Late stage functionalization (LSF) through direct X-H manipulations (X = C, N) enables synthetic chemists to accelerate the diversification of natural products, agrochemicals and pharmaceuticals allowing rapid access novel bioactive molecules without resorting arduous de novo synthesis. LSF does not only allow tapping hitherto unexplored chemical space but also renders sequence more straightforward, atom economical cost-effective. In this regard, recent decade has witnessed emergence...

Abstract Coatings prepared from polyesteramide resin synthesized linseed oil, a renewable resource, have been found to show improved physicomechanical and anticorrosive characteristics. These properties are further when aluminum is incorporated in the resin. The coatings of this generally obtained by baking at elevated temperatures. With view toward use as precursor for synthesis resins cure their ambient temperature, toluylene diisocyanate (TDI) was into alumina‐filled varying proportions...

Catalytic transfer hydrogenation (TH) for the reduction of heterocycles is an emerging strategy accessing biologically active saturated N-heterocycles. Herein, we report a TH protocol that utilizes ethanol as renewable hydrogen source and Ir catalyst quinolines pyridines. The reaction promoted by simple amides ligands.

Ni-doped LaFeO3 (LFO) microsphere consisting of nanoparticles are synthesized by the hydrothermal route and used for degradation Rhodamine B (RhB) organic dye. The structural, morphological, optical analysis is confirmed various characterization techniques, i.e., X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), UV-Visible spectroscopy. all LFO catalyst shows excellent efficiency towards photocatalytic RhB LFNO-0.2 highest 89.44% with rate constant (k) correlation...

The two donor modules of an annelated pyridyl–mesoionic carbene ligand (aPmic) have different σ- and π-bonding characteristics leading to its electronic asymmetry. A Pd(II) complex 1 featuring aPmic catalyzes the oxidation a wide range terminal olefins corresponding methyl ketones in good excellent yields acetonitrile. catalytic reaction is proposed proceed via syn-peroxypalladation subsequent rate-limiting 1,2-hydride shift, which supported by kinetic studies. asymmetry renders well-defined...

The catalytic utility of [RuL1(CO)2I2] (1), containing an annelated π-conjugated imidazo-naphthyridine-based mesoionic carbene (MIC) ligand (L1), is evaluated for E-selective alkyne semihydrogenation. precatalyst 1, in combination with 2 equiv AgBArF, semihydrogenates a broad range internal alkynes molecular hydrogen (5 bar) water. (E)-Alkenes are accessed high yields, and number reducible functional groups tolerated. A chelate MIC two cis carbonyls provide well-defined platform at the Ru...

The remarkable mechanical and chemical characteristics of graphene have garnered significant interest in scientific investigations aimed at addressing severe environmental problems energy shortages. A concerning problem is the careless disposal industrial wastes that contain a variety organic contaminants water bodies. In order to create ADGCAAQ light harvesting photocatalyst, simple extremely effective condensation process involving 1, 4-diamino anthraquinone (AAQ) generated from aloe vera...

The difficulty in isolating cyclic enamines emanating from their intrinsic instability has impeded exploration cycloaddition reactions. Here, we achieved a metal-free domino reaction providing quinoline and isoquinoline-derived amidines by the of azides with situ generated via dearomatization.

A Ru complex, stabilized by an annulated mesoionic carbene ligand, catalyzes the aerobic oxidation of a host primary amines to amides in high yields and excellent selectivity. Kinetics, Hammett DFT studies provide mechanistic insight.

A sulfonate-functionalized water-soluble Ni( ii )–NHC catalyst is utilized for the oxidative deamination of benzyl amines, wherein water acts as a formal oxidant to give an aldehyde, which then converted useful products.

Cross coupling reactions constitute a useful and efficient approach utilized primarily in the synthesis of carbon–carbon bonds modern organic synthesis. Among this class reactions, Suzuki–Miyaura reaction, Sonogashira, Mizoroki–Heck are mostly utilized. Palladium-facilitated cross-coupling have received lot interest from researchers recently. In order to fine-tune catalytic activity metals, different ligands were used complex with them. great variety ligands, Schiff base (SB) major part. The...

A mild, palladium-catalyzed domino Heck-cyclization/alkoxylation sequence of aryl halide tethered allenamides is described, providing regiodivergent indole and indoline derivatives controlled by the N-protecting group. This room temperature reaction provided a functionalizable olefinic moiety with broad substrate scope. Preliminary mechanistic studies support rearrangement an indoline-derived intermediate to indoles N-acetyl forming free (NH) indoles.

Abstract Bio‐derived ethanol is a promising green and sustainable hydrogen‐donor solvent. Herein, we have developed Ir‐catalyzed transfer hydrogenation of ketones aldehydes using as hydrogen source with amides simple ligands. Furthermore, the alkylation tandem alkylation/transfer acetophenones reported ethanol.

Dicarbofunctionalization of unactivated alkenes by palladium-catalyzed domino Heck/intermolecular direct hetero arylation with heteroarenes was developed producing all-carbon quaternary centers.

Herein, we have developed the cyclic diaryliodonium salts as biarylating agents in C(sp3)–H functionalization using 8-methyl quinoline intrinsic directing group. The oxidant-free reaction produces a vast array of biarylated products with iodo functionality that can be further functionalized. Additionally, intramolecular stepwise manner under palladium-catalyzed conditions produced fluorene derivatives excellent yields.

A domino reaction sequence of cyclopropanation/ring-opening/iminium cyclization tryptamine derivatives with donor-acceptor diazo compounds is developed to furnish pyrroloindolines, creating three consecutive stereogenic centers in a single step. The copper-catalyzed provides pyrroloindolines at room-temperature good substrate scope.

Abstract Cascade dearomative functionalization is a robust protocol to convert flat arenes into medicinally relevant three‐dimensional architectures with added new functionality. Herein, cycloaddition for synthesizing tetrahydroquinoline‐embedded α‐tertiary amine scaffolds has been developed employing quinolinium salts and sulfonyl azides under metal‐free conditions. An underexplored mechanistically distinct pathway unveiled, creating quaternary‐center‐bearing skeletons by an group migration...

The recently described crystalline cyclic (alkyl)(amino)carbene with a 1,1’‐ferrocenylene (fc) backbone fc(CPh2–C–NMes) (A, Mes = mesityl) is highly reactive due to its particularly pronounced ambiphilicity and thermally not stable in solution an intramolecular insertion of the divalent carbon atom into methyl C–H bond substituent. closely related congener fc(CPh2–C–N‐p‐C6H4‐tBu) (1) cannot undergo such reaction. Nevertheless, 1 too short‐lived for isolation rapid 1,2‐shift phenyl group,...

A new one-pot, three-component synthesis of 2,3,5-substituted (or 2,3-annulated)-6-(methylthio)pyridines by reacting acyclic or cyclic active methylene ketones, ammonium acetate, and bis(methylthio)acrolein (1) its 2-phenyl analogue 8 (as 3-carbon-1,3-biselectrophilic components) in the presence either AcOH-TFA (4:1) ZnBr2 ZnI2) catalysts has been reported.

Abstract The catalytic activity of a Ru complex 1 , bearing fused π‐conjugated imidazo[1,2– ][1,8]naphthyridine‐based mesoionic carbene (MIC) ligand, is examined for the oxidation primary amines. Complex affords nitrile or imine depending on nature terminal oxidants and solvents used in reactions. Primary amines are converted to nitriles using NaIO 4 EtOAc/H 2 O mixture, whereas imines obtained under balloon pressure toluene. A variety accessed with high yields selectivity. set control...

Abstract An antipolution polymer strip (APPS) was designed using a cellulose (8 × 3 cm) coated with disinfectant resin followed by impregnation transitional metals (100 μm each). The present studies focused primarily on protection of animals, especially humans, from carbon monoxide (CO) in the atmosphere because incomplete combustion fuel motor vehicles. Diffusion atmospheric CO gas causes air pollution. Human blood absorbs atmosphere, resulting breathing difficulty and various other...