A5072810652- Neuroscience and Neural Engineering
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Corrosion Behavior and Inhibition
- Advanced biosensing and bioanalysis techniques
- Advanced Memory and Neural Computing
- Neuroscience and Neuropharmacology Research
- Electrodeposition and Electroless Coatings
- Neurological disorders and treatments
- Analytical Chemistry and Sensors
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Nanopore and Nanochannel Transport Studies
- Electrostatics and Colloid Interactions
Lawrence Livermore National Laboratory
2016-2024
University of California, Los Angeles
2013-2018
Los Angeles City College
2018
Abstract Environmental stimuli have the ability to generate specific representations of rewards they predict and in so doing alter selection performance reward-seeking actions. The basolateral amygdala participates this process, but precisely how is unknown. To rectify this, we monitored, near-real time, glutamate concentration changes during a test reward-predictive cues influence actions (Pavlovian-instrumental transfer). Glutamate was found be transiently elevated around instrumental...
Electrode arrays for chronic implantation in the brain are a critical technology both neuroscience and medicine. Recently, flexible, thin-film polymer electrode have shown promise facilitating stable, single-unit recordings spanning months rats. While array flexibility enhances integration with neural tissue, it also requires removal of dura mater, tough membrane surrounding brain, temporary bracing to penetrate parenchyma. Durotomy increases swelling, vascular damage, surgical time....
We report a method for electrochemical roughening of thin-film platinum (Pt) electrodes that increases active surface area, decreases electrode impedance, charge injection capacity, sensitivity biosensors and improves adhesion electrochemically deposited films. First, well-established technique thick Pt (wires foils) by oxidation-reduction pulses was modified use on Pt. Optimal with this established protocol in sulfuric acid solution found to occur at about four times lower frequency than...
The brain has the remarkable ability to learn and guide performance of complex tasks. Decades lesion studies suggest that different regions perform specialized functions in support behaviors1-3. Yet recent large-scale neural activity reveal similar patterns encoding distributed widely throughout brain4-6. How these are compatible with regional specialization function remains unclear. Two frontal regions, dorsal medial prefrontal cortex (dmPFC) orbitofrontal (OFC), a paradigm this conundrum....
We present here a microfabricated, multi-functional neural interface with the ability to selectively apply electrical and chemical stimuli, while simultaneously monitoring both activity in brain. Such comprehensive approach is required understand treat neuropsychiatric disorders, such as major depressive disorder (MDD), mechanisms underlying treatments, pharmaceutical therapies deep brain stimulation (DBS). The polymer-based, capable of recording, targeted drug delivery, electrochemical...
A novel means to detect bacteria based on PCR-free, optics-free sensing of 16S RNA at ultralow concentration (<italic>i.e.</italic>, 10<sup>−18</sup>M).
Abstract Electrode arrays for chronic implantation in the brain are a critical technology both neuroscience and medicine. Recently, flexible, thin-film polymer electrode have shown promise facilitating stable, single-unit recordings spanning months rats. While array flexibility enhances integration with neural tissue, it also requires removal of dura mater, tough membrane surrounding brain, temporary bracing to penetrate parenchyma. Durotomy increases swelling, vascular damage, surgical...
The ability to monitor neurotransmitter release in freely behaving animals is key understanding neuronal processes underlying complex behaviors. Commonly used methods either offer rapid measurements of a single analyte (e.g., fast-scan cyclic voltammetry) or provide multiple measurement with insufficient temporal resolution (microdialysis). However, behaviors are controlled by networks employing neurotransmitters and neuromodulators. Efforts understand how neurons within these interact...
This protocol demonstrates a method for electrochemical roughening of thin-film platinum electrodes without preferential dissolution at grain boundaries the metal. Using this method, crack free, macroelectrode surface with up to 40 times increase in active area was obtained. The is easy do standard characterization laboratory and incudes application voltage pulses followed by extended reductive perchloric acid solution. includes chemical preparation both macroscale (1.2 mm diameter)...
This protocol demonstrates a method for electrochemical roughening of thin-film platinum electrodes without preferential dissolution at grain boundaries the metal. Using this method, crack free, macroelectrode surface with up to 40 times increase in active area was obtained. The is easy do standard characterization laboratory and incudes application voltage pulses followed by extended reductive perchloric acid solution. includes chemical preparation both macroscale (1.2 mm diameter)...
Abstract Implantable microelectrode arrays are an effective method for understanding neurotransmitter dynamics with high spatial resolution. In particular, carbon-based electrodes efficient electrochemical detection of dopamine, a studied its role in motor movement and reward-seeking behavior. However, very few options exist arrayed carbon microelectrodes, specifically on flexible polymeric probes. We demonstrate fabrication polyimide probes featuring single walled nanotube (SWCNT)...