A5114310310- biodegradable polymer synthesis and properties
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Carbon dioxide utilization in catalysis
- Synthetic Organic Chemistry Methods
- Protein Hydrolysis and Bioactive Peptides
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Low-power high-performance VLSI design
- Protein Structure and Dynamics
- Fullerene Chemistry and Applications
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Embedded Systems Design Techniques
- RNA Research and Splicing
- Chemical Reactions and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Organoselenium and organotellurium chemistry
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Parallel Computing and Optimization Techniques
- Organoboron and organosilicon chemistry
- Probiotics and Fermented Foods
- Organometallic Complex Synthesis and Catalysis
- Advanced Polymer Synthesis and Characterization
Peking University
2018-2025
Beijing National Laboratory for Molecular Sciences
2019-2025
Peking University Cancer Hospital
2025
Peking University People's Hospital
2024
University of Shanghai for Science and Technology
2022-2023
Academy of State Administration of Grain
2022
Ministry of Education
2019
Nankai University
2018
Abstract Background Immunotherapy brings new hope to patients with advanced gastric cancer. However, liver metastases can reduce the efficacy of immunotherapy in patients. Tumor-associated macrophages (TAMs) may be cause this reduction efficacy. SPP1 + TAMs are considered have immunosuppressive properties. We aimed investigate involvement metastasis Methods The single-cell transcriptome was combined batched BULK datasets for analysis. Animal models were used verify analysis results. Results...
The rapid and controlled synthesis of high-molecular-weight (HMW) polysarcosine (pSar), a potential polyethylene glycol (PEG) alternative, via the ring-opening polymerization (ROP) N-carboxyanhydride (NCA) is rare challenging. Here, we report well-controlled ROP sarcosine NCA (Sar-NCA) that catalyzed by various carboxylic acids, which accelerate rate up to 50 times, enables robust pSar with an unprecedented ultrahigh molecular weight (UHMW) 586 kDa (DP ∼ 8200) exceptionally narrow dispersity...
Abstract A great hurdle in the production of synthetic polypeptides lies access N -carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe, and protection side-chain functional groups. Here we report a robust method for preparing unprotected NCA monomers air under moisture. The employs epoxy compounds as ultra-fast scavengers hydrogen chloride to allow assisted ring-closure prevent from acid-catalyzed decomposition moist conditions. broad scope group tolerance...
The ring-opening (co)polymerization (ROP) of N-carboxyanhydride (NCA) monomers bearing unprotected/reactive side groups is rare and challenging. Here, we report the ROP a d-penicillamine NCA (Pen-NCA) monomer for synthesis tertiary thiol-functionalized (co)polypeptides. Through judicious selection reaction solvents use benzoic acid as an additive in ROP, intramolecular isomerization reactions Pen-NCA are suppressed, generating homo- copolypeptides with improved yield, high molecular weight,...
Polythioesters (PTEs) are emerging sustainable polymers for their degradability and recyclability. However, low polymerizability of monomers extensive side reactions often hampered the polymerization process. Moreover, copolymers containing both thioester other types functional groups in backbone highly desirable but rarely accomplished owing to several synthetic challenges. Here, we report ring-opening cascade (ROCAP) N-(2-(acetylthio)ethyl)-glycine N-carboxyanhydrides (TE-NCA) afford...
837 Background: Disitamab vedotin (DV) combined with toripalimab has shown promising efficacy as neoadjuvant therapy for MIBC, a pathological CR (pCR) rate of 62.1% in the previous report (2024 ASCO). In real-world practice, many patients who achieved clinical complete response (cCR) after therapy, confirmed by re-TURBT, imaging, and urine cytology, opted bladder-preserving treatment (BPT). However, biomarkers to confirm absence residual tumors cCR pts are lacking. This study aims evaluate...
We report here the synthesis of water soluble selenopolypeptides via ring-opening polymerization N-carboxyanhydrides. The oligoethylene glycol-bearing are thermally responsive in aqueous solutions with tunable lower critical solution temperatures. polymers can also undergo rapid and reversible helix-coil transitions upon responding to added redox cycle.
The secondary structures of polypeptides, such as an α-helix and a β-sheet, often impart specific properties functions, making the regulation their great significance. Particularly, water-soluble polypeptides bearing β-sheet conformation are rare challenging to achieve. Here, series oligo(ethylene glycol)-modified lysine N-carboxylic anhydrides (EGmK-NCA, where m = 1–3) corresponding polymers EGmKn synthesized, with urethane bonds linker between side-chain EG lysine. structure is delicately...
The rapid and controlled synthesis of high molecular weight (MW) polysarcosine (pSar), a potential polyethylene glycol (PEG) alternative, via the ring-opening polymerization (ROP) N-carboxyanhydride (NCA) is rare challenging. Here, we report carboxylic acid-catalyzed well-controlled ROP Sar-NCA, which accelerates rate up to 50 times, enables robust pSar with unprecedented 586 kDa (DP ~ 8200) exceptionally narrow dispersity (Ð) below 1.02. Density functional theory (DFT) calculations combined...
Abstract Polythioesters (PTEs) are emerging sustainable polymers for their degradability and recyclability. However, low polymerizability of monomers extensive side reactions often hampered the polymerization process. Moreover, copolymers containing both thioester other types functional groups in backbone highly desirable but rarely accomplished owing to several synthetic challenges. Here, we report ring‐opening cascade (ROCAP) N ‐(2‐(acetylthio)ethyl)‐glycine ‐carboxyanhydrides (TE‐NCA)...
An increasing body of evidence indicates that dysregulation liquid-liquid phase separation (LLPS) in cellular processes is implicated the development diverse tumors. Nevertheless, association between LLPS and prognosis, as well tumor immune microenvironment, individuals with colon cancer remains poorly understood.