Glaucoma results from irreversible loss of retinal ganglion cells (RGCs) through an unclear mechanism. Microglial polarization and neuroinflammation play important role in degeneration. Our study aimed to explore the function microglial during glaucoma progression identify a strategy alleviate neuroinflammation. Retinal ischemia/reperfusion injury was induced C57BL/6 mice. In separate cohort animals, interleukin (IL)-4 (50 ng/mL, 2 μL per injection) or vehicle intravitreally injected after...

Abstract Ischaemic preconditioning ( IPC ) attenuates acute kidney injury AKI from renal ischaemia reperfusion. Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against reperfusion injury. Here, it has been suggested that renoprotective effect of is partly mediated renalase. In a model brief intermittent , increased cortex renalase expression was found to last for 48 hrs. significantly reduced tubular inflammation,...

Continuous human motion intent learning may be modeled using a Gaussian process (GP) autoregression based evolving system to cope with the unspecified and time-varying patterns. Electromyography (EMG) signals are primary input. GP is used as mathematical foundation model kinematics by adopting nonlinear autoregressive exogenous inputs (NARX) framework, an applied learn irregular dynamic features. The statistical nature of offers superior flexibility for capable giving credibility prediction,...

Whole-body-based human authentication is a promising approach for remote biometrics scenarios. Current literature focuses on either body recognition based RGB images or gait shapes and walking patterns; both have their advantages drawbacks. In this work, we propose Dual-Modal Ensemble (DME), which combines silhouette data to achieve more robust performances indoor outdoor whole-body recognition. Within DME, GaitPattern, inspired by the double helical pattern used in traditional analysis. The...

Prolonged fasting (PF) was shown to be of great potency promote optimal health and reduce the risk many chronic diseases. This study sought determine effect PF on endothelial progenitor cell (EPC)-mediated angiogenesis in ischemic brain cerebral injury mice.Mice were subjected or periodic after ischemia, histological analysis behavioral tests performed. Mouse EPCs isolated examined, effects EPC transplantation investigated mice.It found that significantly increased functions brain,...

Aims To determine the correspondence between GNAQ R183Q (c.548G＞A) mutation in abnormal scleral tissue of patients with Sturge-Weber syndrome (SWS) secondary glaucoma and explore role pathogenesis. Methods Episcleral tissues were obtained from 8 patients: SWS (n=5) primary congenital (PCG, n=3). Scleral 7 (n=2), PCG (n=1) juvenile open-angle (n=4). was detected by droplet digital PCR. Tissue sections examined immunohistochemistry to expression p-ERK. Results The present 100% sclera. Five...

Glaucoma is one of the major causes ocular morbidity in patients with Sturge-Weber syndrome (SWS). By using multiplex human cytokine antibody array, we simultaneously detected levels 40 cytokines aqueous humor (AH) SWS-induced glaucoma (SG), or from senile cataract as controls. Compared control group, interleukin (IL)-12p40, macrophage inflammatory protein (MIP)-1d, IL-5, IL-7, interleukin-6 receptor (IL-6R), B lymphocyte chemoattractant (BLC), and tumor necrosis factor-alpha (TNF-a) AH were...

Human anatomy is an important medical subject that includes abstract content and strong operability. The lack of specimens required for anatomical experimental teaching unclear observation fine structures lead to difficulties students in learning. As a new technology the field computers, virtual reality (VR) has been widely used great development potential application value. Its use human received increasing attention. This increases sense learning improves effect, including initiative...

A new modular multilevel converter (MMC) sub-module (SM) topology based on the reverse-blocking insulated gate bipolar transistor (RB-IGBT) is proposed in this brief for equipping system with dc fault blocking capability. In addition, has lower conduction loss than all of existing SM topologies side By employing RB-IGBTs circuit, it possible to change current path block without inserting extra semiconductor devices normal path, thus reducing when compared other topologies. comparison between...

Abstract Purpose To explore the relationships between episcleral hemangioma distribution patterns and trabeculotomy prognosis in young Sturge–Weber syndrome (SWS) patients. Methods syndrome‐induced glaucoma patients less than 4 years of age who underwent our Ophthalmology Department from February 2016 to June 2017 were included. Every patient could be divided into simple vascular abnormal network (SEVAN) or multiple (MEVAN) groups according their patterns. The intraocular pressure (IOP) was...

In this paper, a matrix equation for the welding heat source model was proposed to calculate fillet welds temperature distribution based on penetration depth and molten width. A double ellipsoid of weld established firstly by physical experiment simulation calculation, then orthogonal constructed previous calculation methods experimentally measured data. Finally, parameters obtained regression analysis joint The experimental numerical had been performed results show that (1) flux increases...

The installed capacity of renewable energy generation has continued to grow rapidly in recent years along with the global transition towards a 100% renewable-based power system. At same time, grid-connected large-scale brings significant challenges safe and stable operation system due loss synchronous machines. Therefore, self-synchronous wind turbines have attracted wide attention from both academia industry. However, understanding physical mechanisms is not clear. In particular, transient...

Inadequate cytotrophoblast migration and invasion are speculated to result in preeclampsia, which is a pro-inflammatory condition. Sodium dichloroacetate (DCA) exerts anti-inflammatory actions. Thus,we sought investigate the effect of DCA on function lipopolysaccharide (LPS)-stimulated human-trophoblast-derived cell line (HTR-8/SVneo).

The enantioselective mechanism of the Mannich reaction with fluorinated aromatic ketones catalyzed by Zn/prophenol was examined using B3LYP density functional theory.

The Modular Multilevel Converter (MMC) is very suitable for high-power applications like High-Voltage Direct Current (HVDC) transmission system, in which the number of submodules commonly large to reach high voltage. Therefore, sorting algorithm conventional voltage balancing strategy causes too much computational load, greatly increasing hardware cost and challenging controller design. This paper introduces a two-way merge sort that evidently reduces computation weight accelerates sorting,...

Conventional half bridge modular multilevel converter (MMC) system will suffer great over-current when there is a dc side fault. Therefore, topology study in sub-modules with fault blocking capability have become one of the hotspots MMC field. However, topologies using conventional IGBT devices must employ more semiconductors than topology. The extra semiconductor employed lead to increase cost and conduction loss. To reduce loss topology, novel sub-module proposed this paper. employs...

The wireless body area network (WBAN) can monitor human physiological information for a long time and alleviate problems such as the imbalance of medical resources distribution population aging. complex media may make data transmission unstable in networks. A delay-tolerant WBAN opportunity method based on priority was studied. In this method, historical states between links are recorded by sliding window. Then, link stability is measured prediction function. At same time, considering...

A new high performance two-element V2X antenna array is presented, which interspersed between two LTE antennas and designed in shark-fin environment. By using the specific lines closely EM coupling features, desired current distributions element are achieved. Its performance, with 10dB impedance bandwidth of 5% (5.7-6.0GHz), port isolation 23 dB under gain 5.8dBi elevation plane variation less than 5dBi azimuthal plane, finally verified by simulations measurements, showing great potential...

There is a big difference between the life of SiC MOSFET and Si IGBT in inverter based on MOSFET/Si parallel module. The mechanism change trend under different load currents are not clear, which conducive to design optimal rated current ratio In order solve above problems, this paper firstly establishes theoretical model SiC/Si module through analysis. Secondly, simulation built, analyzed by loss-junction temperature analysis method. Finally, results whole life, modified improved.

It is occasionally observed that patients without contrast-induced nephropathy (CIN) develop kidney injury within 1-6 months after coronary angiography (CAG), termed delayed CIN or (DKI) following CAG. The present study aimed to investigate the associated risk factors of and its possible pathogenesis. Subjects with CAG stenting from January 2008 December 2009 were studied. A retrospective survey on DKI was conducted analyzed. There 436 cases receiving complete medical records enrolled in...

Although impedance control has huge application potential in human–robot cooperation, its engineering is still quite limited, owing to the high nonlinearity of dynamics and disturbances. This article presents a novel adaptive neural network controller with extended state observer for interaction using output feedback. The integrates combine their advantages. proposed algorithm can address challenges encountered human–machine systems, example, slow convergence networks, internal external...

Although human–exoskeleton systems have tremendous potentials for rehabilitation training, transparent interaction has not been achieved late-phase rehabilitation. To cope with this challenge, an adaptive pilot intent prediction–based control algorithm is proposed to achieve compliant motion coordination. A novel surface electromyography signal processing method providing definite physical meaning and high computational efficiency derived. The state space model of human musculoskeletal...