Abstract Perception is subjective. Even basic judgments, like those of visual object size, vary substantially between observers and also across the field within same observer. The way in which system determines size objects remains unclear, however. We hypothesize that inferred from neuronal population activity V1 predict idiosyncrasies cortical functional architecture should therefore explain individual differences judgments. Here we show results novel behavioural methods magnetic resonance...

Between-group variability in socioeconomic status (SES) has been identified as a potentially important contributory factor studies reporting cognitive advantages bilinguals over monolinguals (the so called "bilingual advantage"). The present study addresses the potential importance of this alternative explanatory variable low and high SES bilingual monolingual performance on Simon task Tower London (TOL) task. Results indicated an overall response time advantage task, despite equivalent...

Duchenne muscular dystrophy (DMD) is characterized by loss of dystrophin in muscle, however patients also have variable degree intellectual disability and neurobehavioural co-morbidities. In contrast to which a single full-length isoform (Dp427) produced, multiple isoforms are produced the brain, their deficiency accounts for variability CNS manifestations, with increased risk comorbidities carrying mutations affecting 3' end gene, disrupt expression shorter Dp140 Dp71 isoforms. A mouse...

Recent evidence has challenged long-standing claims that multi-language acquisition confers long-term advantages in executive function and may protect against age-related cognitive deterioration. We assessed for a bilingual advantage older monolingual residents matched on age, gender, socioeconomic status. A comprehensive battery of tests was administered to measure non-verbal reasoning, working memory capacity, visuo-spatial memory, response inhibition, problem solving, language...

Accessible summary What is known on the subject? Nursing observations at night are conducted psychiatric wards to ensure safety and well‐being of patients as well reduce risk suicide or severe harm. To our knowledge, no studies have examined lived experience ward environment nursing night. does paper add existing knowledge? The main complaint from was constant interruption their sleep, most in this study were observed 2–4 times an hour. Their sleep interrupted by (a) light torches shone into...

We evaluate brain structure sensitivity to verbal interference in a sentence interpretation task, building on previously reported evidence that those with better control of show higher grey matter density the posterior paravermis right cerebellum. compare across two groups, English monolingual (N = 41) and multilingual 46) adults. Using voxel-based morphometry, our primary goal was identify explore differences regional patterns performance controlling for group variability age, nonverbal...

Serotonin [5-hydroxytryptamine (5-HT)] is known to control prolactin (PRL) release at a hypothalamic level, but pituitary site of action remains poorly studied. The present study explores the acute effect 5-HT on PRL in rat anterior aggregate cell cultures, influence steroid and thyroid hormones, receptor (5-HTR) subtype(s) involved. elicited prompt increase basal release, an strongly potentiated by estradiol (E(2)) culture medium (dose response 1-100 nm). In E(2) condition, was not affected...

How we perceive the environment is not stable and seamless. Recent studies found that how a person qualitatively experiences even simple visual stimuli varies dramatically across different locations in field. Here use method developed recently call multiple alternatives perceptual search (MAPS) for efficiently mapping such biases several locations. This procedure reliably quantifies spatial pattern of also uncertainty choice. We show these measurements are strongly correlated with those from...

During the last two decades brain related comorbidities of Duchenne have received growing scientific and clinical interest therefore systematic assessment cognition, behaviour learning is important. This study aims to describe instruments currently being used in five neuromuscular clinics Europe as well diagnoses made these clinics.A Delphi based procedure was developed by which a questionnaire sent psychologist seven participating Brain Involvement In Dystrophinopathy (BIND) study....

Abstract Perception is subjective. Even basic judgments, like those of visual object size, vary substantially between observers and also across the field within same observer. The way in which system determines size objects remains unclear, however. We hypothesize that inferred from neuronal population activity V1 predict idiosyncrasies cortical functional architecture should therefore explain individual differences judgments. Indeed, using novel behavioral methods magnetic resonance imaging...

Background Triple chronotherapy (sleep deprivation for 36 h, followed by 4 days of advancing the time sleep and daily morning bright-light therapy 6 months) has demonstrated benefits rapid treatment depressive symptoms in four small controlled trials in-patients. Aims To test feasibility recruitment delivery triple out-patients with depression (ISRCTN17706836; NCT03405493). Method In a single-blind trial, 82 participants were randomised to or control intervention. The primary outcome was...

Background: Viral myocarditis is an important cause of heart failure and sudden cardiac death in young adults. Our previous studies have shown that many microRNAs are differentially expressed the during viral myocarditis, including microRNA-221 -222. Therefore we aimed at studying biological role these miRs mice, induced by human Coxsackie B3 virus.

MicroRNAs (miRs) are small non-coding RNAs implicated in fundamental disease processes such as inflammation and immunity by posttranscriptional downregulation of gene expression. Cardiac transplantation (HTX) is a life-saving intervention for end-stage heart failure. Despite contemporary immunosuppressants, acute rejection following HTX occurs up to 50% patients associated with decreased long-term survival. In this study, we aimed list show the therapeutic potential differentially expressed...

Objectives To investigate a novel methodology and explore whether artificially reducing the depth of penetration during intercourse matters to women. Study Design Methods A study with single‐case experimental design (‘ n 1’), in which heterosexual couple act as their own control is then replicated subsequent couples, was conducted. Thirty‐five couples were assessed for eligibility participate. Twenty‐nine without any sexual problems randomized 12 submitted sufficient data analyse. As proxy...

Aims Triple chronotherapy (defined as sleep deprivation for 36 hours, followed by 4 days of advancing the time sleep, together with daily morning bright light therapy 6 months) has demonstrated benefits rapid treatment depressive symptoms in small, controlled trials in-patients. Our aims were to test feasibility recruitment and delivery triple out-patients depression. Method In a single blind trial, 82 participants randomised either or control intervention. The primary outcome was Hamilton...

Duchenne muscular dystrophy (DMD), an X-linked childhood-onset caused by loss of the protein dystrophin, can be associated with neurodevelopmental, emotional and behavioural problems. A DMD mouse model also displays a neuropsychiatric phenotype, including increased startle responses to threat which normalise when dystrophin is restored in brain. We hypothesised that may humans DMD, would have potential translational therapeutic implications. To investigate this, we first designed novel...

Abstract Duchenne muscular dystrophy (DMD), an X-linked childhood-onset caused by loss of the protein dystrophin, can be associated with neurodevelopmental, emotional and behavioural problems. A DMD mouse model also displays a neuropsychiatric phenotype, including increased startle responses to threat which normalise when dystrophin is restored in brain. We hypothesised that may humans DMD, would have potential translational therapeutic implications. To investigate this, we first designed...

Purpose: Viral myocarditis is a life-threatening disease characterized by severe cardiac inflammation that can result in sudden death or congestive heart failure previously healthy adults, and there are no current therapies. Inflammatory cell recruitment necessary to eliminate the virus but also plays large role pathophysiology therefore understanding cellular molecular steps of essential order develop new Methods: In coxsackie B3 (CVB3) murine model viral myocarditis, transcript levels...