A5089422980- Forensic and Genetic Research
- Genetic diversity and population structure
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Ancient and Medieval Archaeology Studies
- Archaeology and ancient environmental studies
- Forensic Anthropology and Bioarchaeology Studies
- Yersinia bacterium, plague, ectoparasites research
- Estrogen and related hormone effects
- Animal Diversity and Health Studies
- Historical and Archaeological Studies
- Renal and related cancers
- Testicular diseases and treatments
- Eurasian Exchange Networks
- Urinary Tract Infections Management
- Orthopaedic implants and arthroplasty
- Soviet and Russian History
- Bone fractures and treatments
- Vascular Tumors and Angiosarcomas
- Cancer, Stress, Anesthesia, and Immune Response
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Environmental DNA in Biodiversity Studies
- Lung Cancer Treatments and Mutations
- Sympathectomy and Hyperhidrosis Treatments
- Management of metastatic bone disease
University of Szeged
2018-2024
Heinrich Heine University Düsseldorf
1976-1988
Düsseldorf University Hospital
1976-1984
Klinik und Poliklinik für Urologie
1977-1984
University of Münster
1977
Huns, Avars, and conquering Hungarians were migration-period nomadic tribal confederations that arrived in three successive waves the Carpathian Basin between 5th 9th centuries. Based on historical data, each of these groups are thought to have from Asia, although their exact origin relation other ancient modern populations been debated. Recently, hundreds genomes analyzed Central Mongolia, China, which we aimed identify putative source for above-mentioned groups. In this study, sequenced 9...
Abstract Hun, Avar and conquering Hungarian nomadic groups arrived to the Carpathian Basin from Eurasian Steppes significantly influenced its political ethnical landscape, however their origin remains largely unknown. In order shed light on genetic affinity of above we have determined Y chromosomal haplogroups autosomal loci, suitable predict biogeographic ancestry, 49 individuals, supposed represent power/military elit. Haplogroups Hun-age are consistent with Xiongnu ancestry European Huns....
It has been widely accepted that the Finno-Ugric Hungarian language, originated from proto Uralic people, was brought into Carpathian Basin by conquering Hungarians. From middle of 19th century this view prevailed against deep-rooted Hun tradition, maintained in folk memory as well and foreign written medieval sources, which claimed Hungarians were kinsfolk Huns. In order to shed light on genetic origin Conquerors we sequenced 102 mitogenomes early Conqueror cemeteries compared them...
Nomadic groups of conquering Hungarians played a predominant role in Hungarian prehistory, but genetic data are available only from the immigrant elite strata. Most 10–11th century remains Carpathian Basin belong to common people, whose origin and relation have been widely debated. Mitogenome sequences were obtained 202 individuals with next generation sequencing combined hybridization capture. Median joining networks used for phylogenetic analysis. The commoner population was compared 87...
The Hunyadi family is one of the most influential families in history Central Europe 14th–16th centuries. family's prestige was established by Johannes Hunyadi, a Turk-beater who rose to position governor Kingdom Hungary. His second son, Matthias became elected ruler Hungary 1458. had unknown origin. Moreover, failed found dynasty because lacking legitimate heir and his illegitimate son Corvinus unable obtain crown. grandson, Christophorus Corvinus, died childhood, thus direct male line...
Based on the potential progestin sensitivity of growth human renal cell carcinoma, tumour tissue from 88 patients was analysed for receptors. With dextran-coated charcoal assay, cytoplasmic components which bound potent R 5020 specifically and with high affinity could be detected in 42% carcinomas. The apparent dissociation constant R-5020-binder complex amounted to 3.1 ± 1.2 × 10––8 mol/l. Sedimentation sucrose gradients revealed bulk these 4-S region. ligand specificity binding sites...
The Aba family played a pivotal role in Medieval Hungary, dominating vast territories and producing influential figures. We conducted an archaeogenetic study on remains from the necropolis Abasár, political center of clan, to identify members explore their genetic origins. Using Whole Genome Sequencing (WGS) data 19 individuals radiocarbon dating, we identified 6 with close kinship ties. Four males carried identical N1a1a1a1a4∼ haplogroups, our phylogenetic analysis traced this royal...
Summary Huns, Avars and conquering Hungarians were Migration Period nomadic groups which arrived in three successive waves the Carpathian Basin between 5 th 9 centuries. Based on historical data each of these are thought to have from Asia, although their exact origin relation other ancient modern populations has been debated. In this study we sequenced Hun, 143 Avar 113 Hungarian conquest period samples, identified core populations, representing immigrants period, with no recent European...
In order to investigate whether progestins may trigger tumour regression by a mechanism involving the glucocorticoid receptor, human renal cell carcinomas obtained from 15 patients were analysed for cytoplasmic glucocorticoid-binding components, using [3H] dexamethasone. The existence of binders could be demonstrated in 10 out tumours studied. average binding capacity was calculated and found 7.1 fmol/mg cytosol protein. apparent dissociation constant determined cell-free system amounted 1.9...
The Báthory family was one of the most powerful noble families in medieval Hungarian Kingdom. Their influence peaked during Ottoman occupation Hungary, when only partially autonomous region country Transylvania, under Turkish protectorate. Several members became Princes and them, István Báthory, also elected King Poland. We hereby present first genetic data about this extinct family. Archaeological excavations Pericei, a settlement now part Romania, revealed former chapel Through work, two...
Abstract Hun, Avar and conquering Hungarian nomadic groups arrived into the Carpathian Basin from Eurasian Steppes significantly influenced its political ethnical landscape. In order to shed light on genetic affinity of above we have determined Y chromosomal haplogroups autosomal loci, 49 individuals, supposed represent military leaders. Haplogroups Hun-age are consistent with Xiongnu ancestry European Huns. Most Avar-age individuals carry east typical for modern north-eastern Siberian...
Abstract It has been widely accepted that the Finno-Ugric Hungarian language, originated from proto Uralic people, was brought into Carpathian Basin by Conquerors. From middle of 19 th century this view prevailed against deep-rooted Hun tradition, maintained in folk memory as well and foreign written medieval sources, which claimed Hungarians were kinsfolk Huns. In order to shed light on genetic origin Conquerors we sequenced 102 mitogenomes early Conqueror cemeteries compared them sequences...
The binding of methyltrienolone (R 1881, 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-trien-3-one), a highly active synthetic androgen, by cytosol preparations from human renal cell carcinoma was investigated. High-affinity, low-capacity components for R 1881 were detected in 3 out 8 tumours analysed. apparent dissociation constant the 1881-binder complexes found to be range 1.1-2.3 x 10(-9) mol/l. number sites positive varied 2.1 9.7 fmol/mg protein. Studies specificity indicated...
Abstract Background Nomadic groups of conquering Hungarians played a predominant role in Hungarian prehistory, but genetic data are available only from the immigrant elite strata. Most 10-11th century remains Carpathian Basin belong to common people, whose origin and relation has been widely debated. Methods Mitogenome sequences were determined 202 individuals with Next Generation Sequencing combined hybridization capture. Median Joining networks used for phylogenetic analysis. The commoner...
Abstract The Aba family played a pivotal role in the early history of Medieval Hungary dominating extensive territories and giving rise to influential figures. We conducted an archaeogenetic examination remains uncovered at necropolis Abasár, political centre clan, identify members shed light on their genetic origins. Utilizing Whole Genome Sequencing (WGS) data from 19 individuals, complemented by radiocarbon measurements, we identified 6 who shared close kinship relations. Our analysis...
S ummary The nomadic Sarmatians dominated the Pontic Steppe from 3rd century BCE and Great Hungarian Plain 50 CE until Huns’ 4th-century expansion. In this study, we present first large-scale genetic analysis of 156 genomes 1st- to 5th-century Hungary Carpathian foothills. Our findings reveal minor East Asian ancestry in Basin (CB) Sarmatians, distinguishing them other regional populations. Using F4-statistics, qpAdm, IBD analysis, show that CB descended originating Ural Kazakhstan regions,...
Female burials equipped with weapons, a topic of interest among scholars and the general public, remain rare occurrences in archaeological records. The interpretation such cases requires an interdisciplinary approach comprehensive evaluation available evidence, particularly regarding sex potential lifestyle deceased. Consequently, data on specific populations, regions, time periods scarce. For instance, no case has been reported before concerning 10 th century CE Carpathian Basin, known as...
Cytosol preparations obtained from 9 different human renal cell carcinomas were investigated for the eventual presence of progestin-binding inhibitors which might offer an explanation previous failure to demonstrate high receptor levels in tumour tissue. The inhibitory potency these was estimated by measuring decrease R 5020 binding uterine progestin receptors cytosol. Interestingly, cytosol carcinoma found contain inhibitors. average inhibition R-5020-receptor interaction amounted 46%. In...