecular picture after xenotransplantation, develop immunosuppressive agents overcome rejection, we conducted proteomic analysis heterotopic pig‐to‐non‐human primate (NHP) animal...
Polyethylene mulch film (PEM) is widely utilized in garlic cultivation, significantly enhancing yield. However, the prolonged use of this material leads to serious environmental issues that adversely affect soil health and plant growth. To promote adoption biodegradable (BDM) we investigate effects BDMs with thicknesses 0.006 mm, 0.008 0.010 mm on growth properties, comparing them commonly used PEM mm. The results indicated agronomic traits were improved under both compared no mulching,...
Low temperature is a major environmental constraint that limits crop productivity. In this investigation, 256 diverse garlic germplasm were tested for their cold tolerance at the seedling stage by being exposed to natural low-temperature stress −10∼-15 °C lowest night eight days. Several plant development indicators, as well index (CI), studied. The findings showed significant range of CI among these accessions, ranging from 16.98 70.38. All germplasms divided into five groups according and...
Giant lily (Cardiocrinum giganteum) is a perennial bulbiferous herb of Liliaceae and an endemic species in the eastern Himalayan region, which has become one new flower crops because its high ornamental value. The floral biology breeding characteristics C. giganteum were studied by monitoring characteristics, duration flowering, phenology, flowering behavior, outcrossing index (OCI), pollen-ovule ratio (P/O), pollen viability, stigma receptivity fruit sets under series pollination treatment....
Abstract Background: Arrhythmogenic cardiomyopathy (AC) is an inherited myocardial disease affecting the both ventricles. It shows large heterogeneity on its clinical, genetic, and pathological manifestations. The intercalated disc remodeling has been investigated in right ventricle (RV) of AC, however, ultrastructural features left (LV) among different genotypes remain unknown. Methods: ultrastructure characters ventricles from 24 AC who fulfilled international Task Force diagnostic 10...
Abstract Background The effect of time admission on clinical outcomes in patients with acute myocardial infarction (AMI) is still a matter debate. Purpose To investigate the association between off-hours and in-hospital mortality ST-elevation (STEMI) non-STEMI (NSTEMI). Methods We used two-stage, random sampling method to create nationally representative sample AMI 167 Chinese hospitals four years (2001, 2006, 2011, 2015). Off-hours were defined as 20:00–07:59 on-hours 08:00–19:59....