Patients with drug-susceptible tuberculosis (TB) show good tolerance of the medications used and have few side effects. However, to treat multidrug-resistant (MDR-TB) many known Here, we studied occurrence effects due treatment patients MDR-TB. We conducted a retrospective consecutive review medical records 256 who received for MDR-TB between January 2006 December 2011. One or more were observed in 95 (37.1%) patients. These led suspension use 1 drugs from regimen individualized prescribed...

Acute renal infarction is often missed or diagnosed late due to its rarity and non-specific clinical manifestations. This study analyzed the laboratory findings of patients with determine whether it affects short- long-term prognosis.We retrospectively reviewed medical records 100 as acute from January 1995 September 2012 at Gyeongsang National University Hospital, Jinju, South Korea.Acute kidney injury (AKI) occurred in 30 patients. Infarct size was positively correlated occurrence AKI (p =...

Intravenous (IV) acyclovir is commonly administered medication for viral infection but well known its nephrotoxicity. However, there was no study incidence, risk factors, and clinical outcomes of acute kidney injury (AKI) associated with IV administration. We retrospectively reviewed the medical records 287 patients who were medicated from January 2008 to May 2013 in Gyeongsang National University Hospital. All had documented histories underwent review. Demographic data, concomitant drugs,...

The use of colistin in the treatment multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated effects aged black garlic extract (ABGE) on colistin-induced kidney injury rats. Rats were assigned four groups. Normal saline was intraperitoneally and intragastrically injected for control group. ABGE Ten mg/kg 6 consecutive days One percent done 30 min prior injection sacrificed next day after last injection. Colistin increased serum levels blood...

Acute kidney injury (AKI) is the most common condition in hospitalized patients. As ischemia/reperfusion-induced AKI (IR-AKI) as a major contributor to end-stage disease, an effective therapeutic intervention for IR-AKI imperative. Erythropoietin (EPO) potent stimulator of erythroid progenitor cells and significantly upregulated during hypoxia. Here, we investigated renoprotective effects EPO mouse model. Mice were assigned sham, only, IR only groups, group was treated with prior injury....

Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence 11%. However, disease mechanism remains unclear, and no effective treatment available. Paricalcitol has been reported to be in animal models injury. We hypothesized that paricalcitol could play a renoprotective role against CI-AKI. Rats were divided into control, paricalcitol, contrast, paricalcitol-plus-contrast groups. used previously published protocol produce...

The appropriate management of vitamin D deficiency and hyperparathyroidism is essential to prevent metabolic bone disorder (MBD) cardiovascular diseases in chronic kidney disease (CKD). Recently, the 24,25-dihydroxyvitamin [24,25(OH)2D] metabolite ratio (VMR), i.e., 24,25(OH)2D 25-hydroxyvitamin [25(OH)D], have emerged as biomarkers level. We analyzed usefulness for evaluation MBD patients with CKD. blood urine samples from 208 outpatients CKD stage G2–G5. 25(OH)D showed a poor correlation...

Background/Objectives: The early detection of individuals at risk cognitive impairment is a clinical imperative. With the recent advancement digital devices, smartphone application-based assessment considered promising tool for screening and monitoring inside outside clinic. This study examined whether smartphone-based assessment, Brain OK, was valid evaluating performance identifying people impairment. Methods: We recruited 88 participants aged over 60. They completed two tests with...

Rationale: Non-autoimmune hypothyroidism is a rare but significant cause of rhabdomyolysis and myocarditis, which can mimic acute coronary syndrome. Early recognition treatment are crucial, especially in patients with chronic kidney disease (CKD), where delayed diagnosis may lead to life-threatening complications such as injury. Patient concerns: A 71-year-old male diabetes, CKD stage G3aA3, history myelogenous leukemia presented myalgia, anorexia, anuria. He also reported intermittent chest...

Renal involvement in scrub typhus ranges from simple urinary abnormalities to acute kidney injury (AKI) leading death. This study evaluated the incidence, predictors and prognosis of AKI associated with according RIFLE (risk, injury, failure, loss, end-stage disease) criteria.

What is known and objective Febuxostat now recommended as the first-line pharmacological urate-lowering therapy for gout in American College of Rheumatology guidelines. There no case rhabdomyolysis associated with febuxostat among reported side effects drug. Our to report on a initiation patient chronic kidney disease (CKD). Case summary A 73-year-old male visited our emergency room due progressive weakness both lower extremities starting 3 days earlier. Ten before presentation, his primary...

Abstract The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) a natural compound antioxidant properties. Studies ALA are performed acute injury tubular apoptosis, inflammation, and oxidative stress. We investigated the effects on EMT-mediated mice unilateral ureteral obstruction (UUO). UUO developed severe...

Ischemia-reperfusion injury (IRI) is a major cause of acute kidney (AKI) and progression to chronic disease (CKD). However, no effective therapeutic intervention has been established for ischemic AKI. Endothelial progenitor cells (EPCs) have roles in the maintenance vascular integrity repair endothelial damage; they also serve as agents various diseases. Thus, we examined whether EPCs renoprotective effect an IRI mouse model. Mice were assigned sham, EPC, IRI-only, EPC-treated groups....

Abstract Background Terlipressin, as a prodrug of vasopressin, has agonistic effects on the V1 receptor and partial renal vasopressin V2 receptors. However, its serum sodium concentration are controversial. Methods This study retrospectively investigated 127 patients with liver cirrhosis to examine incidence risk factors for decrease in level following terlipressin administration. Results Terlipressin was prescribed bleeding control (99) management hepatorenal syndrome (28). Serum decreased...

Although the syndrome of inappropriate antidiuretic hormone has connection with various malignant tumors, there are few reports associated advanced gastric cancer. We describe case a 63-year-old Korean male due to an ectopic hormone-producing adenocarcinoma manifested overt serum hypo-osmolar hyponatremia and high urinary sodium concentrations. His adrenal, thyroidal, renal functioning were normal, improved following removal tumor. The cancer cells immunostained found be positive for...

Bioimpedance analysis (BIA) has been widely used in the evaluation of body composition patients undergoing maintenance hemodialysis. We conducted this study to evaluate impact phase angle (PA) and sarcopenia measured by BIA on clinical prognosis these patients.This longitudinal retrospective enrolled who underwent hemodialysis between January 2016 March 2019. The were stratified into higher (> 4°) lower (≤ 4.0°) PA groups. Sarcopenia was defined when appendicular skeletal muscle mass < 20 kg...

We evaluated whether the neutrophil-to-lymphocyte ratio (NLR) could aid dialysis decision-making in combination with clinical presentation and biochemical findings. retrospectively medical records of 279 patients who commenced chronic maintenance hemodialysis. compared laboratory findings at 6 months before to those initiation. NLR cutoffs risk factors for each six uremic symptoms were determined. Mean age was 60.7 years mean estimated glomerular filtration rate (eGFR) 5.7 ± 2.5 mL/min/1.73...

Rationale: Severe hypokalemia can be a potentially life-threatening disorder and is associated with variable degrees of skeletal muscle weakness. Patient concerns: We report case severe hypokalemic paralysis rhabdomyolysis in 28-year-old bodybuilder. He was admitted to the emergency room due progressive both lower extremities, which had begun 12 hours earlier. bodybuilder trainer participated regional competition 5 days went on binge, consuming large amounts carbohydrates over 4 days,...

Rationale: Only 1 case of IgA nephropathy (IgAN) with minimal change disease (MCD) associated primary Sjögren’s syndrome (SS) has been reported. We additionally describe IgAN MCD SS. Patient concerns: A 80-year-old woman visited our hospital complaining generalized edema that had started 4 weeks prior. She reported a sense thirst and dry eye for the last 5 years. Diagnoses: Her initial laboratory findings were compatible nephrotic syndrome; both antinuclear antibody (1:80) anti-SS-A (Ro)...

A 56-year-old Korean man visited to emergency room due paroxysmal flaccid paralysis in his lower extremities. There was no family or personal history of periodic paralysis. His initial potassium levels were 1.8 mmol/L. The patient had been taking Salicornia herbacea for the treatment diabetes and hypertension. Results a thyroid function test as follows: T3 = 130.40 ng/dL, TSH 0.06 mIU/L, free T4 1.73 ng/dL. scan exhibited decreased uptake (0.6%). symptoms clearly improved serum increased 4.4...

Acute kidney injury (AKI) associated with acute pyelonephritis (APN) rarely has been reported. The aim of this study was to evaluate the incidence and risk factors AKI APN. We retrospectively reviewed medical records 403 patients over 18-year old age hospitalized for APN management from October 2009 September 2014 in tertiary care referral center. Demographic data, clinical symptoms signs, laboratory findings were gathered analyzed. mean 57 years commonly occurred female (87.6%). 253...

We report a case of 66‐year‐old patient with paraquat intoxication resulting in the requirement for hemoperfusion, hemodialysis, and plasma exchange. His initial serum level was 0.24 µg/mL (0.0–0.1 µg/mL). Activated charcoal (50 g) administered orally, high‐dose N‐acetylcysteine (150 mg/kg) intravenously. In addition, immediate 4 h hemoperfusion also performed three consecutive days after admission. Hemodialysis started on 4th day admission because uremia. On 9th admission, laboratory...

The association between acute cholangitis (AC) and kidney injury (AKI) remains unclear. We investigated the incidence, clinical course of AKI in patients with AC, long-term prognosis.We performed a single-center retrospective study hospitalized AC tertiary care center from January 2011 to December 2017. risk factors for were evaluated, severity was analyzed using Systemic Inflammatory Response System (SIRS), quick sequential organ failure assessment (qSOFA) score, 2018 Tokyo Guidelines (TG)...

Abstract Background Page kidney (PK) is the occurrence of hypoperfusion and ischemia due to pressure on by a subcapsular hematoma (SH), mass, or fluid collection. SH after renal transplantation may result in graft loss. Case presentation We present rare case early spontaneous an allograft that led decrease function. A 56-year-old male patient underwent deceased donor transplantation. After declamping, appropriate perfusion immediate diuresis were observed, with no evidence SH. However, his...