A5079228393- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Antimicrobial Peptides and Activities
- Photochromic and Fluorescence Chemistry
- Luminescence and Fluorescent Materials
- Proteoglycans and glycosaminoglycans research
- Organic Chemistry Cycloaddition Reactions
- Nanocluster Synthesis and Applications
- Amino Acid Enzymes and Metabolism
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Supramolecular Chemistry and Complexes
University of Trieste
2018-2024
Diphenylalanine is an amyloidogenic building block that can form a versatile array of supramolecular materials. Its shortcomings, however, include the uncontrolled hierarchical assembly into microtubes heterogeneous size distribution and well-known cytotoxicity. This study rationalized heterochirality as successful strategy to address both these pitfalls it provided unprotected heterochiral dipeptide self-organized homogeneous optically clear hydrogel with excellent ability sustain...
Self-assembling peptides are being applied both in the biomedical area and as building blocks nanotechnology. Their applications closely linked to their modes of self-assembly, which determine functional nanostructures that they form. This work brings together two structural elements direct nanoscale self-association divergent directions: proline a β-breaker β-structure-associated diphenylalanine motif, into single tripeptide sequence. Amino acid chirality was found resolve tension inherent...
The divergent supramolecular behavior of a series tripeptide stereoisomers was elucidated through spectroscopic, microscopic, crystallographic, and computational techniques. Only two epimers were able to effectively self-organize into amphipathic structures, leading hydrogels or crystals, respectively. Despite the similarity between peptides' turn conformations, stereoconfiguration led different abilities engage in intramolecular hydrogen bonding. Self-assembly further shifted pKa value...
In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel obtain drug delivery supramolecular system. The release of was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) its interaction with the assemblies probed all-atom...
Minimalistic and uncapped <sc>d</sc>,<sc>l</sc>-peptides self-assemble into bioadhesive hydrogels that successfully mimic the extracellular matrix lead to high cell viability.
D‐Ser(tBu)‐L‐Phe‐L‐Trp is described as a self‐assembling tripeptide that yields nanofibrillar hydrogels at physiological conditions (phosphate buffer pH 7.4). The peptide characterized by several spectroscopic methods, such circular dichroism and fluorescence, oscillatory rheometry, transmission electron microscopy. Single‐crystal X‐ray diffraction reveals supramolecular packing into water‐bound channels allows the visualization of intermolecular interactions holding together stacks.
Dipeptides and their cyclized 2,5-piperazinedione (or diketopiperazine, DKP) derivatives are attractive building blocks for supramolecular hydrogels. The Phe-Phe, (p-nitro)-Phe-Phe, Phe-Val dipeptides corresponding DKPs studied self-assembly in water. were obtained high yields by microwave-assisted cyclization of the water, demonstrating that use methyl ester as reported literature is not necessary successful cyclization. Single-crystal XRD structures two well stable hydrogels at neutral pH.
The divergent supramolecular behavior of a series tripeptide stereoisomers was elucidated through spectroscopic, microscopic, crystallographic and computational techniques. Only two epimers were able to effectively self-organize into amphipathic structures, leading hydrogels or crystals, respectively. Despite the similarity between peptides’ turn conformations, stereoconfiguration led different abilities engage in intramolecular hydrogen bonding. Self-assembly further shifted pKa C-terminal...