A5067000713- Supramolecular Chemistry and Complexes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Molecular Sensors and Ion Detection
- Advanced NMR Techniques and Applications
- Radioactive element chemistry and processing
- Porphyrin and Phthalocyanine Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Axial and Atropisomeric Chirality Synthesis
- Molecular spectroscopy and chirality
- Carbon dioxide utilization in catalysis
- Synthesis and Properties of Aromatic Compounds
Tallinn University of Technology
2015-2020
Chiral (<italic>all-R</italic>)-cyclohexanohemicucurbit[8]uril binds anions in a 1 : ratio pure methanol like molecular Pac-Man™ with remarkable selectivity based on the size, shape and charge distribution of anion.
Enantiomerically pure cyclohexylhemicucurbit[8]uril (cycHC[8]), possessing a barrel-shaped cavity, has been prepared in high yield on gram scale from either (R,R,N,N')-cyclohex-1,2-diylurea and formaldehyde or cycHC[6]. In case, dynamic covalent library is first generated which the desired cycHC can be amplified using suitable anion template.
The first inverted hemicucurbituril is synthesized in insufficient amount of template during oligomerisation and through its early precipitation.
Cyclic and linear oligomers of hemicucurbiturils have large difference in UV absorbance.
Amplification of a thermodynamically unfavoured macrocyclic product through the directed shift equilibrium between dynamic covalent chemistry library members is difficult to achieve. We show for first time that during condensation formaldehyde and cis - N,N' -cyclohexa-1,2-diylurea formation inverted-cis -cyclohexanohemicucurbit[6]uril ( i-cis -cycHC[6]) can be induced at expense favoured -cycHC[6]). The i-cis- cycHC[6] enhanced in low concentration templating chloride anion suppressed...
Amplification of a thermodynamically unfavoured macrocyclic product through the directed shift equilibrium between dynamic covalent chemistry library members is difficult to achieve. We show for first time that during condensation formaldehyde and <i>cis</i>-<i>N,N'</i>-cyclohexa-1,2-diylurea formation <i>inverted-cis</i>-cyclohexanohemicucurbit[6]uril (<i>i-cis</i>-cycHC[6]) can be induced at expense favoured...