Barbara Clyne

ORCID: 0000-0002-1186-9495
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About
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Research Areas
  • Pharmaceutical Practices and Patient Outcomes
  • Health Systems, Economic Evaluations, Quality of Life
  • Chronic Disease Management Strategies
  • Clinical practice guidelines implementation
  • Nutrition and Health in Aging
  • Health Policy Implementation Science
  • Medication Adherence and Compliance
  • Primary Care and Health Outcomes
  • Meta-analysis and systematic reviews
  • Healthcare cost, quality, practices
  • Health Sciences Research and Education
  • Child Nutrition and Feeding Issues
  • Patient Safety and Medication Errors
  • Delphi Technique in Research
  • Mental Health and Patient Involvement
  • Dietetics, Nutrition, and Education
  • Interprofessional Education and Collaboration
  • Sepsis Diagnosis and Treatment
  • Palliative Care and End-of-Life Issues
  • Musculoskeletal pain and rehabilitation
  • Healthcare Quality and Management
  • Emergency and Acute Care Studies
  • Antibiotic Use and Resistance
  • Hip and Femur Fractures
  • Osteoarthritis Treatment and Mechanisms

Health and Safety Authority
2019-2025

Health Information and Quality Authority
2019-2025

University of Medicine and Health Sciences
2022-2025

Royal College of Surgeons in Ireland
2015-2024

Trinity College Dublin
2022-2024

Institute of Public Health
2024

Ollscoil na Gaillimhe – University of Galway
2022-2023

University of Bristol
2023

Health Research Board
2013-2022

Primary Health Care
2020-2022

<h3>PURPOSE</h3> Potentially inappropriate prescribing (PIP) is common in older people and can result increased morbidity, adverse drug events, hospitalizations. The OPTI-SCRIPT study (Optimizing Prescribing for Older People Primary Care, a cluster-randomized controlled trial) tested the effectiveness of multifaceted intervention reducing PIP primary care. <h3>METHODS</h3> We conducted trial among 21 general practitioner practices 196 patients with PIP. Intervention participants received...

10.1370/afm.1838 article EN The Annals of Family Medicine 2015-11-01

OBJECTIVES To develop a core outcome set (COS) for use in effectiveness trials of interventions aiming to improve the appropriateness polypharmacy older people primary care. DESIGN Standard COS development methodology was followed, comprising identification outcomes studies from an update Cochrane systematic review and previously collected qualitative data online Delphi consensus exercise involving three rounds. PARTICIPANTS An international panel 160 stakeholders 120 healthcare experts...

10.1111/jgs.15245 article EN Journal of the American Geriatrics Society 2018-02-20

There is a rising prevalence of multimorbidity, particularly in older patients, and need for evidence-based medicines management interventions this population. The Supporting Prescribing Older Adults with Multimorbidity Irish Primary Care (SPPiRE) trial aimed to investigate the effect general practitioner (GP)-delivered, individualised medication review reducing polypharmacy potentially inappropriate prescriptions (PIPs) community-dwelling patients multimorbidity primary care.

10.1371/journal.pmed.1003862 article EN cc-by PLoS Medicine 2022-01-05

Background Polypharmacy (≥5 medications) is common in older patients and associated with adverse outcomes. Patients’ beliefs about medication can influence their expectations for medication, adherence, willingness to deprescribe. Few studies have examined prescribed among polypharmacy primary care. Aim To explore medication-related factors that might beliefs. Design setting A mixed methods study utilising data from a randomised controlled trial aiming decrease potentially inappropriate...

10.3399/bjgp17x691073 article EN British Journal of General Practice 2017-05-22

Abstract Introduction Problematic polypharmacy is the prescribing of five or more medications potentially inappropriately. Unintentional cascades represent an under-researched aspect problematic and occur when adverse drug reaction (ADR) misinterpreted as a new symptom resulting in initiation medication. The aim this study was to elicit key stakeholders’ perceptions attitudes towards polypharmacy, with focus on cascades. Methods qualitative one-to-one semi-structured interviews were...

10.1093/ageing/afae116 article EN cc-by Age and Ageing 2024-06-01

Potentially inappropriate prescribing (PIP) is common in older people primary care, as evidenced by a significant body of quantitative research. However, relatively few qualitative studies have investigated the phenomenon PIP and its underlying processes from perspective general practitioners (GPs). The aim this paper to explore qualitatively, GP perspectives regarding care patients. Semi-structured interviews were conducted with GPs participating randomised controlled trial (RCT) an...

10.1186/s12875-016-0507-y article EN cc-by BMC Family Practice 2016-08-11

Malnutrition or undernutrition, arising from a deficiency of energy and protein intake, occurs commonly among community-dwelling individuals in developed countries. Once identified, malnutrition can be effectively treated the majority cases with dietary advice prescription oral nutritional supplements (ONS) for patients who eat drink orally. However, previous research has reported inadequate screening treatment community. The aim this qualitative study was to explore general practitioners'...

10.1016/j.clnesp.2020.01.006 article EN cc-by-nc-nd Clinical Nutrition ESPEN 2020-02-06

Objective Limited evidence suggests integration of pharmacists into the general practice team could improve medicines management for patients, particularly those with multimorbidity and polypharmacy. This study aimed to develop assess feasibility an intervention involving pharmacists, working within practices, optimise prescribing in Ireland. Design Non-randomised pilot study. Setting Primary care Participants Four purposively sampled recruited reflect a range sizes demographic profiles....

10.1136/bmjopen-2019-035087 article EN cc-by-nc BMJ Open 2020-06-01

Abstract Background Early warning systems (EWSs) are used to assist clinical judgment in the detection of acute deterioration avoid or reduce adverse events including unanticipated cardiopulmonary arrest, admission intensive care unit and death. Sometimes healthcare professionals (HCPs) do not trigger alarm escalate for help according EWS protocol it is unclear why this case. The aim qualitative evidence synthesis was answer question ‘why HCPs fail protocols?’ findings will inform update...

10.1186/s12873-021-00403-9 article EN cc-by BMC Emergency Medicine 2021-01-28

What is new?Key findings•Evidence syntheses are increasingly drawing on preprint servers as a source for emergent literature COVID-19. Our research group, has conducted large number of rapid reviews broad range public health topics related to We outline several considerations when including preprints in and lessons learned from this process.What adds what known?•Including implications the review process teams should have clear protocol regarding selection coverage bibliographic databases,...

10.1016/j.jclinepi.2021.05.010 article EN cc-by Journal of Clinical Epidemiology 2021-05-19

The number of prescription medicines prescribed to older adults is increasing in Ireland and other countries. This leading higher out-of-pocket medicine expenditure for adults, which has several negative consequences including cost-related non-adherence. study aimed characterise payments, examine their relationship with entitlements, multimorbidity adherence. cross-sectional used 2016 data from a nationally-representative sample aged ≥50 years. Descriptive statistics regression models were...

10.1016/j.rcsop.2025.100565 article EN cc-by Exploratory Research in Clinical and Social Pharmacy 2025-01-20

Objective: To assess impacts of government changes to prescription medicine co-payments on individuals out-of-pocket expenditure. Methods: Data from The Irish Longitudinal Study Ageing were used. Participants community-dwelling adults aged ≥56 years. Ireland has two cost-sharing schemes: the General Medical Services (GMS) scheme (primarily for low-income populations), involving a low monthly payment cap and co-payments, Drugs Payment Scheme (DPS) (for others), with higher no co-payment...

10.1101/2025.01.21.25320791 preprint EN cc-by-nc medRxiv (Cold Spring Harbor Laboratory) 2025-01-22

Abstract Background People with multimorbidity (i.e., two or more chronic conditions) experience increased out-of-pocket healthcare costs and are vulnerable to cost-related non-adherence recommended treatment. The aim of this study was understand how people prioritise different services when faced tighter budget constraints they non-adherence. Methods A national cross-sectional online survey incorporating a choice experiment conducted. Participants were adults aged 40 years over at least one...

10.1186/s12875-025-02738-9 article EN cc-by BMC Primary Care 2025-02-27
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