A5086553536- Molecular Sensors and Ion Detection
- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Renal function and acid-base balance
- Metal-Organic Frameworks: Synthesis and Applications
- Metabolism and Genetic Disorders
- Ion channel regulation and function
- Lipid Membrane Structure and Behavior
University College London
2022-2025
Abstract Ion transport across biological lipid membranes is crucial for both health and disease, prompting investigation into synthetic ion transporters as potential therapeutics. However, state of the art methods assessing transporter activity are often time‐consuming resource‐intensive, hindering screening large compound libraries. In this work we have developed an automated high‐throughput assay capable determining 24 E C 50 values in a single day. This assay, adapted from established...
The design of synthetic membrane transporters for ions is a rapidly growing field research, motivated by the potential medicinal applications novel systems. Metal-organic coordination complexes provide access to wide range geometries, structures and properties their facile synthesis tunability offer advantages in ion transport In this review, application metal-organic constructs as membrane-spanning channels carriers are explored, roles metal within these functional assemblies highlighted.
A combination of computational and synthetic phospholipid vesicle/nanodisc assays are used to investigate the mode action for a class antimicrobial agents, while range DMPK studies establish agent druggability.
Ion transport across biological lipid membranes is crucial for both health and disease, prompting investigation into synthetic ion transporters as potential therapeutics. However, state of the art methods assessing transporter activity are often time-consuming resource-intensive, hindering screening large compound libraries. In this work we have developed an automated high-throughput assay capable determining 24 EC50 values in a single day. This assay, adapted from established lucigenin...
Click to increase image sizeClick decrease size Disclosure statementNo potential conflict of interest was reported by the author(s).