A5002846076- Neurobiology and Insect Physiology Research
- Virus-based gene therapy research
- Animal Behavior and Reproduction
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- 14-3-3 protein interactions
- Insect Resistance and Genetics
- Cancer Treatment and Pharmacology
- CRISPR and Genetic Engineering
- Zoonotic diseases and public health
- Microtubule and mitosis dynamics
- Insect and Arachnid Ecology and Behavior
- Silk-based biomaterials and applications
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- interferon and immune responses
- Mosquito-borne diseases and control
- Bat Biology and Ecology Studies
- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
- T-cell and Retrovirus Studies
McMaster University
2023-2025
McMaster University Medical Centre
2024
University of Waterloo
2012-2021
Stanford University
2019
Bats are among the most diverse mammalian species, representing over 20% of diversity. The past two decades have witnessed a disproportionate spillover viruses from bats to humans compared with other hosts, attributed viral richness within bats, their phylogenetic likeness humans, and increased human contact wildlife. Unique evolutionary adaptations in bat genomes, particularly antiviral protection immune tolerance genes, enable serve as reservoirs for pandemic-inducing viruses. Here, we...
Cancer immunotherapy promises to treat challenging cancers including KRAS-mutated colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). However, pre-clinical animal models that better mimic patient tumor immune system interactions are required. While humanized mice promising vehicles for testing, currently used retain limitations, such as lack of a human thymus leukocyte antigen (HLA)-based education T cells. As cytotoxic lymphocyte (CTL) activity underlies many...
Taxanes are a family of natural products with broad spectrum anticancer activity. This activity is mediated by interaction the taxane site beta-tubulin, leading to microtubule stabilization and cell death. Although widely used in treatment breast cancer other malignancies, existing taxane-based therapies including paclitaxel second-generation docetaxel currently limited severe adverse effects dose-limiting toxicity. To discover modulators, we employ computational binding similarity screen >...
Immunogenic cell death (ICD) can switch immunologically "cold" tumors "hot", making them sensitive to immune checkpoint inhibitor (ICI) therapy. Many therapeutic platforms combine multiple modalities such as oncolytic viruses (OVs) and low-dose chemotherapy induce ICD improve prognostic outcomes. We previously detailed many unique properties of bovine herpesvirus type 1 (oBHV) that suggest widespread clinical utility. Here, we show for the first time, ability oBHV monotherapy bona fide...
During Drosophila embryogenesis the majority of extra-embryonic epithelium known as amnioserosa (AS) undergoes programmed cell death (PCD) following completion morphogenetic process dorsal closure. Approximately ten percent AS cells, however, are eliminated during closure by extrusion from epithelium. Using biosensors that report autophagy and caspase activity in vivo, we demonstrate occurs context elevated activation. Furthermore, evaluate rates, autophagy, activation embryos which or...
During Drosophila embryogenesis the process of dorsal closure (DC) results in continuity embryonic epidermis, and DC is well recognized as a model system for analysis epithelial morphogenesis wound healing. flanking lateral epidermal sheets stretch, align, fuse along midline, thereby sealing hole epidermis occupied by an extra-embryonic tissue known amnioserosa (AS). Successful requires regulation cell shape change via actomyosin contractility both AS, this involves bidirectional...
ABSTRACT Steroid hormones influence diverse biological processes throughout the animal life cycle, including metabolism, stress resistance, reproduction, and lifespan. In insects, steroid hormone, 20-hydroxyecdysone (20E), is central hormone regulator of molting metamorphosis, plays roles in tissue morphogenesis. For example, amnioserosa contraction, which a major driving force Drosophila dorsal closure (DC), defective embryos mutant for 20E biosynthesis. Here, we show that signaling...
Apoptosis signal-regulating kinase 1 (ASK1)/MAP3K5 is a stress response that activated by various stimuli. It known as an upstream activator of p38- Mitogen-activated protein (p38MAPK) and c-Jun N-terminal (JNK) are reactive oxygen species (ROS)-induced kinases. Accumulating evidence show ROS accumulate in virus-infected cells. Here, we investigated the relationship between viruses ASK1/p38MAPK or ASK1/JNK pathways. Our findings suggest virus infection activates ASK1 related In parallel,...
Oncolytic viruses are a promising approach for cancer treatment where selectively target and kill cells while also stimulating an immune response. Among with this ability, bovine herpesvirus-1 (BoHV-1) has several advantages, including observations suggesting it may not require viral replication its anti-cancer effects. We previously demonstrated that binding penetration of enveloped virus particles sufficient to trigger intrinsic innate signaling in normal cells, other groups have published...
ABSTRACT Steroid hormones influence diverse biological processes throughout the animal life cycle, including metabolism, stress resistance, reproduction, and lifespan. In insects, steroid hormone, 20-hydroxyecdysone (20E), is central regulator of molting metamorphosis, has been shown to play roles in tissue morphogenesis. For example, amnioserosa contraction, which a major driving force Drosophila dorsal closure (DC), defective embryos mutant for 20E biosynthesis. Here, we show that...