Незважаючи на успіхи щодо подовження тривалості функціонування трансплантованої нирки, вона складає, у середньому, лише 10-12 років. При цьому тривалість нирки прогресивно знижується вже після першого року трансплантації. Прогресуюче зниження функціональної здатності обумовлюється двома основними групами причин: неімуноопосередкованими та імуноопосередкованими. Відстрочена функція трансплантата (ВФТ) є кількісним і якісним інтегральним проявом як імуноопосередкованих так...

Abstract Peritoneal dialysis (PD) stands as an important modality among kidney replacement therapies for end-stage disease, offering patients remarkable flexibility and autonomy. Despite its widespread use, challenges such glucose-related complications, peritoneal membrane fibrosis, declining renal function, cardiovascular risks persist, necessitating innovative therapeutic approaches. Sodium–glucose cotransporter 2 (SGLT2) inhibitors, originally developed treating type diabetes mellitus,...

Abstract Long COVID, characterized by persistent symptoms following acute infection, poses a significant health challenge, particularly for patients with pre-existing chronic conditions such as hypertension. We hypothesized that an increase in the production of interleukins (IL)-6 and IL-17 could serve potential mechanism linking uncontrolled blood pressure (BP) to occurrence long-term COVID sequelae undergoing hemodialysis (HD). This cross-sectional study examined serum IL-6 levels 80 HD,...

Introduction The health and survival of patients living with kidney failure have been threatened by the ongoing conflict in Ukraine. Commencing February 24, 2022, Russian invasion scaled up to become largest most ferocious military assault Europe since World War II. war triggered forced migration, leading displacement >13.3 million Ukrainians, equivalent 32% nation's 44.1 citizens. This figure included 5.6 refugees (1) who fled European nations 7.7 internally displaced persons (2) inside...

Background: Nutritional status’s role in long COVID is evident the general population, yet unexplored patients undergoing hemodialysis (HD), posing a research gap. We hypothesized that pre-infection undernutrition HD might impact persistence by accelerating oxidative stress. The present study aimed to investigate association between nutritional status, stress, and one-year-long patients. Methods: This prospective observational cohort enrolled 115 with confirmed COVID-19. status was assessed...

pathophysiology of long-COVID sequelae in the general population SARS-CoV-2-infected patients has been shown to be strongly influenced by oxidative stress. However, potential role stress development hemodialysis (HD) never investigated.
 The present study aimed evaluate status HD 3.5 months after SARS-CoV-2 infection relation presence and severity acute phase COVID-19.
 Methods. This cross-sectional cohort included 63 with a median age 55 (43-62.5) years dialysis vintage 42 (25-73)...

It was hypothesized that oxalate might be strongly involved in atherogenesis and the inflammatory pathway could result an increased risk of cardiovascular disease (CVD) end-stage renal (ESRD) patients. Therefore, this study aimed to address two primary research questions: characterize lipid profile pattern pro-inflammatory cytokines according plasma oxalic acid (POx) concentration ESRD patients; evaluate potential role elevated POx development CVD risk.A total 73 participants were enrolled...

an excess of free radicals accompanies the development renal pathologies and causes numerous concomitant complications syndromes.the most common these are cardiometabolic syndromes in patients with chronic kidney disease.therefore, purpose study was to determine activity paraoxonase-1 myeloperoxidase, which associated indicators high-density lipoproteins content oxidative stress blood stage disease.the enzymes, thiobarbiturate-active products concentration transferrin, ceruloplasmin, thiol...

A large body of research has investigated the effects pro-atherogenic lipid profile on cardiovascular diseases (CVD) in peritoneal dialysis (PD) patients. However, there is a general lack association between atherogenic dyslipidemia and PD technique survival.The study aimed to define survival.It was prospective single-centre observational involving 40 outpatients continuous ambulatory treatment for more than 3 months 2010 2016 single centre Ukraine. There were 27 males 13 females. The mean...

<br><b>Introduction:</b> Increased oxidative stress is suggested as one of the possible mechanisms structural and functional damage to peritoneal membrane in dialysis patients. But there are few available data on association with adequacy technique survival. The present study was undertaken investigate biomarkers <b>Methods:</b> This prospective single-center observational conducted between January 2010 May 2015. Adequacy dialysis, malondialdehyde levels serum erythrocytes (as an indicator...

OPINION article Front. Pharmacol., 28 May 2021 | https://doi.org/10.3389/fphar.2021.692429

Introduction and aim. Long-term outcomes of COVID-19 pose a global challenge, particularly impacting individuals with un derlying health conditions, including those who have undergone hemodialysis (HD). The study aimed to investigate the rela tionship between preexisting dialysis dose, measured by single pool Kt/V (spKt/V), long-term in patients undergoing HD. Material methods. Demographic, clinical, laboratory parameters following recovery, out comes, presence sequelae, hospitalization,...

Abstract. A decline in high-density lipoprotein (HDL) has been observed the general population of COVID-19 infected patients. However, little research devoted to this topic hemodialysis (HD) patients and there is a lack data on association between baseline HDL level outcomes HD The present study aimed assess levels risk developing severe infection patients.&#x0D; Methods. total 428 aged 55 (44-64) years dialysis vintage 44 (21-76.6) months were enrolled multicenter propensity-score matched...

Background and Objectives: The present study aims to investigate the association between gut microbiota's oxalate-degrading activity (ODA) risk of developing cardiovascular disease (CVD) over a three-year follow-up period in cohort patients undergoing kidney replacement therapy (KRT). Additionally, various factors were examined gain insight into potential mechanisms underlying ODA-CVD link. Materials Methods: A 32 KRT 18 healthy volunteers was enrolled this prospective observational pilot...

Background: Nutritional status and oxidative stress have been implicated in the pathogenesis persistence of long COVID, but data patients undergoing hemodialysis (HD) are limited. The present study aimed to investigate association between pre-infection nutritional status, stress, one-year COVID HD patients. Methods: This prospective observational cohort enrolled 115 with confirmed COVID-19. was assessed using Controlling Status (CONUT) score twice: before infection three months...

Background: Long-term consequences of COVID-19, known as long COVID, present distinctive hurdles for patients receiving hemodialysis treatment. Reduced levels high-density lipoprotein (HDL) (&lt; 1.22 mmol/L) have previously been demonstrated to be associated with heightened susceptibility COVID-19 and immediate COVID-19-related adverse outcomes in this patient population. However, the potential association between HDL persistence COVID has not examined within cohort. The study aimed explore...

Abstract Background and Aims Citrulline, an α-amino acid crucial for the urea cycle nitric oxide production, plays a protective role against free radicals is indirectly related to protein metabolism. It synthesized in intestine efficiently absorbed by proximal renal tubules, where it converted via arginine. Although citrulline has multiple physiological effects, its involvement progression of chronic kidney disease (CKD) not been explored. This cross-sectional study aimed investigate...