A5063274146- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Retinal Development and Disorders
- Vestibular and auditory disorders
- Photoreceptor and optogenetics research
- Transcranial Magnetic Stimulation Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Heavy Metal Exposure and Toxicity
- Neurobiology and Insect Physiology Research
- Odor and Emission Control Technologies
- Functional Brain Connectivity Studies
- ECG Monitoring and Analysis
- Biochemical Analysis and Sensing Techniques
- Cardiac Arrest and Resuscitation
- Pesticide Exposure and Toxicity
Epitel (United States)
2018-2025
University of Utah
2003-2022
University of Colorado Anschutz Medical Campus
2021
University of Michigan
2005-2010
Interface (United States)
2003
Electrographic status epilepticus (ESE) is a medical emergency consisting of repetitive seizures and may result in death or severe brain damage. Epilepsy can develop following ESE. The properties ESE (e.g., duration intensity) are variable, as the effects putative therapeutic treatments. Therefore straightforward method to quantify different components would be beneficial for both researchers clinicians. A frequency range close gamma band was selected extraction seizure-related activity from...
Abstract Objective Reduced‐channel wearable electroencephalography (EEG) may overcome the accessibility and patient comfort limitations of traditional ambulatory electrographic seizure monitoring during extended‐duration use. Automated algorithms are necessary for review reduced‐channel EEG, yet current clinical support software is designed only full‐montage recordings. Methods The performance a novel automated detection algorithm EEG (Epitel) was evaluated in validation study involving 50...
Serial EEG recordings from immature rat pups are extremely difficult to obtain but important for analyzing animal models of neonatal seizures and other pediatric neurological conditions as well normal physiology. In this report, we describe the features applications a novel miniature telemetry system designed record in young postnatal day 6 (P6). First, have recorded electrographic seizure activity two seizures, hypoxia- kainate-induced at P7. Second, viable approach long-term continuous...
Recording seizures using personal seizure diaries can be challenging during everyday life and many are missed or mis-reported. People living with epilepsy could benefit by having a more accurate objective wearable EEG system for counting that used outside of the hospital. The this study was to (1) determine which types electrographically recorded from scalp below hairline, (2) epileptologists' ability identify electrographic single-channels extracted full-montage wired-EEG, (3) Epilog,...
Summary Objective Common data elements ( CDEs ) are currently unavailable for mobile health mH ealth) in epilepsy devices and related applications. As a result, despite expansive growth of new digital services people with epilepsy, information collected is often not interoperable or directly comparable. We aim to correct this problem through development industry‐wide standards ealth data. Methods Using group stakeholders from industry, academia, patient advocacy organizations, we offer...
Electrocorticogram (ECoG) recordings of the 6-hydroxydopamine (6-OHDA)-lesioned parkinsonian rat have shown an increase in power cortical beta-band (15-30 Hz) oscillations ipsilateral to lesion. The these is decreased with dopamine agonist administration. Here, we demonstrate that stimulation electrode implanted subthalamic nucleus alters beta and gamma 6-OHDA-lesioned animals. These alterations are dependent on frequency, charge, amplitude/pulse width. Oscillations were significantly...
Exposure to nerve agents (NAs) and other organophosphates (OPs) can initiate seizures that rapidly progress status epilepticus (SE). While the electrographic neuropathological sequelae of SE evoked by NAs OPs have been characterized in adult rodents, they not adequately investigated immature animals. In this study postnatal day (PND) 14, 21 28 rat pups, along with PND70 animals as controls, were exposed (sarin, VX) or another OP (diisopropylfluorophosphate, DFP). We then evaluated behavioral...
Many progressive neurologic diseases in humans, such as epilepsy, require pre-clinical animal models that slowly develop the disease order to test interventions at various stages of process. These are particularly difficult implement immature rodents, a classic model organism for laboratory study these disorders. Recording continuous EEG young seizures and other neurological disorders presents technical challenge due small physical size rodents their dependence on dam prior weaning....
Epitel has developed Epilog, a miniature, wireless, wearable electroencephalography (EEG) sensor. Four Epilog sensors are combined as part of Epitel's Remote EEG Monitoring platform (REMI) to create 10 channels for remote patient monitoring. REMI is designed provide comprehensive spatial recordings that can be administered by non-specialized medical personnel in any center. The purpose this study was determine how accurate epileptologists at remotely reviewing sensor the 10-channel “REMI...
Objective. Cortical electrical stimulation (CES) has been used extensively in experimental neuroscience to modulate neuronal or behavioral activity, which led this technique be considered neurorehabilitation. Because the cortex and surrounding anatomy have irregular geometries as well inhomogeneous anisotropic properties, mechanism by CES therapeutic effects is poorly understood. Therapeutic of can improved optimizing parameters based on various target brain regions. Approach. In study we...
The relationship among neonatal seizures, abnormalities of the electroencephalogram (EEG), brain injury, and long-term neurological outcome (e.g., epilepsy) remains controversial. effects hypoxia alone (Ha) hypoxia-ischemia (HI) were studied in rats at postnatal day 7; both models generate EEG seizures during 2-h treatment, but only HI causes an infarct with severe neuronal degeneration. Single-channel, differential recordings acute background suppression recorded a novel miniature telemetry...
Closed-loop neural interface technology that combines ensemble decoding with simultaneous electrical microstimulation feedback is hypothesized to improve deep brain stimulation techniques, neuromotor prosthetic applications, and epilepsy treatment. Here we describe our iterative results in a rat model of sensory motor neurophysiological control system. Three rats were chronically implanted microelectrode arrays both the visual cortices. The subsequently trained over period weeks modulate...
While the development of microelectrode arrays has enabled access to disparate regions a cortex for neurorehabilitation, neuroprosthetic and basic neuroscience research, accurate interpretation signals manipulation cortical neurons depend upon anatomical placement electrode in layered cortex. Toward this end, report compares two vivo methods identifying electrodes linear array spaced 100 µm apart based on situ laminar analysis (1) ketamine-xylazine-induced field potential oscillations rat...
Understanding how mammals process olfactory stimuli has motivated the development of tools and techniques which permit simultaneous study finely structured spatial temporal patterns neural activity. A technique is described that uses an array 32 penetrating microelectrodes implanted bilaterally into dorsal aspect rat bulb to investigate responses mitral tufted neurons stimulation with simple enantiomer odor pairs at a number concentrations. It shown stable, recordings from up 49 single-...
This study offers evidence that long-term deep brain stimulation of the ventromedial hypothalamus (VMH) can alter weight gain in mammals without affecting feeding behavior. Animals stimulated unilaterally at high frequencies 150 or 500 Hz demonstrated increased CO(2) production decreased from prestimulation levels after was removed. for up to 6 weeks gained a lower rate than normal animals implanted with an electrode but not stimulated. Stimulated exhibited food and water consumption. A...
Populations of output neurons in the mammalian olfactory bulb (OB) exhibit distinct, widespread spatial and temporal activation patterns when stimulated with odorants. However, questions remain as to how ensembles mitral/tufted (M/T) OB represent odorant information. In this report, single-trial encoding limits random putative single- multiunit M/T cells anesthetized rat during presentations enantiomers limonene, carvone, 2-butanol are investigated using simultaneous multielectrode recording...
Many progressive neurologic diseases in humans, such as epilepsy, require pre-clinical animal models that slowly develop the disease order to test interventions at various stages of process. These are particularly difficult implement immature rodents, a classic model organism for laboratory study these disorders. Recording continuous EEG young seizures and other neurological disorders presents technical challenge due small physical size rodents their dependence on dam prior weaning....
Electrographic seizures and abnormal background activity in the neonatal electroencephalogram (EEG) may differentiate between harmful versus benign brain insults. Using two animal models of seizures, electrical was recorded freely behaving rats examined quantitatively during successive time periods with field-potential recordings obtained shortly after insult (i.e., 0-4 days). Single-channel, differential miniature wireless telemetry were used to analyze spontaneous electrographic...
Electrocorticogram (ECoG) recordings of the 6-OHDA lesioned rat have shown an increase in power beta (15-30 Hz) oscillatory frequency on side brain which reduces with dopamine agonist administration. Here, we were able to demonstrate that implantation and stimulation electrode at certain physiologic parameters subthalamic nucleus was modify oscillations. By measuring ECoG recordings, a deep (DBS) device may be vary its achieve reduction p similar seen medication.
Developments of the past decades have shown it is possible to decode and extract control signals directly from brain for use in neuromotor prosthetics. Currently, there a push towards developing closed loop interface systems. Here we describe our early results rat model sensory/motor neurophysiological feedback system. Traditional operant conditioning techniques historically train an animal increase or decrease occurrence behavior response stimulus using various types reinforcement....