A5039302958- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Genetic Syndromes and Imprinting
- Genetic and phenotypic traits in livestock
- Health, Environment, Cognitive Aging
- Asthma and respiratory diseases
- Gut microbiota and health
- Reproductive Biology and Fertility
- Genetic Mapping and Diversity in Plants and Animals
- BRCA gene mutations in cancer
- Pregnancy and preeclampsia studies
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Health disparities and outcomes
- Hemispheric Asymmetry in Neuroscience
- Cancer-related gene regulation
- Ovarian function and disorders
- Survey Methodology and Nonresponse
- Economic and Environmental Valuation
- Genetic factors in colorectal cancer
- Food Security and Health in Diverse Populations
- Genomics and Rare Diseases
- Diet and metabolism studies
Avera McKennan Hospital & University Health Center
2017-2025
Avera Health
2021-2022
Vrije Universiteit Amsterdam
2021
Abstract Background The gut microbiota composition is known to be influenced by a myriad of factors including the host genetic profile and number environmental influences. Here, we focus on influence cohabitation as well whether these environmentally microorganisms are associated with cardiometabolic inflammatory burden. We perform this investigating various groups related individuals cohabitating monozygotic (MZ) twin pairs, non-cohabitating MZ pairs spouse pairs. Results A stronger...
Abstract Background Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated relationship between DNA methylation 35 clinical markers of asthma. Methods The Illumina Infinium EPIC v1 array was used to evaluate 742,442 CpGs whole blood from 319 participants 94 families. They were part Netherlands Twin Register families at least one member suffering severe Repeat samples taken after 10 years 182 individuals. Principal...
Telomere length has garnered interest due to the potential role it may play as a biomarker for cellular aging process. measurements obtained from blood-derived DNA are often used in epidemiological studies. However, invasive nature of blood draws severely limits sample collection, particularly with children. Buccal cells commonly sampled isolation and thus present non-invasive alternative telomere measurement. leukocyte derived samples collected at same time period were analyzed repeat mass...
We examined the performance of methylation scores (MS) and polygenic (PGS) for birth weight, BMI, prenatal maternal smoking exposure, status to assess extent which MS could predict these traits exposures over above PGS in a multi-omics prediction model. may be seen as epigenetic equivalent PGS, but because their dynamic nature sensitivity non-genetic add complex trait independently PGS. were calculated based on genotype data DNA-methylation blood samples from adults (Illumina 450 K; N =...
Objective: The human gut microbiota has been demonstrated to be associated with a number of host phenotypes, including obesity and obesity-associated phenotypes. This study is aimed at further understanding describing the relationship between measurements obtained from participants. Subjects/Methods: Here, we utilize genetically informative designs, four-corners design (extremes genetic risk for BMI observed BMI; N = 50) monozygotic (MZ) discordant twin pair ( 30), in order help delineate...
The field of DNA methylation research is rapidly evolving, focusing on disease and phenotype changes over time using measurements from diverse tissue sources multiple array platforms. Consequently, identifying the extent longitudinal, inter-tissue, inter-platform variation in crucial for future advancement. was measured 375 individuals, with 197 those having 2 blood sample ~10 years apart. Whole-blood samples were Illumina Infinium 450K EPIC arrays, buccal a subset 58 participants array....
Abstract Here we provide an update of the 2013 report on Nigerian Twin and Sibling Registry (NTSR). The major aim NTSR is to understand genetic environmental influences their interplay in psychological mental health development children adolescents. Africans have highest twin birth rates among all human populations, Nigeria most populous country Africa. Due its combination large population high rates, has one largest populations world. In this article, current updates samples recruited,...
Female fertility is a complex trait with age-specific changes in spontaneous dizygotic (DZ) twinning and fertility. To elucidate factors regulating female infertility, we conducted genome-wide association study (GWAS) on mothers of DZ twins (MoDZT) versus controls (3273 cases, 24,009 controls). This follow-up to the Australia/New Zealand (ANZ) component that previously reported (Mbarek et al., 2016), sample size almost twice entire discovery meta-analysed previous article (and five times ANZ...
Breast cancer (BC) is a complex disease affecting one in eight women the USA. Advances population genomics have led to development of polygenic risk scores (PRSs) with potential augment current models, but replication often limited. We evaluated 2 robust PRSs 313 and 3820 SNPs effects multiple genotype imputation replications BC cases control populations. Biological samples from cancer-free controls were drawn three European ancestry cohorts. Genotyping on Illumina Global Screening Array was...
Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated relationship between DNA methylation 35 clinical markers of asthma. The Illumina Infinium EPIC v1 array was used to evaluate 742,442 CpGs whole blood samples from 319 participants. They were part Netherlands Twin Register families at least one member suffering severe Repeat taken after 10 years 182 these individuals. Principal component analysis (PCA) on yielded...
Abstract Natural dizygotic twinning (DZT) results from hyper-ovulation and is considered an indicator of female fertility. DZT has low polygenicity, with only 0.20% SNPs estimated to have a nonzero effect. A polygenic score (PGS) for explains 1.6% variance in liability we observe odds ratio 2.29 between the 1 st 10 th PGS decile. The higher mothers naturally conceived twins compared who received fertility (MAR) treatments both Netherlands Norway. largest differences were observed hormonal...
Accurate inference of genetic ancestry is crucial for population-based association studies, accounting population heterogeneity and structure. This study analyzes genome-wide SNP data from the Netherlands Twin Register to compare estimates. The focus on comparison estimates between family members individuals genotyped multiple arrays (Affymetrix 6.0, Affymetrix Axiom, Illumina GSA). Two conventional methods, principal component analysis ADMIXTURE, were implemented estimate ancestry, each...