A5101713789- Developmental Biology and Gene Regulation
- FOXO transcription factor regulation
- Invertebrate Immune Response Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Neurobiology and Insect Physiology Research
- CRISPR and Genetic Engineering
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Hedgehog Signaling Pathway Studies
- Inflammatory mediators and NSAID effects
- Hippo pathway signaling and YAP/TAZ
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Cells and Metastasis
Institute of Cellular and Organismic Biology, Academia Sinica
2014-2023
Kaohsiung Medical University
2021
Stem cells require different types of supporting cells, or niches, to control stem cell maintenance and differentiation. However, little is known about how those niches are formed. We report that in the development Drosophila melanogaster ovary, Hedgehog (Hh) gradient sets differential affinity for somatic gonadal precursors specify stromal intermingled which contributes both germline differentiation adult. also Traffic Jam (an orthologue a large Maf transcription factor mammals) novel...
Stem cells have an innate ability to occupy their stem cell niche, which in turn, is optimized house cells. Organ aging associated with reduced occupancy the but mechanisms involved are poorly understood. Here, we report that Notch signaling increased age Drosophila female germline (GSCs), and this results removal from niche. Clonal analysis revealed GSCs low levels of exhibit adhesiveness thereby out-competing neighbors higher Notch; altered through regulation E-cadherin expression....
ABSTRACT Diet is an important regulator of stem cell homeostasis; however, the underlying mechanisms this regulation are not fully known. Here, we report that insulin signaling mediates dietary maintenance Drosophila ovarian germline cells (GSCs) by promoting extension niche escort (EC) membranes to wrap around GSCs. This wrapping may facilitate delivery bone morphogenetic protein stemness factors from ECs in In addition effects on GSCs, signaling-mediated EC number and protrusions controls...
Sepsis develops from a serious microbial infection that causes the immune system to go into overdrive. The major microorganisms induce sepsis are Gram-negative bacteria with lipopolysaccharide (LPS) in their cell walls. Nitric oxide (NO) and cyclooxygenase-2 (COX-2) key factors involved LPS-induced pro-inflammatory process. This study aimed evaluate effects of polyphenol Tellimagrandin II (TGII) on anti-inflammatory activity its underlying basic mechanism murine macrophage line RAW 264.7...
Wnt/β-catenin signaling controls various cell fates in metazoan development, and its dysregulation is often associated with cancer formation. However, regulations of this pathway are not completely understood. Here, we report that Lzap, a tumor suppressor, nuclear translocation β-catenin. In zebrafish embryos disruption lzap increases the expression chordin (chd), which encodes bone morphogenetic protein (BMP) antagonist localized prospective dorsal cells promotes fates. Consistently,...
High-sugar diets (HSDs) often lead to obesity and type 2 diabetes, both metabolic syndromes associated with stem cell dysfunction. However, it is unclear whether excess dietary sugar affects cells. Here, we report that HSD impairs function in the intestine ovaries of female Drosophila prior onset insulin resistance, a hallmark diabetes. Although 1 week leads obesity, impaired oogenesis altered lipid metabolism, resistance does not occur. increases glucose uptake by germline cells (GSCs)...