A5069038802- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Hearing, Cochlea, Tinnitus, Genetics
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Nutrition, Genetics, and Disease
- Bacteriophages and microbial interactions
- Nutritional Studies and Diet
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Sleep and Wakefulness Research
- Glycosylation and Glycoproteins Research
- Visual perception and processing mechanisms
- Dietary Effects on Health
- Optical Coherence Tomography Applications
- Transcranial Magnetic Stimulation Studies
- vaccines and immunoinformatics approaches
- Neural and Behavioral Psychology Studies
- Photonic Crystals and Applications
University of California, San Diego
2017-2024
Georgia Institute of Technology
2024
University of California, Riverside
2011-2022
UC San Diego Health System
2019
Indiana University Bloomington
2004-2012
Indiana University
2006
Significance Resting-state infra-slow brain activity fluctuations are observed across various cognitive and disease states. Although resting-state have received a great deal of interest over the past few years, underlying biophysical mechanisms not known. Using computational modeling, we show that spontaneous arise from dynamic ion concentrations influenced by Na + /K pump, glial K buffering, AMPA/GABA synaptic currents. These findings provide insights into generation this phenomenon may...
Patients with bipolar disorder show cognitive deficits and disorganized behavior, which may reflect a disturbance in neural synchronization. We tested whether EEG measures of auditory synchronization were abnormal disorder. Nineteen symptomatic patients 32 non-psychiatric control subjects evaluated. Click trains (500 ms duration) presented at 20, 30, 40 50 Hz used to evoke showed reduced power across the frequencies stimulation. Phase-locking trials was also disturbed disorder, consistent...
Rass O, Krishnan G, Brenner CA, Hetrick WP, Merrill CC, Shekhar A, O’Donnell BF. Auditory steady state response in bipolar disorder: relation to clinical state, cognitive performance, medication status, and substance disorders. Bipolar Disord 2010: 12: 793–803. © 2010 The Authors. Journal compilation John Wiley & Sons A/S. Objectives: Abnormalities auditory (ASSR) at gamma range frequencies have been found disorder, but the relationship of these neurophysiological disturbances factors...
Objective: Cannabis use may produce neurophysiological disturbances similar to those observed in schizophrenia, particularly relation altered neural synchronization. Therefore, the current experiment examined effect of cannabis on EEG synchronization using auditory steady-state evoked potential. Method: Auditory potentials were assessed varying rates stimulation (auditory click-trains 20, 30, 40 Hz) users (N=17) and drug-naive comparison subjects (N=16). spectral power signal-to-noise ratio...
Auditory steady-state auditory responses (ASSRs), in which the evoked potential entrains to stimulus frequency and phase, are reduced magnitude patients with schizophrenia, particularly at 40 Hz. While neural mechanisms responsible for ASSR generation its perturbation schizophrenia unknown, it has been hypothesized that GABAA receptor subtype may have an important role. Using established rat model of neonatal ventral hippocampal lesion (NVHL) model, 40-Hz ASSRs were elicited from NVHL sham...
The Auditory Steady-State Response (ASSR) in the electroencephalogram (EEG) is usually reduced schizophrenia (SZ), particularly to 40 Hz stimulation. gamma frequency ASSR deficit has been attributed N-methyl-D-aspartate receptor (NMDAR) hypofunction. We tested whether NMDAR antagonist, phencyclidine (PCP), produced similar deficits rats. EEG was recorded from awake rats via intracranial electrodes overlaying auditory cortex and at vertex of skull. ASSRs click trains were 10, 20, 30, 40, 50,...
Nutritional phenotyping can help achieve personalized nutrition, and machine learning tools may offer novel means to phenotyping. The primary aim of this study was use energy balance components, namely input (dietary intake macronutrient composition) output (physical activity) predict stores (body weight) as a way evaluate their ability identify potential phenotypes based on these parameters. From the Women's Health Initiative Observational Study (WHI OS), carbohydrates, proteins, fats,...
Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it known that neuromodulation of alertness impact resting-state activity, neural mechanisms behind such modulation are unknown. In this work, we a computational model demonstrate change excitability recurrent connections, due cholinergic modulation, impacts activity. The results match closely with experimental work on direct Default Mode Network (DMN)...
<i>Background/Aims:</i> The neonatal ventral hippocampal lesion (NVHL) rat model shows biological and behavioral abnormalities similar to schizophrenia. Disturbed sensory gating reflects a consistent neurobiological abnormality in Although of critical interest, has not been evaluated the NVHL model. <i>Methods:</i> N40 analog human P50 was measured assess response sham rats. Epidural electrodes recorded evoked potentials (EPs), from which amplitudes, latencies,...
This paper introduces Cybershuttle, a new type of user-facing cyberinfrastructure that provides seamless access to range resources for researchers, enhancing their productivity. The Cybershuttle Research Environment is built on open source Apache Airavata software and uses hybrid approach integrates locally deployed agent programs with centrally hosted middleware. enables end-to-end integration computational science engineering research across resources, including users' local centralized...
When a moving stimulus is presented at specific temporal frequency, both steady-state responses and induced γ activity may be elicited in the electroencephalogram. The electroencephalogram was recorded when study participants viewed random dot kinematograms under three conditions: coherent motion, incoherent motion stationary. Dot position changed rate of 9.3 Hz conditions. Induced power 40 increased during compared with other In contrast, response showed trend for condition. These results...
Increase of the extracellular K( + ) concentration mediates seizure-like synchronized activities in vitro and was proposed to be one main factors underlying epileptogenesis some types seizures vivo. While biophysical mechanisms clearly involve cell depolarization overall increase excitability, it remains unknown what qualitative changes spatio-temporal network dynamics occur after increase. In this study, we used multi-electrode recordings from mouse hippocampal slices explore activity...
Artificial neural networks (ANNs) are known to suffer from catastrophic forgetting: when learning multiple tasks, they perform well on the most recently learned task while failing previously tasks. In biological networks, sleep is play a role in memory consolidation and incremental learning. Motivated by processes that be involved generation we developed an algorithm implements sleep-like phase ANNs. framework, demonstrate able recover older tasks were otherwise forgotten. We show creates...
In this paper, we introduce and study systematically, in terms of phase response curves, the effect dual-pulse excitation on dynamics an autonomous oscillator. Specifically, test deviations from linear summation advances resulting two small perturbations. We analytically derive a correction term, which generally appears for oscillators whose intrinsic dimensionality is $>$1. The nonlinear term found to be proportional square perturbation. demonstrate Stuart-Landau model various higher...
Background: The N-glycan structure and composition of the spike (S) protein SARS-CoV-2 are pertinent to vaccine development efficacy. Methods: We reconstructed glycosylation network based on previously published mass spectrometry data using GNAT, a analysis tool. Our compilation tool had 26 glycosyltransferase glucosidase enzymes could infer pathway machinery glycans in virus protein. Once glycan biosynthesis was generated, we simulated effect blocking specific enzymes-swainsonine or...