A5074855553- Nanoparticles: synthesis and applications
- Skin Protection and Aging
- DNA Repair Mechanisms
- Plant Genetic and Mutation Studies
- Air Quality and Health Impacts
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Gender Diversity and Inequality
- Light effects on plants
- Biosensors and Analytical Detection
- Occupational and environmental lung diseases
- Liver physiology and pathology
- Animal testing and alternatives
- Circadian rhythm and melatonin
- Photodynamic Therapy Research Studies
- Consumer Attitudes and Food Labeling
- Educational, Social, and Political Issues
- Bioinformatics and Genomic Networks
- Photoacoustic and Ultrasonic Imaging
- Anesthesia and Neurotoxicity Research
- Molecular Biology Techniques and Applications
- Evaluation and Performance Assessment
- Carcinogens and Genotoxicity Assessment
- Educational Research and Analysis
- Plant-Microbe Interactions and Immunity
Commonwealth Scientific and Industrial Research Organisation
2010-2021
Canberra (United Kingdom)
2020
Agriculture and Food
2016
Animal, Food and Health Sciences
2014
Deakin University
2005-2010
Nanotechnology is currently contributing substantially to the development of a broad range innovative technologies in agricultural, feed and food sector. To date, very little work has been done investigate efficacy antimicrobial nanoparticles against pathogens highest concern poultry industry. This study first report on effectiveness CuO Salmonella Ag Campylobacter. The aim this was assess vitro activity silver (Ag), zinc oxide (ZnO) copper (CuO) Campylobacter isolated from poultry. minimum...
Salmonellosis and campylobacteriosis are among the most frequently reported foodborne diseases worldwide. Commercial chicken meat has been identified as one of important food vehicles for Salmonella Campylobacter infection. Increased poultry consumption forced producers to explore methods increasing their production output, while maintaining affordability safety products. While forecast benefits nanotechnology have yet be fully realised, it potential application at many points along chain...
It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm explains toxicities of asbestos and other fibres on a continuum based length, aspect ratio biopersistence. Some types satisfy first two aspects but only recently their biopersistence begun be investigated. Biopersistence is complex requires in vivo testing analysis. However durability, chemical mimicking process dissolution using vitro treatment, closely related more readily determined. Here, we...
Previous studies have shown no, or very limited, skin penetration of metal oxide nanoparticles following topical application sunscreens, yet concerns remain about their safety compared to larger particles. Here, we assessed the comparative dermal absorption a traceable form Zn ((68)Zn) from (68)ZnO nano-sized and particles in sunscreens. Sunscreens were applied backs virgin pregnant hairless mice over four days. Control groups received applications sunscreen formulation containing no ZnO...
Abstract Background Batch effects are a persistent and pervasive form of measurement noise which undermine the scientific utility high-throughput genomic datasets. At their most benign, they reduce power statistical tests resulting in actual going unidentified. worst, constitute confounds render datasets useless. Attempting to remove batch will result some biologically meaningful component (i.e. signal) being lost. We present benchmark novel technique, called Harman . maximises removal with...
The application of sunscreen is a critical component sun-safe strategy, however the possibility unexpected, adverse outcomes resulting from long-term use sunscreens containing nanoparticles titanium dioxide (TiO2) and zinc oxide (ZnO) has not yet been examined. Here, immune-competent hairless mice were exposed over 36-week period to weekly topical applications ZnO or TiO2, no metal nanoparticles, with without subsequent exposure ultraviolet radiation (UVR). Control groups received...
Summary Upon blockage of chromosomal replication by DNA lesions, Y‐family polymerases interact with monoubiquitylated proliferating cell nuclear antigen (PCNA) to catalyse translesion synthesis (TLS) and restore fork progression. Here, we assessed the roles Arabidopsis thaliana POLH , which encodes a homologue polymerase η (Polη), PCNA1 PCNA2 in TLS‐mediated UV resistance. A T‐DNA insertion sensitized growth roots whole plants radiation, indicating that AtPolη contributes alone did not...
Inhaled nanoparticles have been reported in some instances to translocate from the nostril olfactory bulb exposed rats. In close proximity is mucosa, within which resides a niche of multipotent cells. Cells isolated this area may provide relevant vitro system investigate potential effects workplace exposure inhaled zinc oxide nanoparticles. Four types commercially-available (ZnO) nanoparticles, two coated and uncoated, were examined for their on primary human cells cultured mucosa. Human...
. 1) Background: Intersectionality contests that individuals have multiple characteristics in their identity cannot be siloed or deemed exclusive to each other. Understanding and utilising an intersectional lens organisations can increase inclusion of organisational performance. An educational package known as the Walk (IW) was developed by authors, piloted, evaluated order break down commonly held descriptors diversity silos fragments inclusion, understand how various compound disadvantage....
Lipid droplets (LDs) are the main storage organelles for triglycerides. Elucidation of lipid accumulation mechanisms and metabolism essential to understand obesity associated diseases. Adipogenesis has been well studied in murine 3T3-L1 human Simpson-Golabi-Behmel syndrome (SGBS) preadipocyte cell lines. However, most techniques measuring LD either not quantitative or can be destructive samples. Here, we describe a novel, label-free quantification technique (LipiD-QuanT) monitor dynamics...
Summary Eukaryotic general transcription factor (TF) IIH is composed of 10 proteins, seven which are also required for nucleotide excision repair (NER) UV radiation‐induced DNA damage in human cells and yeast. Plant homologues the TFIIH subunits XPB XPD that function NER have been isolated but none has shown to operate transcription. Here we address capabilities Arabidopsis thaliana AtGTF2H2 AtXPD, essential interacting human/yeast components p44/Ssl1 XPD/Rad3, respectively. Expression or...
Coatings applied to the surfaces of zinc oxide (ZnO) nanoparticles have been shown decrease capacity uncoated generate free radicals, as well reduce their solubility, and may be utilized in safetyby-design approaches ZnO nanoparticle toxicity.The liver is a target organ for nanoparticles, or ionic released from whether route entry by dermal absorption, ingestion, injection inhalation.Liver injury fibrosis demonstrated vivo response treatment, cell has also vitro using immortalized hepatocyte...
Arsenic (As) induces DNA-damaging reactive oxygen species. Most oxidative DNA damage is countered by base excision repair (BER), the capacity for which may be reduced in older animals. We examined whether age and consumption of As lactational milk or drinking water influences BER gene transcript levels mice. Lactating mothers 24-week-old mice were exposed (24 h 2 weeks) to (2 50 p.p.m.) water. Lung tissue was harvested from adults, neonates (initially 1 week old) feeding lactating untreated...
Summary Plasmonic resonances of metal‐based nanoparticles are increasingly used for ultrasensitive imaging assays. In this context, the Cytoviva TM microscopy platform has greatly gained in popularity. essence, is an optimized dark field microscope that permits detection particles down to a few nanometers size. A significant limitation up now been it only provided single plane imaging. The datasets produced by technique therefore show partial view sample – not ideally suited analysis. Here...
Contains additional information and discussion on gPCA (Reese et al., 2013). Table S1. Demonstrates the inverse proportionality between p-value associated â deltaâ score, reflecting unadjusted relative magnitude of batch effects The table shows scores for all three datasets. Figure an Illustration to further help interpret vs preserved data variance plots. (DOCX 60 kb)