A5101696232- Drug Transport and Resistance Mechanisms
- Lattice Boltzmann Simulation Studies
- Advanced Numerical Methods in Computational Mathematics
- Computer Graphics and Visualization Techniques
- Amino Acid Enzymes and Metabolism
- Fluid Dynamics and Turbulent Flows
- Building Energy and Comfort Optimization
- Coronary Interventions and Diagnostics
- Computational Fluid Dynamics and Aerodynamics
- Cardiac Valve Diseases and Treatments
- Cancer therapeutics and mechanisms
- Infection Control and Ventilation
- Computational Geometry and Mesh Generation
- Heat Transfer and Optimization
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Pharmacological Effects and Toxicity Studies
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hormonal Regulation and Hypertension
- Cystic Fibrosis Research Advances
- Fluid Dynamics and Vibration Analysis
- Trace Elements in Health
- Catalytic Processes in Materials Science
Iowa State University
2020-2023
Albert Einstein College of Medicine
1990-2005
Memorial Sloan Kettering Cancer Center
1990
Cancer Research Center
1990
Icahn School of Medicine at Mount Sinai
1978
P-glycoprotein is a 130-180-kDa integral membrane protein that overproduced in multidrug-resistant cells. The appears to act as an energy-dependent drug efflux pump has broad specificity for structurally diverse hydrophobic antitumor drugs. Many agents, such the calcium channel blocker verapamil, reverse multidrug resistance and also interact with P-glycoprotein. goal of this work was determine if common binding site participates transport drugs and/or reversal resistance. This done by...
P-glycoprotein is an integral membrane protein that overproduced in multidrug-resistant cells. It likely to function as energy-dependent drug efflux pump maintain intracellular concentrations below cytotoxic levels. Individually isolated murine cell lines, J7.V1-1 and J7.V3-1, overproduce P-glycoproteins encoded by the mdr1b mdr1a genes, respectively. The transport properties of these lines binding characteristics their have been compared. concluded 1) gene product a more efficient than...
Multiphase fluid dynamics, such as falling droplets and rising bubbles, are critical to many industrial applications. However, simulating these phenomena efficiently is challenging due the complexity of instabilities, wave patterns, bubble breakup. This paper investigates potential scientific machine learning (SciML) model dynamics using neural operators foundation models. We apply sequence-to-sequence techniques on a comprehensive dataset generated from 11,000 simulations, comprising 1...
P-glycoprotein is phosphorylated in cells, and it has been suggested that phosphorylation may regulate the drug transport activity of P-glycoprotein.Domain mapping, utilizing a combination cyanogen bromide digestion immunoblot analysis, was used to reveal major sites murine rndrlb P-glycoprotein.After labeling J7.Vl-1 cells with [s2P]Pi, or membranes [yS2P]ATP either protein kinase A C, found majority label contained within single fragment (amino acid 627-682) encompassed linker region.The...
Valvular pathologies that induce deterioration in the aortic valve are a common cause of heart disease among aging populations. Although there numerous available technologies to treat valvular conditions and replicate normal function by replacing diseased with bioprosthetic implant, many these devices face challenges terms long-term durability. One such phenomenon may exacerbate undesirable hemodynamic effects aorta is leaflet flutter, which characterized oscillatory motion biological...
The development of multidrug resistance (MDR) is associated with the overproduction a plasma membrane glycoprotein, P glycoprotein. Here we report functional expression member murine mdr family proteins and show that Xenopus oocytes injected RNA encoding mouse mdr1b glycoprotein develop MDR-like phenotype. Immunological analysis indicated synthesized protein size immunological characteristics These exhibited decreased accumulation [3H]vinblastine showed an increased capacity to extrude drug...
Journal Article Modulation of the Function p-glycoprotein by Estramustine Get access Chia-Ping Huang Yang, Yang Search for other works this author on: Oxford Academic PubMed Google Scholar Heng-Jia Shen, Shen Susan Band Horwitz *Department Molecular Pharmacology, Albert Einstein College MedicineBronx, N. Y. Correspondence to : Horwitz, Ph.D., Department Medicine, 1300 Morris Park Ave., Bronx, NY 10461. JNCI: National Cancer Institute, Volume 86, Issue 9, 4 May 1994, Pages 723–725,...
Simulating fluid flow around arbitrary shapes is key to solving various engineering problems. However, simulating physics across complex geometries remains numerically challenging and computationally resource-intensive, particularly when using conventional PDE solvers. Machine learning methods offer attractive opportunities create fast adaptable benchmark datasets measure the performance of such are scarce, especially for geometries. We introduce FlowBench, a dataset neural simulators with...
We extend the shifted boundary method (SBM) to simulation of incompressible fluid flow using immersed octree meshes. Previous work on SBM for primarily utilized two- or three-dimensional unstructured tetrahedral grids. Recently, grids have become an essential component CFD solvers, and this addresses gap associated computational challenges. leverage optimal (approximate) surrogate constructed efficiently incomplete adaptive The resulting framework enables Navier-Stokes equations in complex...
This paper presents the application of Shifted Boundary Method (SBM) to thermal flow simulations, utilizing incomplete octree meshes (Octree-SBM) perform multiphysics simulations that couple and heat transfer. By employing a linearized form Navier-Stokes equations, we accelerate while maintaining accuracy. SBM enables precise enforcement field derivative boundary conditions on intercepted elements, allowing for accurate flux calculations near complex geometries, when using non-boundary...
We present a high-level domain-specific language (DSL) interface to drive an adaptive incomplete $k$-d tree-based framework for finite element (FEM) solutions PDEs. This DSL provides three key advances: (a) it abstracts out the complexity of implementing non-trivial FEM formulations, (b) simplifies deploying these formulations on arbitrarily complicated and adaptively refined meshes, (c) exhibits good parallel performance. Taken together, allows end-users rapidly efficiently prototype new...
The accurate and efficient simulation of Partial Differential Equations (PDEs) in around arbitrarily defined geometries is critical for many application domains. Immersed boundary methods (IBMs) alleviate the usually laborious time-consuming process creating body-fitted meshes complex geometry models (described by CAD or other representations, e.g., STL, point clouds), especially when high levels mesh adaptivity are required. In this work, we advance field IBM context recently developed...
9663 Background: The extreme drug resistance (EDR) assay is an in vitro chemoresistance assay. correlation between EDR results and clinical response to chemotherapy patients with ovarian cancer has been questioned. We developed five primary epithelial cell lines (SS2 SS6) from ascites histologically confirmed cancer. ex-vivo chemosensitivity was tested these microtubule stabilizing agents (MSA): Taxol, epothilone B (EpoB), discodermolide. Mutation tubulin one of the mechanisms MSA p53 status...
Abstract The ongoing COVID-19 pandemic has rendered confined spaces as high-risk areas. There is an increasing push to resume in-person activities, for instance, teaching in K-12 and university settings. It becomes important evaluate the risk of airborne disease transmission while accounting physical presence humans, furniture, electronic equipment, well ventilation. Here, we present a computational framework based on detailed flow physics simulations that allows straightforward evaluation...