A5041093388- Seaweed-derived Bioactive Compounds
- Catalytic C–H Functionalization Methods
- Algal biology and biofuel production
- Synthesis and biological activity
- Catalytic Cross-Coupling Reactions
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Computational Drug Discovery Methods
- Inflammatory mediators and NSAID effects
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Metal complexes synthesis and properties
- Radical Photochemical Reactions
- Marine Sponges and Natural Products
- Marine and coastal plant biology
- Electrohydrodynamics and Fluid Dynamics
- Nanoplatforms for cancer theranostics
- CO2 Reduction Techniques and Catalysts
- Asymmetric Hydrogenation and Catalysis
- Cancer therapeutics and mechanisms
- Microwave-Assisted Synthesis and Applications
- Artificial Intelligence in Healthcare
- Sulfur-Based Synthesis Techniques
- Synthesis of β-Lactam Compounds
Swami Rama Himalayan University
2025
Graphic Era University
2021-2024
Hindu College of Pharmacy
2021
National Institute of Pharmaceutical Education and Research
2014-2019
Galgotias University
2018-2019
The 2-(2-arylphenyl)benzoxazole moiety has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). 2-(2-arylphenyl)benzoxazoles 3a-m have synthesized by Suzuki reaction of 2-(2-bromophenyl)benzoxazole. Further synthetic manipulation 3f 3i led 3o 3n, respectively. compounds 3g, selectively inhibited COX-2 with selectivity index 3n much better than that NSAID celecoxib. in vivo anti-inflammatory potency 3g is comparable celecoxib nonselective diclofenac at two...
A novel strategy for direct aryl hydroxylation via Pd-catalysed Csp(2)-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles various acyclic functionalities versatile directing groups.
Abstract: Carrageenan (CG) a sulfated polysaccharide (SP) is produced using variety of seaweeds from the Rhodophyceae family. This type seaweed available in areas, like Atlantic Ocean close to Great Britain, Europe, and North America. has been permitted for use as food items with European additive E-number E407. widely used derived red known its various applications chemical, biological, pharmaceutical fields. It delves into versatile across sub spanning industry. A significant emphasis...
Abstract The development of stable carrageenan nanoparticles connected to the sulfate functional group and barium ion for use selectively targeting cancer cell imaging contrast help with diagnosis (tracing/imaging) is concern present research. This study provides an overview substitution chemistry, highlighting role ions how they affect applicability carrageenan. characteristic sulfate, which widely used as radiopaque provide diagnostic radiographic examinations in gastrointestinal mucosa,...
The palladium–nickel binary nanocluster is reported as a new catalyst system for Suzuki–Miyaura cross-coupling of ortho-heterocycle-tethered sterically hindered aryl bromides. inferior results obtained with the Pd/Ni salts/complexes or individual nanoparticles reveal cooperative catalytic effect Pd and Ni in Pd–Ni nanocluster. broad substrate scope respect to variation 2-arylbenzoxazole moiety boronic acids, which offers means diversity generation recyclability, marks distinct advantage.
Cascade<italic>N</italic>-aroylmethylation–reduction–condensation process as novel strategy of “all water chemistry” for first generalized regioselective synthesis 2-aryl quinoxalines.
Abstract Iota carrageenan is characterized as a hydrocolloid, with the limitations of hygroscopicity and hydrophilicity. Here, each these factors addressed to enhance stability, hydrophobicity through protection highly reactive primary alcohol formation stable, improved hydrophobic, conductive gel for loading lipophilic drugs. The functionalized polymer evaluated microscopic scanning electron microscopy (SEM) image compounds, which confirm confined nature polymer. Moreover, values changed...
Ni–Pd binary nanoclusters are reported for the activation of C–O bond Suzuki–Miyaura cross-coupling bioactive heterocycle-tethered sterically hindered aryl carbonates with boronic acids. The reaction does not take place in presence either Pd or Ni salts/complexes individual nanoparticles, indicating ensembling cooperativity between and nanoparticles activating bond.
Background: The quinoline scaffold has been an attraction due to its pharmacological activities such as anti-HIV, anti-neoplastic, anti-asthmatic, anti-tuberculotic, anti-fungal, and anti-bacterial. Objective: designed quinoline-3-carboxylate derivatives were synthesized through a two-step reaction evaluated for antiproliferative activity against MCF-7 K562 cell lines. Methods: Synthesized compounds characterized by modern analytical techniques like NMR, 2DNMR, mass, IR. Moreover, the purity...
Abstract Polymers, in their grafted and derivatized forms, are frequently used medical research due to unique properties as diagnostic, targeted, sustained, regulated carriers. The method of iota carrageenan nanogel has been developed this invention. is based on solubility, which was first investigated using the solvent screening technique. de-solvating agent then reduce particle size produce gel nano form, moreover, viscosity other physical were evaluated. Furthermore, it compared basic...
Abstract The paradigm of cancer treatment has been shifting from traditional approaches to metal-based therapies; however, achieving effective and targeted treatments remains a significant challenge. journey drugs began with the serendipitous discovery cisplatin, which paved way for development various platinum derivatives. Additionally, other metals, such as ruthenium (Ru), nickel (Ni), zinc (Zn), copper (Cu), have explored their therapeutic potential. Among these, ruthenium-based complexes...
Abstract This review highlights multicomponent reactions (MCRs) and their utilization in carbohydrate chemistry, where the anomeric center remains a concerning point maintaining selectivity is major challenge. Successful examples included involve synthesis of multifunctional carbohydrates with enhanced inherent physicochemical biological properties. compiles presents importance MCR which parent structure modified intact. explores various types MCRs applied to carbohydrates, highlighting...
Background: Lung cancer is one of the most widespread malignancies among all types cancers. There uncertainty in its treatment because selectivity. The investigation aimed to enhance therapeutic efficacy through targeted improvements drug selectivity and reduced toxicity by analyzing well-accepted cyclooxygenase (COX)-2, which an enzyme target a known for anti-inflammatory antitumor agents. Objective: objective present research was identify suitable counterpart celecoxib, would produce...
Background: The 2-styrylquinoline-3-carboxylate derivatives have been reported as antiproliferative agents. Objective: aim of the study was to enhance selectivity drug cancer cells. change in pKa value can be boost point selectivity. will concentration cells and reduce absorption non-cancerous Methods: designed hydrolysis ester group obtained through method physiological properties, which correlated with silico vitro studies. compounds were characterized important analytical techniques,...