A5026337764- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- Coral and Marine Ecosystems Studies
- Knee injuries and reconstruction techniques
- RNA and protein synthesis mechanisms
- Exercise and Physiological Responses
- Parasite Biology and Host Interactions
- Mesenchymal stem cell research
- RNA Research and Splicing
- Nutrition and Health in Aging
- Cancer-related gene regulation
- Crustacean biology and ecology
- Immunotherapy and Immune Responses
Dynamique du noyau
2022-2023
Institut Curie
2022-2023
Sorbonne Université
2023
Université Paris Sciences et Lettres
2023
Centre National de la Recherche Scientifique
2023
University of Geneva
2018-2021
University of Warsaw
2016
University of Chicago
2016
William & Mary
2013
inhibition by 3 0 splice site m 6 A is conserved in mammals
The ability to replicate and pass information descendants is a fundamental requirement for life. In addition the DNA-based genetic information, modifications of DNA or DNA-associated proteins can create patterns heritable gene regulation. Such epigenetic inheritance allows adaptation without mutation, but its limits regulation are incompletely understood. Here we developed C. elegans system study transgenerational H3K27me3, conserved histone posttranslational modification associated with...
Abstract Histone H3.3, a major variant of canonical histone H3, is highly conserved and essential for viability or fertility in most lineages. In Caenorhabditis elegans, H3.3 expressed from five genes. Here, Delaney... Replication-independent histones replace nucleosomes act as important regulators chromatin function. H3 that remarkably across taxa distinguished by just four key amino acids. Most genomes contain two more genes expressing complete loss the protein usually causes sterility...
Skeletal muscles are characterized by their unique ability to regenerate. Injury of a so-called fast-twitch muscle, extensor digitorum longus (EDL), results in efficient regeneration and reconstruction the functional tissue. In contrast, slow-twitch muscle (soleus) fails properly reconstruct develops fibrosis. This study focuses on soleus EDL associated inflammation.We determined differences activity neutrophils M1 M2 macrophages using flow cytometry levels proinflammatory cytokines Western...
Abstract Substitution of lysine 27 with methionine in histone H3.3 is a recently discovered driver mutation pediatric high-grade gliomas. Mutant cells show decreased levels and altered distribution H3K27 trimethylation (H3K27me3). How these chromatin changes are established genome-wide lead to tumorigenesis remains unclear. Here we that H3.3K27M-mediated alterations H3K27me3 result ectopic DNA replication cell cycle progression germ Caenorhabditis elegans . By genetically inducing the...
Centromere protein A (CENP-A) is a histone H3 variant that defines centromeric chromatin and essential for centromere function. In most eukaryotes, CENP-A-containing epigenetically maintained, identity inherited from one cell cycle to the next. germ line of holocentric nematode Caenorhabditis elegans , this inheritance disrupted. CENP-A removed at mitosis-to-meiosis transition reestablished on during diplotene meiosis I. Here, we show N-terminal tail required de novo establishment...
In mammalian cells under oxidative stress, the methionyl-tRNA synthetase (MetRS) misacylates noncognate tRNAs at frequencies as high 10% distributed among up to 28 tRNA species. Instead of being detrimental for cell, misincorporation methionine residues in proteome reduces risk damage proteins, which aids stress response. microarrays have been essential detection full pattern misacylated tRNAs, but limited capacity investigate misacylation and mistranslation mechanisms live cells. Here we...
Abstract Centromere protein A (CENP-A) is a histone H3 variant that defines centromeric chromatin and essential for centromere function. In most eukaryotes CENP-A-containing epigenetically maintained, identity inherited from one cell cycle to the next. germ line of holocentric nematode Caenorhabditis elegans , this inheritance disrupted. CENP-A removed at mitosis-to-meiosis transition established de novo on during diplotene meiosis I. Here we show N-terminal tail required establishment...
Abstract Substitution of lysine 27 with methionine in histone H3.3 is a recently discovered driver mutation pediatric high-grade gliomas. Mutant tumor cells show decreased levels and altered distribution H3K27me3. How these chromatin changes are established genome-wide lead to tumorigenesis only specific tissues remains unclear. Here we that H3.3K27M-mediated alterations H3K27me3 result ectopic DNA replication cell cycle progression germ Caenorhabditis elegans . By genetically inducing the...