A5061467036- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Erythropoietin and Anemia Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac and Coronary Surgery Techniques
- Workplace Violence and Bullying
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Management, Economics, and Public Policy
- Atrial Fibrillation Management and Outcomes
- Global Health Workforce Issues
- Healthcare Facilities Design and Sustainability
- Disaster Response and Management
- Neutropenia and Cancer Infections
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Genetic and rare skin diseases.
- Antifungal resistance and susceptibility
- Ethics in medical practice
- Platelet Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- RNA regulation and disease
- Tuberous Sclerosis Complex Research
Barts Health NHS Trust
2015-2023
Guy's and St Thomas' NHS Foundation Trust
2022
British Heart Foundation
2016-2022
King's College London
2016-2022
University College Hospital
2014
University College London
2014
William Harvey Research Institute
2011
Queen Mary University of London
2011
Queen's Hospital
2011
Chelmsford and Essex Hospital
2011
Platelet reactivity testing is important for the diagnosis of bleeding disorders, and increasingly to optimise anti-platelet therapy. Traditional light transmission aggregometry considered gold standard, whilst 96-well plate aggregometry, founded on similar principles, provides a higher throughput screening method. Despite widespread use both, methodologies outputs vary widely between laboratories. We report methodological approach towards providing standardised optical detection platelet...
Aims Iron deficiency (ID) is prevalent and adverse in chronic heart failure (CHF) but few human studies have explored the myocardial mechanism(s) that potentially underlie this adversity. Because mitochondrial oxidative phosphorylation (OXPHOS) provides over 90% of hearts adenosine triphosphate (ATP), iron critical for OXPHOS, we hypothesized patients with CHF ID would harbour greater cardiac energetic impairments than without ID. Methods results Phosphorus magnetic resonance spectroscopy...
Background The Sant'ANna TIrofiban Safety study (SANTISS) is an open-label investigator-initiated single-centre registry launched to assess the combination of bleeding and access site in-hospital complications (primary end-point) in patients undergoing percutaneous coronary intervention (PCI) by femoral approach only. Methods We compared who were on oral single antiaggregating drug (AAD) received, just prior PCI, high-dose tirofiban a second antiplatelet agent (triple AAD: group 1, n = 970)...
In the literature, several malformations of cortical development have been described as additional lesions in tuberous sclerosis complex. Among these lesions, a very large focal dysplasia has peculiar magnetic resonance imaging features: signal abnormality that extends radially inward toward lateral ventricle from pachygyric surface plus homogeneous clinical picture. Affected patients early-onset drug-resistant epilepsy and severe developmental delay. We describe clinical, genetic,...
AbstractIn patients undergoing bone marrow transplantation cryptococcosis is rarely encountered. We report a fatal case of Cryptococcus meningitis in 12-year-old girl with acute lymphoblastic leukemia (ALL) second remission who had transplant from human leukocyte antigen (HLA)-identical unrelated donor. The conditioning regimen was thiotepa, cyclophosphamide, and total body irradiation (TBI); graft-versus-host disease (GVHD) prophylaxis consisted cyclosporin A, methotrexate, antilymphocyte...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to reduce cardiovascular rehospitalisation in heart failure with reduced ejection fraction (HFrEF) patients. However, it is unknown whether initiating SGLT2i during an inpatient stay for a HFrEF exacerbation results better outcomes versus initiation post-discharge cohort of diabetic and non-diabetic This study compares rehospitalisation, specific death, all-cause death between patients initiated on as post-discharge. A...
There is some controversy as to whether tirofiban or eptifibatide, two small anti-aggregating drugs (AAD), may reduce the incidence of composite ischemic events within one year in patients undergoing percutaneous coronary intervention (PCI) real clinical world.We compared consecutive on oral double AAD (with clopidogrel and aspirin) who underwent PCI (n=207) were single received a second AAD, just prior PCI, either high-dose double-bolus eptifibatide (double plus molecules group, n=666). The...
Background: Plasma volume (PV) expansion hallmarks worsening chronic heart failure (CHF) but no non-invasive means of quantifying status exists. Because weight and hematocrit are intimately related to PV, we derived an index relative PV (PVS) using validated equations based on these simple indices. We tested the validity prognostic utility our in a logical sequence analyses. Methods: First, correlated current measured 125 Iodine-human serum albumin calculated values ([1-hematocrit] x [a + (b...
Opportunities to participate in leadership and management with protected time can be limited for clinical trainees. The aim of this fellowship was gain experience gold standard healthcare by becoming part multidisciplinary teams working deliver transformational change the National Health Service (NHS).
Background The first MRI conditional pacemaker was introduced in 2008. Though, they represent the minority of all devices implanted, their use has increased. Similarly, CMR imaging UK increased from just over 20,000 studies 2008 to nearly 40,000 scans 2010. However, there is limited data describing frequency, safety and diagnostic quality patients with MR devices. Our aim describe device scanning our clinical practice identify reasons why pacemakers were selected.
Background: Whilst pre-operative anemia escalates morbidity and mortality after coronary artery bypass grafting (CABG), it is unclear whether its different etiologies confer magnitudes of risk. Because iron quantitatively the most important biocatalyst in human physiology, we hypothesized that deficiency (ID) (IDA) might greatest hazard. Additionally, supposed ID even absence be detrimental. Methods: We analysed hospital outcomes 1910 CABG patients (mean [±SD] age 67±10 years, EuroSCORE...
Red cell distribution width (RDW), an index of the variation in red volume, is a surrogate many aberrations (iron deficiency, inflammation, malnutrition and oxidative stress) that could impair early late outcomes after aortic valve replacement (AVR). Whilst increase In RDW powerfully predicts morbidity mortality heart failure PCI patients, its prognostic relevance AVR cohorts unknown. Methods: We analysed relation changes over time to 1177 patients (mean [±SD] age 68±13 years, 14.1±1.6%,...
Objective: The aim of this study was to investigate whether potassium channel blocking agents were able modulate positive inotropic effect levosimendan in isolated human atrial trabecular muscles or not. Material and Methods: right appendage samples (1 cm2, 500-1000 mg) removed immersed preoxygenated modified Tyrodes solution. Preparations used the concentration-effect relation (10-9 10-4 M) alone presence Ca2+-dependent blocker 4-aminopyridine (4-AP: 500 ?M), ATP-dependent glibenclamide ?M)...