A5016682260- Protein Structure and Dynamics
- Atmospheric chemistry and aerosols
- Photosynthetic Processes and Mechanisms
- Advancements in Photolithography Techniques
- Porphyrin and Phthalocyanine Chemistry
- Enzyme Structure and Function
- Spectroscopy and Quantum Chemical Studies
- Dental materials and restorations
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Integrated Circuits and Semiconductor Failure Analysis
- Molecular Junctions and Nanostructures
- Hemoglobin structure and function
- Monoclonal and Polyclonal Antibodies Research
- Atmospheric Ozone and Climate
- Electron and X-Ray Spectroscopy Techniques
- Photochemistry and Electron Transfer Studies
- Air Quality Monitoring and Forecasting
- Dental Erosion and Treatment
- Air Quality and Health Impacts
- Asymmetric Hydrogenation and Catalysis
- Carbon Nanotubes in Composites
- Electrochemical Analysis and Applications
- Ionic liquids properties and applications
Carl Zeiss (Germany)
2008-2024
Koblenz University of Applied Sciences
2023
Scripps Research Institute
2010-2022
Scripps (United States)
2021
Scripps Institution of Oceanography
2021
Brandenburg University of Technology Cottbus-Senftenberg
2017
German Meteorological Service
1998-2010
Altonaer Kinderkrankenhaus
2010
University of Iowa
2009
Tulane University
2009
Ultrafast carrier dynamics in individual semiconducting single-walled carbon nanotubes was studied by femtosecond transient absorption and fluorescence measurements. After photoexcitation of the second van Hove singularity a specific tube structure, relaxation electrons holes to fundamental band edge occurs within 100 fs. The decay from this is dependent on excitation density can be rationalized exciton annihilation theory. In contrast fluorescence, has distinctly different time intensity...
The crosslinking reaction of pure poly(acrylic acid) and its blend with poly(vinyl alcohol) was studied by FT-IR spectroscopy. It is demonstrated that also in blends the anhydride formation characteristic for predominant upon heating. But ester between detectable due to C=O vibrations C—O—C vibrations, respectively. degree swelling Young's modulus crosslinked deionized water depend on time temperature heat treatment. In dependence pH-value agent swell or shrink. working energy at shrinking...
A self organizing antimicrobial finish on acrylate-based materials was achieved by adding only 0.4 wt% of a biocidal macromer to the monomer mixture prior polymerization. The surface kills infectious bacterium Staphylococcus aureus without releasing biocide (Figure, lower section) and stays active even after 45 d constant washing. Confocal Raman spectroscopy fluorescence microscopy upper reveal that has migrated during
The evolution of proteins with novel function is thought to start from precursor that are conformationally heterogeneous. corresponding genes may be duplicated and then mutated select optimize a specific conformation. However, testing this idea has been difficult because the challenge quantifying protein flexibility conformational heterogeneity as evolution. Here, we report characterization dynamics for antifluorescein antibody 4-4-20. Using nonlinear laser spectroscopy, surface plasmon...
Abstract Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates, including less‐activated hydrocarbons, transferring peroxide‐borne oxygen. We investigated a cell‐free approach incorporate epoxy and hydroxyl functionalities directly into the bulky molecule testosterone novel unspecific peroxygenase (UPO) that is produced ascomycetous fungus Chaetomium globosum in complex medium rich carbon nitrogen....
Probe probation: The cyano group is sensitive to its environment, absorbs in a unique region of protein IR spectra, and may be appended an amino acid. When investigated variants cytochrome c (see picture: heme-pocket structure) by steady-state time-resolved methods, it was found useful site-specific probe microenvironments dynamics; however, can also perturb environment destabilize the folded state protein. Detailed facts importance specialist readers are published as "Supporting...
Importance: Numerous studies indicate that the traditional categorical classification of severe mental disorders (SMD), such as schizophrenia, bipolar disorders, and major depressive does not align with underlying biology those they frequently overlap in terms symptoms risk factors. Objective: This study aimed to identify transdiagnostic patient clusters based on disease severity explore biological mechanisms independently classification. Design: We utilized data from 443 participants...
SYPRO® Orange (SyO) is a zwitterionic dye that used for protein gel staining, thermal melt assays of proteins, and as marker misfolded proteins. However, while widely utilized, much SyOs’ photophysics remains unexplored. We studied the effect pH on photophysical properties SyO in aqueous solution found two well-defined transitions 0 to 10 range between three species with distinct absorption fluorescence properties. The first transition occurs around 1.5 appears be coupled...
The production of antibodies that selectively bind virtually any foreign compound is the hallmark immune system. While much understood about how sequence diversity contributes to this remarkable feat molecular recognition, little known impacts antibody dynamics, which also expected contribute recognition. Toward goal, we examined a panel elicited chromophoric antigen fluorescein. On basis isothermal titration calorimetry, selected six fluorescein with diverse binding entropies, suggestive...
The alkaline-induced structural transitions of ferricytochrome c have been studied intensively as a model for how changes in metal ligation contribute to protein function and folding. Previous studies demonstrated that multiple non-native species accumulate with increasing pH. Here, we used combination experiments simulations provide high-resolution view the associated alkaline conditions. Alkaline-induced were characterized under equilibrium conditions by following IR absorptions...
Many residues within proteins adopt conformations that appear to be stabilized by interactions between an amide N-H and the N of previous residue. To explore whether these constitute hydrogen bonds, we characterized IR stretching frequencies deuterated variants proline corresponding carbamate, as well four Src homology 3 domain protein. The CδD2 are shifted lower energies due hyperconjugation with Ni electron density, engaging this density via protonation or formation Ni+1-H···Ni interaction...
The aim of this observational retrospective study is to improve early risk stratification hospitalized Covid-19 patients by predicting in-hospital mortality, transfer intensive care unit (ICU) and mechanical ventilation from electronic health record data the first 24 hours after admission. Our machine learning model predicts mortality (AUC = 0.918), ICU 0.821) need for 0.654) a few laboratory Models based on dichotomous features indicating whether value exceeds or falls below threshold...
Abstract Protonation of 1‐alkylimidazoles provides halogen‐free salts which act as ionic liquids and proton reservoir in proton‐ metal‐assisted catalytic processes like dimerisation methyl acrylate ring closing metathesis, lead to significant improvements both activity selectivity.
Octaanionic meso-tetra(3,5-dicarboxylatophenyl) porphyrin 1 was adsorbed to gold electrodes at pH 12 and stayed there after repeated washing with 10-2 M KOH. The fluorescence on sputtered surfaces amounted 10% of the intensity observed an organic subphase. Addition 10-6 aqueous solutions manganese(III) complexes isomer mixture tetracationic β-tetraethyl-β'-tetrakis(1-methyl-4-pyridinium)- meso-4-(1-methyl-4-pyridinium)phenyl porphyrins 2 4 quenched quantitatively. Visible spectroscopy proved...
We describe for the first time an alternative and far more efficient method to synthesise functionalised ionic liquids in a simple, straightforward, two-step synthesis.
Water entrapment occurs at resin-dentin interfaces of one-step self-etch adhesives. We hypothesized that by preventing water fluxes from dentin, any would be attributed to incomplete removal adhesive solvents. tested this hypothesis bonding transparent carious dentin containing occluded dentinal tubules. An experimental single-bottle, was applied flat surfaces caries-affected surrounded sound with or without pulpal pressure. Resin-dentin were examined TEM after silver-impregnation. Although...