A5078947079- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Bacillus and Francisella bacterial research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 detection and testing
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Ion Channels and Receptors
- Clostridium difficile and Clostridium perfringens research
- Biomarkers in Disease Mechanisms
- IL-33, ST2, and ILC Pathways
- Drug-Induced Adverse Reactions
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Immune Response and Inflammation
- Gut microbiota and health
University of Bern
2019-2024
Inserm
2023
Institut Cochin
2023
Université Paris Cité
2023
Federal Department of Home Affairs
2022
Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage modulate inflammation if levels exceed their inhibitors. Here, we show that the intracellular protease inhibitors Serpinb1a Serpinb6a monocyte neutrophil survival in steady-state inflammatory settings by inhibiting cathepsin G (CatG). Importantly, found CatG efficiently cleaved gasdermin D (GSDMD) generate signature N-terminal domain...
Abstract Variant of concern (VOC) Omicron-BA.1 has achieved global predominance in early 2022. Therefore, surveillance and comprehensive characterization advanced primary cell culture systems animal models are urgently needed. Here, we characterize recombinant spike gene mutants comparison with VOC Delta well-differentiated human nasal bronchial epithelial cells vitro, followed by vivo fitness hamsters, ferrets hACE2-expressing mice, immunized hACE2-mice. We demonstrate a spike-mediated...
Abstract Cytosolic proliferating cell nuclear antigen (PCNA) is involved in neutrophil survival and function, which it acts as a scaffold associates with proteins apoptosis, NADPH oxidase activation, cytoskeletal dynamics, metabolism. While the PCNA interactome has been characterized neutrophils under homeostatic conditions, less known about pathophysiological contexts. Granulocyte colony-stimulating factor (G-CSF) cytokine produced response to inflammatory stimuli that regulates many...
SARS-CoV-2 3C-like protease (3CL
Abstract Variant of concern (VOC) Omicron-BA1 has achieved global predominance in early 2022. Therefore, surveillance and comprehensive characterization Omicron-BA.1 advanced primary cell culture systems multiple animal models is urgently needed. Here, we characterized recombinant spike gene mutants comparison with VOC Delta well-differentiated human nasal bronchial epithelial cells vitro, followed by vivo fitness naïve hamsters, ferrets hACE2-expressing mice, immunized hACE2-mice. We...
Mast cells are multifunctional immune scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites contribute to the pathogenesis of allergic reactions. Serine proteases released from secretory granules upon mast cell activation these functions by modulating cytokine activity, platelet proteolytic neutralization toxins. The forced release granule into cytosol induce suicide has recently been proposed as a therapeutic approach reduce...
Invariant natural killer T (iNKT) cells are innate-like lymphocytes. They quickly respond to antigenic stimulation by producing copious amounts of cytokines and chemokines. iNKT precursors differentiate into three subsets iNKT1, iNKT2 iNKT17 with specific cytokine production signatures. While key transcription factors drive subset differentiation, that regulate homeostasis remain incompletely defined. Transcriptomic analyses thymic indicate Serpinb1a is one the most transcripts for...
Cigarette smoke (CS) promotes the development of chronic pulmonary disease and has been associated with increased risk for influenza-related illness. Here, we directly addressed impact CS disordered microbiota on severity influenza A virus (IAV) infection. Specific opportunistic pathogen-free (SOPF) C57BL/6J mice were exposed to or room air (RA) 5.5 months. Each mouse was then cohoused a group recipient germ-free (GF) 1 month microbial transfer. Colonized GF infected intranasally IAV...