A5070627754- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Helminth infection and control
- Cardiac electrophysiology and arrhythmias
- Parasites and Host Interactions
- Heart Rate Variability and Autonomic Control
- Ion channel regulation and function
- Synthesis and Biological Evaluation
University of California, San Diego
2020-2025
Center for Discovery
2021-2025
University Hospital Regensburg
2018
Neglected tropical diseases such as Chagas disease, human African trypanosomiasis, leishmaniasis, and schistosomiasis have a significant global health impact in predominantly developing countries, although these are spreading due to increased international travel population migration. Drug repurposing with focus on increasing antiparasitic potency drug-like properties is cost-effective efficient route the development of new therapies. Here we identify compounds that potent activity against...
AimsEthanol has acute negative inotropic and arrhythmogenic effects. The underlying mechanisms, however, are largely unknown. Sarcoplasmic reticulum Ca2+-leak is an important mechanism for reduced contractility arrhythmias. can be induced by oxidative stress Ca2+/Calmodulin-dependent protein kinase II (CaMKII). Therefore, we investigated the influence of ethanol exposure on excitation-contraction coupling in atrial ventricular cardiomyocytes.Methods resultsIsolated human murine or...
Utilizing a target repurposing and parasite-hopping approach, we tested previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, variety protozoan parasites including cruzi, Leishmania major, donovani, Plasmodium falciparum. This led to the discovery several with submicromolar activities improved physicochemical properties are early leads toward development chemotherapeutic agents kinetoplastid diseases malaria.
Safe and effective treatments for Chagas disease, a potentially fatal parasitic infection associated with cardiac gastrointestinal pathology caused by the kinetoplastid parasite Trypanosoma cruzi, have yet to be developed. Benznidazole nifurtimox, which are currently only available drugs against T. severe adverse effects questionable efficacy in late stage of disease. Natural products proven rich source new chemotypes other infectious agents. We utilized microscopy-based high-throughput...
ABSTRACT Safe and effective treatments for Chagas disease, a potentially fatal parasitic infection associated with cardiac gastrointestinal pathology caused by the kinetoplastid parasite Trypanosoma cruzi , have yet to be developed. Benznidazole nifurtimox, which are currently only available drugs against T. severe adverse effects questionable efficacy in late stage of disease. Natural products proven rich source new chemotypes other infectious agents. We utilized microscopy-based...