A5082530731- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Chronic Lymphocytic Leukemia Research
- Carbohydrate Chemistry and Synthesis
- Toxin Mechanisms and Immunotoxins
- Ion channel regulation and function
- Pneumocystis jirovecii pneumonia detection and treatment
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Neuroscience of respiration and sleep
- Quinazolinone synthesis and applications
- Monoclonal and Polyclonal Antibodies Research
- Receptor Mechanisms and Signaling
Bangor University
2009-2017
University of Leicester
2016
Mycolic acids (MAs) occur in the cell wall of Mycobacterium tuberculosis as variable mixtures different classes and chain lengths. Here, we address relationship between structure its inflammatory function this virulence factor using single synthetic MA isomers, differing oxygenation class cis- versus α-methyl-trans proximal cyclopropane orientation. Analysis bronchoalveolar inflammation, lung histopathology alveolar macrophage transcription revealed a strong dependence on these meromycolic...
Significance Studies in transfected cells have established that G protein-coupled receptors (GPCRs) activate a number of intracellular signaling pathways; however, which these pathways are physiologically important is unclear. Here, we use genetically engineered mouse to demonstrate novel role for M3-muscarinic acetylcholine receptor (M3-mAChR) phosphorylation airway constriction, with implications human respiratory disease, including asthma and chronic obstructive pulmonary disease....
Cell wall mycolic acids (MA) from Mycobacterium tuberculosis (M.tb) are CD1b presented antigens that can be used to detect antibodies as surrogate markers of active TB, even in HIV coinfected patients. The use the complex mixtures natural MA is complicated by an apparent antibody cross-reactivity with cholesterol. Here firstly we report three recombinant monoclonal scFv fragments chicken germ-line repertoire, which demonstrate possibilities for cross-reactivity: first recognized both...
We report the synthesis of three stereoisomers a mycolic acid from Mycobacterium tuberculosis containing di-cis-cyclopropane and two proximal trans-cyclopropane distal cis-cyclopropane.