To evaluate the efficacy of transepithelial collagen crosslinking (CXL) in patients with bilateral progressive keratoconus.Outpatient ophthalmic clinic.Cohort study.Patients a history keratoconus were recruited. The worst eye was treated CXL, while fellow left untreated as control. Transepithelial CXL performed by applying an enhanced riboflavin solution (riboflavin 0.1%, dextrane T500 trometamol [Tris-hydroxymethyl aminomethane] and EDTA [ethylenediaminetetraacetic] sodium salt) on intact...

<h3>Aims</h3> A blind, randomised, prospective, bilateral study to investigate the efficacy of riboflavin/ultraviolet corneal collagen cross-linkage halt progression keratoconus. <h3>Methods</h3> 24 patients with early/moderate keratoconus recent were recruited. One eye was randomly assigned undergo following epithelial removal riboflavin 0.1% and ultraviolet (370 nm at 3 mW/cm²). The other remained untreated as a control. follow-up 18 months in 22 patients. <h3>Results</h3> At...

To determine long-term efficacy of riboflavin/ultraviolet A corneal cross-linking (CXL).Thirty patients (30 eyes) who had undergone CXL following epithelial removal 4-6 years previously were examined.At 1-year mean, spherical equivalent error (SEQ) increased by +0.72 dioptres (D) (p<0.002), corrected distance visual acuity (CDVA) improved (p<0.005), mean simulated keratometry (Sim K) reduced 0.27D (p<0.04), cone apex power (CAP) 0.4D (p<0.02), and secondary astigmatism (p<0.03) compared with...

ABSTRACT BACKGROUND: Photorefractive keratectomy causee marked alteration to anterior corneal topography, and is likely induce major changes the optical aberrations of eye. METHODS: Six diopters (D) myopia correction was attempted on one eye 50 patients, randomly allocated three different treatments: 5-mm or 6-mm single ablation zone, a double (multizone; -5.00 D over 4.6 mm -1.00 6 mm). Topographic data used estimate aberration coefficients. These were compared for effect before 1 year...

<h3>Objective:</h3> To determine the effects of ablation diameter on outcome excimer laser photorefractive keratectomy. <h3>Design:</h3> Eighty patients were randomized to either a 5.00-mm or 6.00-mm treatment group and within these groups underwent −3.00-diopter (D) ora −6.00-D correction based their preoperative refraction. A Summit Omnimed was used throughout study. <h3>Results:</h3> In eyes treated with 6.00-mm-diameter ablation, initial hyperopic shift reduced, significant differences...

Aims: To compare trabeculectomy with viscocanalostomy for the control of intraocular pressure (IOP) in open angle glaucoma (OAG) uncontrolled by medical therapy. Methods: 48 patients (50 eyes) OAG were randomised to either (25 or a technique eyes). Preoperatively, eyes graded terms risk factors drainage failure. Those undergoing given intraoperative antimetabolites (5-fluorouracil 25 mg/ml (5-FU), mitomycin C (MMC) 0.2 and 0.4 mg/ml) according standard protocol. Antimetabolites not used...

PURPOSE: To evaluate the importance of complete epithelial removal before riboflavin–ultraviolet-A (UVA) corneal collagen crosslinking therapy. SETTING: School Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom. METHODS: Riboflavin eyedrops were applied at 5-minute intervals for 35 minutes to anterior surface 36 porcine eyes (12 with no trauma but treated tetracaine eyedrops, 12 superficial an intact basal epithelium, a fully removed epithelium). The 6...

To compare the results of manual limbal relaxing incisions (LRIs) performed during conventional phacoemulsification surgery with those nonpenetrating femtosecond laser arcuate keratotomies laser-assisted cataract to manage corneal astigmatism.Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.Randomized case-controlled trial.This was a secondary outcome randomized controlled trial comparing 400 patients treated or surgery. All astigmatism greater than 0.9 diopter (D) were...

Purpose To compare the clinical results of conventional phacoemulsification surgery (CPS) with femtosecond laser–assisted cataract surgery. Setting Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom. Design Single-center prospective randomized interventional case-controlled trial. Methods Patients undergoing were to receive either CPS or The was performed a laser (Lensx), and all operations gravity-fluidics torsional machine (Infiniti). visual acuity, refraction, central corneal...

ABSTRACT BACKGROUND: To date, there has been no systematic study of the effects ablation zone diameter on outcome photorefractive keratectomy. address these issues, we examined a series eyes with bilateral corrections using different-sized zones. METHODS: Thirty-three patients underwent keratectomy (Summit Excimed UV200, Waltham, Mass) identical dioptric in both eyes, except first had 4.00-millimeter and second 5.00-millimeter Identical postoperative eyedrop regimens were used each subject...

Purpose: To compare stromal riboflavin absorption after 20% alcohol application and partial or complete epithelial removal by analyzing light transmission properties of porcine corneas riboflavin/ultraviolet A (UVA) corneal collagen cross-linking. Methods: Riboflavin 0.13% eye drops were applied to 18 eyes (6 in which solution had been for 40 seconds, 6 with a grid pattern full-thickness trauma, the central epithelium fully removed) at 5-minute intervals 35 minutes. In all eyes, surface was...

Purpose To examine the effect of standard and accelerated corneal collagen crosslinking (CXL) on enzymatic resistance. Setting School Optometry Vision Sciences, Cardiff University, Cardiff, United Kingdom. Design Experimental study. Methods Sixty-six enucleated porcine eyes (with epithelium removed) were assigned to 6 groups. Group 1 remained untreated, group 2 received dextran eyedrops, groups 3 riboflavin/dextran eyedrops. 4 had CXL (3 mW/cm2 ultraviolet-A for 30 minutes), whereas 5 (9 10...