A5046240073- Malaria Research and Control
- Traditional and Medicinal Uses of Annonaceae
- Drug-Induced Hepatotoxicity and Protection
- Ethnobotanical and Medicinal Plants Studies
- Pharmacological Effects of Natural Compounds
- Mangiferin and Mango Extracts
- Synthesis and bioactivity of alkaloids
- Natural Antidiabetic Agents Studies
- Morinda citrifolia extract uses
- Alkaloids: synthesis and pharmacology
- Computational Drug Discovery Methods
- Phytochemistry and biological activity of medicinal plants
- Mosquito-borne diseases and control
- Chemical synthesis and alkaloids
- Phytochemical compounds biological activities
- Phytochemistry and Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Seed and Plant Biochemistry
- Bioactive Compounds and Antitumor Agents
- Beetle Biology and Toxicology Studies
- Plant biochemistry and biosynthesis
- Diverse Scientific Research Studies
- Pharmacogenetics and Drug Metabolism
- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
Obafemi Awolowo University
2013-2024
TU Dortmund University
2024
Context: Co-administration of amodiaquine with MAMA decoction (MD), an herbal antimalarial drug comprising the leaves Mangifera indica L. (Anacardiaceae), Alstonia boonei De Wild (Apocynaceae), Morinda lucida Benth (Rubiaceae) and Azadirachta A. Juss (Meliaceae) was investigated. The practice concurrent administration medicines orthodox drugs is currently on increase globally.Objective: study designed to investigate possible enhancement potency as well herb–drug interaction resulting from...
The methanol stem bark extract of
Introduction/Aim. Herbs have been a vital renewable source of medicine throughout human history as large proportion the global population still depends on them for their health benefits. The increasing popularity herbal supplements has raised an obvious concern about overall safety and potential interaction with other drugs in situ. intent was to spur future research herb-drug interactions well mechanisms understand consequences such interactions. Methods. review conducted by systematic...
The toxicity profile of medicinal plants is an important preclinical requirement in the development phytomedicines. cytotoxic and genotoxic effects leaf Uvaria chamae P. Beauv (Annonaceae) stem bark Morinda lucida Benth (Rubiaceae) were investigated order to provide information on their safety as antimalarial plants. methanol extract U. ethanol (70%) M. separately orally administered (125, 250, 750 mg/kg/day) mice for 10 consecutive days. Cyclophosphamide (50 mg/kg, single dose) distilled...
The antimalarial activities of Morinda lucida (MLE), Alstonia boonei (ABE), Curcuma longa (CLE) at 12.5–400 mg kg−1, sulphadoxine-pyrimethamine (S-P), and quinine 0.2–1.7 0.625–10 respectively, were investigated in Plasmodium berghei–infected mice using the 4-d malaria test. Assessment MLE plus S-P, ABE CLE was similarly done. Dose-dependent noted with MLE, ABE, chemosuppression values 39.8–90.5, 0.2–74.8, 34.6–78.4%, respectively. combinations gave 1.8- to 2.5-fold greater than individual...
The prevalence of Plasmodium strains resistant to conventional monotherapy drugs has necessitated the need for more effective and affordable antimalarial agents. This study aimed at evaluating activities some indigenous plants alone in combination with chloroquine a view proffering herbal therapy as an alternative currently used therapy. Extracts obtained separately from decoctions roots Chasmanthera dependens Hochst. (Menispermaceae), Vernonia amygdalina Delile (Asteraceae) methanol extract...
Plamepsin II has been identified as a therapeutic target in the Plasmodium falciparum's life cycle and may lead to drastic reduction deaths caused by malaria worldwide. Africa flora is rich medicinal qualities possesses both simple complex bioactive phytochemicals. This study utilized computational approaches like molecular docking, dynamics simulation, quantum chemical calculations ADMET evaluate plasmepsin inhibitory properties of phytochemicals isolated from African antimalarial plants....
Background: MAMA Decoction (MD) is prepared from the leaves of Mangifera indica, Alstonia boonei, Morinda lucida and Azadirachta indica. A co-administration MD with amodiaquine led to synergism in clearance malaria parasites a previous report. The pharmacokinetic basis for this observation was subject another study mice which found significant MD- induced increase exposure half-life desethylamodiaquine, major metabolite amodiaquine.Objective: This aimed at evaluating previously identified...
The ethnomedicinal use of Uvaria chamae (P. Beauv) Annonaceae as an antimalarial has been scientifically justified. This study was carried out to determine the pharmacognostic and physicochemical characters its leaf root with a view establishing pharmacopoeial parameters for their quality control. fresh U. chamae, collected authenticated in IFE Herbarium, Obafemi Awolowo University, Nigeria, were preserved ethanol (50%) while some oven-dried powdered. Organoleptic evaluation samples...
MAMA decoction (MD), a preparation from the leaves of Mangifera indica, Alstonia boonei, Morinda lucida, and Azadirachta was co-administered with amodiaquine, resulted in synergistic clearance malaria parasites previous report [1]. The pharmacokinetic basis for this observation, significant increases exposure half-life desethylamodiaquine, major metabolite reported mice [2]. Here, further evaluation these previously identified herb-drug interactions carried out healthy human volunteers.