A5047812471- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics and Physical Performance
- Sexual Differentiation and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biomedical and Engineering Education
- Cystic Fibrosis Research Advances
- Developmental Biology and Gene Regulation
- Urologic and reproductive health conditions
- Angiogenesis and VEGF in Cancer
- Dietary Effects on Health
- Medical Imaging and Pathology Studies
- Biomarkers in Disease Mechanisms
- Inhalation and Respiratory Drug Delivery
Hadassah Medical Center
2025
Hebrew University of Jerusalem
2021-2022
Aging is an established risk factor for vascular diseases, but aging itself may contribute to the progressive deterioration of organ function. Here, we show in aged mice that endothelial growth (VEGF) signaling insufficiency, which caused by increased production decoy receptors, drive physiological across multiple systems. Increasing VEGF prevented age-associated capillary loss, improved perfusion and function, extended life span. Healthier was evidenced favorable metabolism body composition...
We recently identified a missense mutation in Nucleoporin107 (Nup107; D447N) underlying XX-ovarian-dysgenesis, rare disorder characterized by underdeveloped and dysfunctional ovaries. Modeling of the human Drosophila or specific knockdown Nup107 gonadal soma resulted ovarian-dysgenesis-like phenotypes. Transcriptomic analysis somatic sex-determination gene doublesex (dsx ) as target Nup107. Establishing Dsx primary relevant Nup107, either loss gain is sufficient to mimic rescue phenotypes...
Abstract We recently identified a missense mutation in Nucleoporin107 (Nup107; D447N) underlying XX-ovarian-dysgenesis, rare disorder characterized by underdeveloped and dysfunctional ovaries. Modelling of the human Drosophila or specific knockdown Nup107 gonadal soma resulted ovarian-dysgenesis-like phenotypes. Transcriptomic analysis somatic sex-determination gene doublesex (dsx) as target Nup107. Establishing Dsx primary relevant Nup107, either loss gain is sufficient to mimic rescue...