A5005572385- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Chemical Reactions and Isotopes
- Asymmetric Synthesis and Catalysis
- Crystallography and molecular interactions
- Synthesis of β-Lactam Compounds
- Catalytic Cross-Coupling Reactions
Dana-Farber Cancer Institute
2024
Harvard University
2024
Rice University
2017-2019
Given the importance of amines in a large number biologically active natural products, pharmaceutical ingredients, agrochemicals, and functional materials, development efficient C–N bond-forming methods with wide substrate scope continues to be at frontier research synthetic organic chemistry. Here, we present general fundamentally new approach for direct, transition-metal-free preparation symmetrical unsymmetrical diaryl-, arylalkyl-, dialkylamines that relies on facile single or double...
Herein, we present a general synthetic strategy for the preparation of 3-, 4-, 5-, and 6-membered heterocyclic unnatural amino acid derivatives by exploiting facile Mannich-type reactions between readily available N-alkyl- N-aryl-substituted diisopropyl iminomalonates wide range soft anionic C-nucleophiles without using any catalyst or additive. Fully substituted aziridines were obtained in single step when enolates α-bromo esters employed as nucleophiles. Enantiomerically enriched...